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serotype 4
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serotype 2
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serotype 19A
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serotype 6B
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serotype 6A
70585
serotype 5
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serotype 23F
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CGSP14
serotype 14
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serotype 19F
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serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 15-OCT-2021

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae P1031
  • locus tag: SPP_RS02245 [old locus tag: SPP_0452 ]
  • pan locus tag?: PNEUPAN001290000
  • symbol: fabG
  • pan gene symbol?: fabG1
  • synonym:
  • product: 3-oxoacyl-[acyl-carrier-protein] reductase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPP_RS02245 [old locus tag: SPP_0452 ]
  • symbol: fabG
  • product: 3-oxoacyl-[acyl-carrier-protein] reductase
  • replicon: chromosome
  • strand: +
  • coordinates: 404829..405560
  • length: 732
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    ATGAAACTAGAACATAAAAATATCTTTATTACAGGTTCGAGTCGTGGAATTGGTCTTGCC
    ATCGCCCACAAGTTTGCTCAAGCAGGAGCCAACATTGTCTTAAACAGTCGTGGGGCAATC
    TCAGAAGAATTGCTCGCTGAGTTTTCAAACTATGGTATCAAGGTGGTTCCCATTTCAGGA
    GATGTATCAGATTTTGCAGACGCTAAGCGTATGATTGATCAAGCTATTGCAGAACTGGGT
    TCAGTAGATGTTTTGGTCAACAATGCAGGGATTACCCAAGATACTCTTATGCTCAAGATG
    ACAGAAGCAGATTTTGAAAAAGTGCTCAAGGTCAATCTGACTGGTGCCTTTAATATGACA
    CAATCAGTCTTGAAACCGATGATGAAAGCCAGAGAAGGTGCTATCATTAATATGTCTAGT
    GTTGTTGGTTTGATGGGGAATATTGGTCAAGCTAACTATGCTGCTTCTAAGGCTGGCTTG
    ATTGGCTTTACCAAGTCTGTGGCACGCGAGGTCGCTAGTCGGAATATACGAGTCAATGTG
    ATTGCTCCAGGAATGATTGAGTCTGATATGACAGCTATCTTATCAGATAAGATTAAGGAA
    GCTACACTAGCTCAGATTCCGATGAAAGAATTTGGGCAGGCAGAGCAGGTTGCAGATTTG
    ACAGTATTTTTAGCAGGCCAAGATTATCTAACTGGTCAAGTGGTTGCCATTGATGGTGGC
    TTAAGTATGTAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    732

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPP_RS02245 [old locus tag: SPP_0452 ]
  • symbol: FabG
  • description: 3-oxoacyl-[acyl-carrier-protein] reductase
  • length: 243
  • theoretical pI: 5.34557
  • theoretical MW: 25755.7
  • GRAVY: 0.239095

⊟Function[edit | edit source]

  • reaction:
    EC 1.1.1.100?  ExPASy
    3-oxoacyl-[acyl-carrier-protein] reductase (3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP+ = 3-oxoacyl-[acyl-carrier-protein] + NADPH
  • TIGRFAM:
    Metabolism Fatty acid and phospholipid metabolism Biosynthesis 3-oxoacyl-[acyl-carrier-protein] reductase (TIGR01830; EC 1.1.1.100; HMM-score: 316.9)
    and 14 more
    acetoacetyl-CoA reductase (TIGR01829; EC 1.1.1.36; HMM-score: 233.5)
    Metabolism Fatty acid and phospholipid metabolism Biosynthesis putative 3-oxoacyl-(acyl-carrier-protein) reductase (TIGR01831; HMM-score: 192.8)
    Metabolism Energy metabolism Biosynthesis and degradation of polysaccharides 2-deoxy-D-gluconate 3-dehydrogenase (TIGR01832; EC 1.1.1.125; HMM-score: 184.8)
    3-hydroxybutyrate dehydrogenase (TIGR01963; HMM-score: 180.1)
    Unknown function Enzymes of unknown specificity SDR family mycofactocin-dependent oxidoreductase (TIGR03971; EC 1.1.99.-; HMM-score: 159.4)
    2-hydroxycyclohexanecarboxyl-CoA dehydrogenase (TIGR03206; EC 1.1.1.-; HMM-score: 150.7)
    Metabolism Energy metabolism Fermentation acetoin reductases (TIGR02415; EC 1.1.1.-; HMM-score: 143.3)
    2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase (TIGR04316; EC 1.3.1.28; HMM-score: 137.3)
    cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase (TIGR03325; EC 1.3.1.56; HMM-score: 104)
    Unknown function Enzymes of unknown specificity SDR family mycofactocin-dependent oxidoreductase (TIGR04504; EC 1.1.99.-; HMM-score: 92.5)
    pteridine reductase (TIGR02685; EC 1.5.1.33; HMM-score: 84.1)
    rhamnulose-1-phosphate aldolase/alcohol dehydrogenase (TIGR02632; EC 1.1.1.1,4.1.2.19; HMM-score: 83)
    sepiapterin reductase (TIGR01500; EC 1.1.1.153; HMM-score: 49.3)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Chlorophyll and bacteriochlorphyll light-dependent protochlorophyllide reductase (TIGR01289; EC 1.3.1.33; HMM-score: 22.2)
  • TheSEED: see SPP_0452
  • PFAM:
    NADP_Rossmann (CL0063) adh_short_C2; Enoyl-(Acyl carrier protein) reductase (PF13561; HMM-score: 210.1)
    adh_short; short chain dehydrogenase (PF00106; HMM-score: 208)
    and 3 more
    KR; KR domain (PF08659; HMM-score: 88.6)
    RmlD_sub_bind; RmlD substrate binding domain (PF04321; HMM-score: 14.3)
    Epimerase; NAD dependent epimerase/dehydratase family (PF01370; HMM-score: 11.7)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.95
    • Cytoplasmic Membrane Score: 0.05
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.108683
    • TAT(Tat/SPI): 0.030341
    • LIPO(Sec/SPII): 0.012004
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000763053 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKLEHKNIFITGSSRGIGLAIAHKFAQAGANIVLNSRGAISEELLAEFSNYGIKVVPISGDVSDFADAKRMIDQAIAELGSVDVLVNNAGITQDTLMLKMTEADFEKVLKVNLTGAFNMTQSVLKPMMKAREGAIINMSSVVGLMGNIGQANYAASKAGLIGFTKSVAREVASRNIRVNVIAPGMIESDMTAILSDKIKEATLAQIPMKEFGQAEQVADLTVFLAGQDYLTGQVVAIDGGLSM

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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