PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 15-OCT-2021

⊟Summary

• organism: Streptococcus pneumoniae P1031
• locus tag: SPP_RS01770 [old locus tag: SPP_0355 ]
• pan locus tag^?: PNEUPAN001112000
• symbol: SPP_RS01770
• pan gene symbol^?: gno
• synonym:
• product: gluconate 5-dehydrogenase

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SPP_RS01770 [old locus tag: SPP_0355 ]
• symbol: SPP_RS01770
• product: gluconate 5-dehydrogenase
• replicon: chromosome
• strand: -
• coordinates: 311110..311925
• length: 816
• essential: unknown

⊟Accession numbers

• Location: NC_012467 (311110..311925) NCBI
• BioCyc: SPP_RS01770 BioCyc
• MicrobesOnline: see SPP_0355
• PneumoBrowse for strain D39V: SPV_0292 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
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  301
  361
  421
  481
  541
  601
  661
  721
  781
  
  ATGACAAATACATCATTCTCAATTGAGCAGTTTTCTTTAAAAGGAAAAATTGCCCTCATC
  ACCGGCGCTTCTTATGGAATTGGATTTGCTATTGCCAAATCCTACGCTGAAGCCGGCGCT
  ACTATTGTCTTTAACGATATCAATCAAGATCTGGTCAATAAAGGGATTAAAGCTTATCGT
  GAAGTTGGCATCGAAGCCCATGGATATGTCTGTGACGTGACAGACGAGGACGGTATCCAA
  GCCATGGTCAAGCAAATCGAACAAGAGATTGGTGTCATTGACATCCTCGTTAATAACGCT
  GGTATTATCCGCCGAGTTCCAATGTGCGAAATGAGCGCCGCTGATTTCCGTAAGGTCATC
  GATATTGACTTAAACGCACCATTTATCGTTTCAAAGGCAGTTATTCCTTCTATGATAAAG
  AAAGGGCATGGAAAGATTATCAATATTTGTTCGATGATGAGCGAACTGGGACGTGAAACA
  GTTAGCGCTTATGCTGCTGCTAAAGGGGGCTTGAAAATGTTGACCCGCAACATTGCGTCT
  GAATACGGTGGAGCCAATATCCAATGTAACGGAATTGGACCGGGTTATATTGCCACTCCT
  CAAACAGCACCTCTTCGTGAGTTGCAAGAAGATGGTTCTCGCCACCCATTTGACCAGTTC
  ATCATTGCAAAAACACCTGCTGCACGTTGGGGAAATCCTGAAGATTTGATGGGCCCTGCT
  GTCTTTCTCGCTAGTGATGCCAGCAATTTTGTCAATGGCCACATCCTATATGTAGATGGC
  GGTATCTTAGCCTACATCGGAAAACAACCTGAGTAA
  60
  120
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  360
  420
  480
  540
  600
  660
  720
  780
  816
  

⊟Protein

⊟General

• locus tag: SPP_RS01770 [old locus tag: SPP_0355 ]
• symbol: SPP_RS01770
• description: gluconate 5-dehydrogenase
• length: 271
• theoretical pI: 5.35811
• theoretical MW: 29061.2
• GRAVY: 0.0749077

⊟Function

• reaction:
  EC 1.1.1.69?  ExPASy
  Gluconate 5-dehydrogenase D-gluconate + NAD(P)⁺ = 5-dehydro-D-gluconate + NAD(P)H
• TIGRFAM:
  Metabolism Energy metabolism Biosynthesis and degradation of polysaccharides 2-deoxy-D-gluconate 3-dehydrogenase (TIGR01832; EC 1.1.1.125; HMM-score: 236.3)
  Metabolism Fatty acid and phospholipid metabolism Biosynthesis 3-oxoacyl-[acyl-carrier-protein] reductase (TIGR01830; EC 1.1.1.100; HMM-score: 215.5)
  3-hydroxybutyrate dehydrogenase (TIGR01963; HMM-score: 191.5)
  and 12 more
  acetoacetyl-CoA reductase (TIGR01829; EC 1.1.1.36; HMM-score: 166.6)
  Unknown function Enzymes of unknown specificity SDR family mycofactocin-dependent oxidoreductase (TIGR03971; EC 1.1.99.-; HMM-score: 164)
  2-hydroxycyclohexanecarboxyl-CoA dehydrogenase (TIGR03206; EC 1.1.1.-; HMM-score: 156.5)
  2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase (TIGR04316; EC 1.3.1.28; HMM-score: 149.5)
  Metabolism Energy metabolism Fermentation acetoin reductases (TIGR02415; EC 1.1.1.-; HMM-score: 148.7)
  Unknown function Enzymes of unknown specificity SDR family mycofactocin-dependent oxidoreductase (TIGR04504; EC 1.1.99.-; HMM-score: 100.4)
  rhamnulose-1-phosphate aldolase/alcohol dehydrogenase (TIGR02632; EC 1.1.1.1,4.1.2.19; HMM-score: 100)
  Metabolism Fatty acid and phospholipid metabolism Biosynthesis putative 3-oxoacyl-(acyl-carrier-protein) reductase (TIGR01831; HMM-score: 86.4)
  cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase (TIGR03325; EC 1.3.1.56; HMM-score: 60.1)
  pteridine reductase (TIGR02685; EC 1.5.1.33; HMM-score: 51.4)
  sepiapterin reductase (TIGR01500; EC 1.1.1.153; HMM-score: 31.5)
  Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Chlorophyll and bacteriochlorphyll light-dependent protochlorophyllide reductase (TIGR01289; EC 1.3.1.33; HMM-score: 23.7)
• TheSEED: see SPP_0355
• PFAM:
  NADP_Rossmann (CL0063) adh_short_C2; Enoyl-(Acyl carrier protein) reductase (PF13561; HMM-score: 214.5)
  adh_short; short chain dehydrogenase (PF00106; HMM-score: 194.6)
  and 3 more
  KR; KR domain (PF08659; HMM-score: 47)
  Epimerase; NAD dependent epimerase/dehydratase family (PF01370; HMM-score: 14.7)
  no clan defined DUF3783; Domain of unknown function (DUF3783) (PF12646; HMM-score: 14.5)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: Cytoplasmic
  • Cytoplasmic Score: 9.97
  • Cytoplasmic Membrane Score: 0
  • Cellwall Score: 0.01
  • Extracellular Score: 0.02
  • Internal Helices: 0
• SignalP: Signal peptide SP(Sec/SPI) length 38 aa
  • SP(Sec/SPI): 0.495586
  • TAT(Tat/SPI): 0.256518
  • LIPO(Sec/SPII): 0.005082
  • Cleavage Site: CS pos: 38-39. AEA-GA. Pr: 0.3757
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: WP_000185883 NCBI
• UniProt:

⊟Protein sequence

• MTNTSFSIEQFSLKGKIALITGASYGIGFAIAKSYAEAGATIVFNDINQDLVNKGIKAYREVGIEAHGYVCDVTDEDGIQAMVKQIEQEIGVIDILVNNAGIIRRVPMCEMSAADFRKVIDIDLNAPFIVSKAVIPSMIKKGHGKIINICSMMSELGRETVSAYAAAKGGLKMLTRNIASEYGGANIQCNGIGPGYIATPQTAPLRELQEDGSRHPFDQFIIAKTPAARWGNPEDLMGPAVFLASDASNFVNGHILYVDGGILAYIGKQPE

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

• MicrobesOnline: SPP_RS01755 < SPP_RS01760 < SPP_RS01765 < SPP_RS01770

⊟Regulation

• regulator: CcpA, RegR* see SPP_0355

⊟Expression data

• PneumoExpress for strain D39V: SPV_0292 PneumoExpress

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications