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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 22-NOV-2024

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae P1031
  • locus tag: SPP_RS07410 [old locus tag: SPP_1507 ]
  • pan locus tag?: PNEUPAN002769000
  • symbol: tuf
  • pan gene symbol?: tuf
  • synonym:
  • product: elongation factor Tu

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPP_RS07410 [old locus tag: SPP_1507 ]
  • symbol: tuf
  • product: elongation factor Tu
  • replicon: chromosome
  • strand: -
  • coordinates: 1397338..1398534
  • length: 1197
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Location: NC_012467 (1397338..1398534) NCBI
  • BioCyc: SPP_RS07410 BioCyc
  • MicrobesOnline: see SPP_1507
  • PneumoBrowse for strain D39V: SPV_1318 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    ATGGCAAAAGAAAAATACGATCGTAGTAAACCACACGTTAACATTGGTACTATCGGACAC
    GTTGACCACGGTAAAACTACCCTAACTGCAGCTATCACAACTGTTTTGGCACGTCGCTTG
    CCTTCATCAGTTAACCAACCTAAAGACTATGCGTCTATCGATGCTGCTCCAGAAGAACGC
    GAACGCGGTATCACTATCAACACTGCGCACGTTGAGTACGAAACTGAAAAACGTCACTAC
    GCTCACATCGACGCTCCAGGACACGCGGACTACGTTAAAAATATGATCACTGGTGCTGCT
    CAAATGGACGGAGCTATCCTTGTAGTAGCTTCAACTGACGGACCAATGCCACAAACTCGT
    GAGCACATCCTTCTTTCACGTCAGGTTGGTGTTAAACACCTTATCGTCTTCATGAACAAA
    GTTGACTTGGTTGACGACGAAGAATTGCTTGAATTGGTTGAAATGGAAATCCGTGACCTA
    TTGTCAGAATACGACTTCCCAGGTGACGATCTTCCAGTTATCCAAGGTTCAGCACTTAAA
    GCTCTTGAAGGTGACTCTAAATACGAAGACATCGTTATGGAATTGATGAACACAGTTGAT
    GAGTATATCCCAGAACCAGAACGTGACACTGACAAACCATTGCTTCTTCCAGTCGAGGAC
    GTATTCTCAATTACTGGACGTGGTACAGTTGCTTCAGGACGTATCGACCGTGGTATCGTT
    AAAGTCAACGACGAAATCGAAATCGTTGGTATCAAAGAAGAAACTCAAAAAGCAGTTGTT
    ACTGGTGTTGAAATGTTCCGTAAACAACTTGACGAAGGTCTTGCTGGAGATAACGTAGGT
    GTCCTTCTTCGTGGTGTTCAACGTGATGAAATCGAACGTGGACAAGTTATCGCTAAACCA
    GGTTCAATCAACCCACACACTAAATTCAAAGGTGAAGTCTACATCCTTACTAAAGAAGAA
    GGTGGACGTCACACTCCATTCTTCAACAACTACCGTCCACAATTCTACTTCCGTACTACT
    GACGTTACAGGTTCAATCGAACTTCCAGCAGGTACTGAAATGGTAATGCCTGGTGATAAC
    GTGACAATCGACGTTGAGTTGATTCACCCAATCGCCGTAGAACAAGGTACTACATTCTCT
    ATCCGTGAGGGTGGACGTACTGTTGGTTCAGGTATGGTTACAGAAATCGAAGCTTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1197

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPP_RS07410 [old locus tag: SPP_1507 ]
  • symbol: Tuf
  • description: elongation factor Tu
  • length: 398
  • theoretical pI: 4.60517
  • theoretical MW: 43970.4
  • GRAVY: -0.330402

⊟Function[edit | edit source]

  • TIGRFAM:
    Genetic information processing Protein synthesis Translation factors translation elongation factor Tu (TIGR00485; HMM-score: 734.9)
    and 18 more
    Genetic information processing Protein synthesis Translation factors translation elongation factor EF-1, subunit alpha (TIGR00483; HMM-score: 215.2)
    Genetic information processing Protein synthesis Translation factors selenocysteine-specific translation elongation factor (TIGR00475; HMM-score: 187)
    translation initiation factor 2, gamma subunit (TIGR03680; HMM-score: 140.7)
    Cellular processes Cellular processes Adaptations to atypical conditions GTP-binding protein TypA/BipA (TIGR01394; HMM-score: 119.4)
    Genetic information processing Protein synthesis Translation factors GTP-binding protein TypA/BipA (TIGR01394; HMM-score: 119.4)
    Signal transduction Regulatory functions Other GTP-binding protein TypA/BipA (TIGR01394; HMM-score: 119.4)
    Metabolism Central intermediary metabolism Sulfur metabolism sulfate adenylyltransferase, large subunit (TIGR02034; EC 2.7.7.4; HMM-score: 113.7)
    Unknown function General elongation factor 4 (TIGR01393; EC 3.6.5.-; HMM-score: 80.7)
    Genetic information processing Protein synthesis Translation factors translation elongation factor aEF-2 (TIGR00490; HMM-score: 72.6)
    Genetic information processing Protein synthesis Translation factors translation initiation factor IF-2 (TIGR00487; HMM-score: 61.1)
    Genetic information processing Protein synthesis Translation factors translation elongation factor G (TIGR00484; HMM-score: 56.3)
    Unknown function General small GTP-binding protein domain (TIGR00231; HMM-score: 51)
    Genetic information processing Protein synthesis Translation factors peptide chain release factor 3 (TIGR00503; HMM-score: 41.2)
    Genetic information processing Protein synthesis Translation factors translation initiation factor aIF-2 (TIGR00491; HMM-score: 37.6)
    Metabolism Energy metabolism Amino acids and amines ethanolamine utilization protein, EutP (TIGR02528; HMM-score: 15.2)
    Genetic information processing Protein synthesis Other ribosome-associated GTPase EngA (TIGR03594; HMM-score: 14.2)
    Genetic information processing Protein synthesis tRNA and rRNA base modification tRNA modification GTPase TrmE (TIGR00450; EC 3.6.-.-; HMM-score: 11.7)
    Metabolism Energy metabolism Entner-Doudoroff phosphogluconate dehydratase (TIGR01196; EC 4.2.1.12; HMM-score: 11.2)
  • TheSEED: see SPP_1507
  • PFAM:
    P-loop_NTPase (CL0023) GTP_EFTU; Elongation factor Tu GTP binding domain (PF00009; HMM-score: 193.3)
    and 6 more
    no clan defined GTP_EFTU_D3; Elongation factor Tu C-terminal domain (PF03143; HMM-score: 130.1)
    EFTPs (CL0575) GTP_EFTU_D2; Elongation factor Tu domain 2 (PF03144; HMM-score: 59.6)
    P-loop_NTPase (CL0023) MMR_HSR1; 50S ribosome-binding GTPase (PF01926; HMM-score: 20.8)
    RsgA_GTPase; RsgA GTPase (PF03193; HMM-score: 13.9)
    cobW; CobW/HypB/UreG, nucleotide-binding domain (PF02492; HMM-score: 13.5)
    no clan defined GrpE; GrpE (PF01025; HMM-score: 12.4)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 10
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9946
    • Cytoplasmic Membrane Score: 0.0012
    • Cell wall & surface Score: 0
    • Extracellular Score: 0.0042
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.017506
    • TAT(Tat/SPI): 0.004069
    • LIPO(Sec/SPII): 0.003221
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MAKEKYDRSKPHVNIGTIGHVDHGKTTLTAAITTVLARRLPSSVNQPKDYASIDAAPEERERGITINTAHVEYETEKRHYAHIDAPGHADYVKNMITGAAQMDGAILVVASTDGPMPQTREHILLSRQVGVKHLIVFMNKVDLVDDEELLELVEMEIRDLLSEYDFPGDDLPVIQGSALKALEGDSKYEDIVMELMNTVDEYIPEPERDTDKPLLLPVEDVFSITGRGTVASGRIDRGIVKVNDEIEIVGIKEETQKAVVTGVEMFRKQLDEGLAGDNVGVLLRGVQRDEIERGQVIAKPGSINPHTKFKGEVYILTKEEGGRHTPFFNNYRPQFYFRTTDVTGSIELPAGTEMVMPGDNVTIDVELIHPIAVEQGTTFSIREGGRTVGSGMVTEIEA

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Sarbani Mohan, Christian Hertweck, Antje Dudda, Sven Hammerschmidt, Christine Skerka, Teresia Hallström, Peter F Zipfel
Tuf of Streptococcus pneumoniae is a surface displayed human complement regulator binding protein.
Mol Immunol: 2014, 62(1);249-64
[PubMed:25046156] [WorldCat.org] [DOI] (I p)

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