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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae P1031
  • locus tag: SPP_2270 [new locus tag: SPP_RS11190 ]
  • pan locus tag?: PNEUPAN003924000
  • symbol: mreC
  • pan gene symbol?: mreC
  • synonym:
  • product: rod shape-determining protein MreC

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPP_2270 [new locus tag: SPP_RS11190 ]
  • symbol: mreC
  • product: rod shape-determining protein MreC
  • replicon: chromosome
  • strand: -
  • coordinates: 2088072..2088890
  • length: 819
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    ATGAACCGTTTTAAAAAATCAAAATATGTCATTATTGTTTTTGTCACTGTTCTGCTTGTG
    TCAGCTCTCTTAGCGACGACTTATTCAAGTACAATTGTGACAAAATTAGGAGATGGAATC
    TCATTGGTTGATAGAGTTGTACAAAAACCTTTTCAGTGGTTTGATTCTGTCAAATCAGAT
    TTGGCTCATTTGACACGAACATATAATGAAAATGAAAGTTTGAAGAAACAGCTTTACCAA
    TTAGAAGTTAAATCAAATGAGGTGGAAAGTTTAAAGACAGAAAATGAACAACTGCGCCAA
    TTGCTTGATATGAAGTCTAAATTGCAAGCCACAAAGACTTTAGCAGCAGATGTTATTATG
    CGTTCTCCGGTATCTTGGAAGCAGGAGTTGACCTTAGATGCAGGTAGATCAAAAGGTGCT
    TCTGAGAACATGTTAGCTATTGCAAATGGTGGCTTGATTGGGAGTGTTTCAAAAGTAGAG
    GAGAACTCTACTATAGTCAACCTTCTGACAAATACGGAAAATGCTGATAAGATTTCTGTT
    AAAATTCAACATGGCTCTACTACAATTTATGGAATTATTATTGGCTATGACAAGGAAAAT
    GACGTTCTTAAAATTAGCCAATTAAATAGTAATAGCGATATTAGTGCGGGAGATAAGGTG
    ACTACTGGTGGATTAGGAAACTTTAACGTTGCTGATATTCCTGTTGGTGAAGTGGTTGCC
    ACAACGCATAGTACAGACTATTTGACACGAGAAGTAACTGTTAAATTGAGTGCAGATACT
    CATAATGTAGATGTGATAGAATTAGTGGGGAATTCATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    819

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPP_2270 [new locus tag: SPP_RS11190 ]
  • symbol: MreC
  • description: rod shape-determining protein MreC
  • length: 272
  • theoretical pI: 6.1475
  • theoretical MW: 29738.6
  • GRAVY: -0.143382

⊟Function[edit | edit source]

  • TIGRFAM:
    Cell structure Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan rod shape-determining protein MreC (TIGR00219; HMM-score: 119.3)
    and 1 more
    Genetic information processing Protein fate Protein and peptide secretion and trafficking preprotein translocase, YajC subunit (TIGR00739; HMM-score: 16.8)
  • TheSEED  :
    • Rod shape-determining protein MreC
    Cell Division and Cell Cycle Cell Division and Cell Cycle - no subcategory Bacterial Cytoskeleton  Rod shape-determining protein MreC
  • PFAM:
    no clan defined MreC; rod shape-determining protein MreC (PF04085; HMM-score: 101.8)
    and 11 more
    YabA; Initiation control protein YabA (PF06156; HMM-score: 17.6)
    PDDEXK (CL0236) Hjc; Archaeal holliday junction resolvase (hjc) (PF01870; HMM-score: 15.7)
    Transthyretin (CL0287) CarboxypepD_reg; Carboxypeptidase regulatory-like domain (PF13620; HMM-score: 15.3)
    no clan defined Geminin; Geminin (PF07412; HMM-score: 15.1)
    DUF2187; Uncharacterized protein conserved in bacteria (DUF2187) (PF09953; HMM-score: 14.2)
    OB (CL0021) RecO_N_2; RecO N terminal (PF13114; HMM-score: 13.6)
    no clan defined TSC22; TSC-22/dip/bun family (PF01166; HMM-score: 11.9)
    Transthyretin (CL0287) CarbopepD_reg_2; CarboxypepD_reg-like domain (PF13715; HMM-score: 11.1)
    no clan defined NYD-SP28_assoc; Sperm tail C-terminal domain (PF14775; HMM-score: 9.8)
    YajC; Preprotein translocase subunit (PF02699; HMM-score: 9)
    HALZ; Homeobox associated leucine zipper (PF02183; HMM-score: 8.6)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: unknown (no significant prediction)
    • Cytoplasmic Score: 2.5
    • Cytoplasmic Membrane Score: 2.5
    • Cellwall Score: 2.5
    • Extracellular Score: 2.5
    • Internal Helix: 1
  • DeepLocPro: Cytoplasmic Membrane
    • Cytoplasmic Score: 0.0005
    • Cytoplasmic Membrane Score: 0.9723
    • Cell wall & surface Score: 0.0021
    • Extracellular Score: 0.025
  • SignalP: Signal peptide SP(Sec/SPI) length 29 aa
    • SP(Sec/SPI): 0.836958
    • TAT(Tat/SPI): 0.001472
    • LIPO(Sec/SPII): 0.070084
    • Cleavage Site: CS pos: 29-30. TYS-ST. Pr: 0.5905
  • predicted transmembrane helices (TMHMM): 1

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: ACO21113 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MNRFKKSKYVIIVFVTVLLVSALLATTYSSTIVTKLGDGISLVDRVVQKPFQWFDSVKSDLAHLTRTYNENESLKKQLYQLEVKSNEVESLKTENEQLRQLLDMKSKLQATKTLAADVIMRSPVSWKQELTLDAGRSKGASENMLAIANGGLIGSVSKVEENSTIVNLLTNTENADKISVKIQHGSTTIYGIIIGYDKENDVLKISQLNSNSDISAGDKVTTGGLGNFNVADIPVGEVVATTHSTDYLTREVTVKLSADTHNVDVIELVGNS

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Adrian D Land, Malcolm E Winkler
The requirement for pneumococcal MreC and MreD is relieved by inactivation of the gene encoding PBP1a.
J Bacteriol: 2011, 193(16);4166-79
[PubMed:21685290] [WorldCat.org] [DOI] (I p)

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