PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 15-OCT-2021

⊟Summary

• organism: Streptococcus pneumoniae P1031
• locus tag: SPP_RS07105 [old locus tag: SPP_1441 ]
• pan locus tag^?: PNEUPAN002749000
• symbol: SPP_RS07105
• pan gene symbol^?: —
• synonym:
• product: helix-turn-helix transcriptional regulator

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SPP_RS07105 [old locus tag: SPP_1441 ]
• symbol: SPP_RS07105
• product: helix-turn-helix transcriptional regulator
• replicon: chromosome
• strand: -
• coordinates: 1346218..1346427
• length: 210
• essential: unknown

⊟Accession numbers

• Location: NC_012467 (1346218..1346427) NCBI
• BioCyc: SPP_RS07105 BioCyc
• MicrobesOnline: see SPP_1441
• PneumoBrowse for strain D39V: SPV_1253 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  
  GTGGCTAAAAATTTAAAATTAAAATTAGCTCGGGTAGAGCGTGATTTAACACAAGGTCAA
  CTGGCAGAGGCTGTCGGGGTGACGCGCCAGACTATTGGTTTGATAGAAGCGGGGAAATAC
  AATCCCAGTCTCTCGCTCTGCCAGTCCATTTGCAGATGTTTAGGGAAAACCCTAGACCAA
  CTATTTTGGGAGGAAGAAGATGAAAAATAG
  60
  120
  180
  210
  

⊟Protein

⊟General

• locus tag: SPP_RS07105 [old locus tag: SPP_1441 ]
• symbol: SPP_RS07105
• description: helix-turn-helix transcriptional regulator
• length: 69
• theoretical pI: 6.49057
• theoretical MW: 7751.93
• GRAVY: -0.330435

⊟Function

• TIGRFAM:
  Signal transduction Regulatory functions DNA interactions transcriptional regulator, y4mF family (TIGR03070; HMM-score: 42.6)
  and 5 more
  putative zinc finger/helix-turn-helix protein, YgiT family (TIGR03830; HMM-score: 14.5)
  probable regulatory domain (TIGR03879; HMM-score: 14.1)
  Genetic information processing Mobile and extrachromosomal element functions Other addiction module antidote protein, HigA family (TIGR02607; HMM-score: 13.7)
  Signal transduction Regulatory functions DNA interactions addiction module antidote protein, HigA family (TIGR02607; HMM-score: 13.7)
  Signal transduction Regulatory functions Protein interactions addiction module antidote protein, HigA family (TIGR02607; HMM-score: 13.7)
• TheSEED: see SPP_1441
• PFAM:
  HTH (CL0123) HTH_3; Helix-turn-helix (PF01381; HMM-score: 57.1)
  and 12 more
  HTH_31; Helix-turn-helix domain (PF13560; HMM-score: 35.7)
  HTH_19; Helix-turn-helix domain (PF12844; HMM-score: 30.5)
  HTH_26; Cro/C1-type HTH DNA-binding domain (PF13443; HMM-score: 19.4)
  HTH_25; Helix-turn-helix domain (PF13413; HMM-score: 17.6)
  HTH_Crp_2; Crp-like helix-turn-helix domain (PF13545; HMM-score: 17.5)
  MarR_2; MarR family (PF12802; HMM-score: 15.6)
  Sigma70_r4; Sigma-70, region 4 (PF04545; HMM-score: 15.4)
  HTH_11; HTH domain (PF08279; HMM-score: 14.6)
  HTH_24; Winged helix-turn-helix DNA-binding (PF13412; HMM-score: 14.5)
  HTH_23; Homeodomain-like domain (PF13384; HMM-score: 14.2)
  YdaS_antitoxin; Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT (PF15943; HMM-score: 13.4)
  HTH_7; Helix-turn-helix domain of resolvase (PF02796; HMM-score: 12.1)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: Cytoplasmic
  • Cytoplasmic Score: 7.5
  • Cytoplasmic Membrane Score: 1.15
  • Cellwall Score: 0.62
  • Extracellular Score: 0.73
  • Internal Helices: 0
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.029112
  • TAT(Tat/SPI): 0.002648
  • LIPO(Sec/SPII): 0.001566
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: WP_001107505 NCBI
• UniProt:

⊟Protein sequence

• MAKNLKLKLARVERDLTQGQLAEAVGVTRQTIGLIEAGKYNPSLSLCQSICRCLGKTLDQLFWEEEDEK

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

• MicrobesOnline: SPP_RS07100 < SPP_RS07105

⊟Regulation

• regulator:

⊟Expression data

• PneumoExpress for strain D39V: SPV_1253 PneumoExpress

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications