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serotype 1

NCBI: 26-OCT-2021

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae R6
  • locus tag: SPR_RS03995 [old locus tag: spr0796 ]
  • pan locus tag?: PNEUPAN001892000
  • symbol: pfkA
  • pan gene symbol?: pfkA
  • synonym:
  • product: 6-phosphofructokinase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPR_RS03995 [old locus tag: spr0796 ]
  • symbol: pfkA
  • product: 6-phosphofructokinase
  • replicon: chromosome
  • strand: +
  • coordinates: 799177..800184
  • length: 1008
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    ATGAAACGTATTGCTGTTTTGACTAGTGGCGGAGACGCACCTGGTATGAACGCTGCCATC
    CGTGCAGTTGTTCGTCAAGCAATTTCAGAAGGAATGGAAGTGTTTGGTATCTATGACGGA
    TATGCTGGTATGGTTGCCGGTGAAATTCATCCCCTAGATGCAGCTTCAGTAGGGGACATC
    ATTTCTCGTGGTGGTACTTTTCTTCACTCAGCTCGTTATCCAGAGTTCGCTCAACTTGAA
    GGGCAACTTAAAGGGATTGAGCAATTGAAAAAACACGGAATTGAAGGTGTAGTTGTTATC
    GGTGGTGACGGATCTTACCACGGCGCTATGCGTTTGACTGAACATGGCTTCCCAGCTATT
    GGTCTTCCAGGTACAATCGATAACGATATCGTTGGTACTGACTTTACAATCGGTTTTGAC
    ACAGCGGTTACTACTGCCATGGACGCTATCGATAAGATTCGTGATACATCATCAAGTCAC
    CGTCGTACTTTTGTAATCGAAGTTATGGGACGTAACGCTGGTGATATCGCTCTTTGGGCT
    GGTATTGCAACTGGTGCTGATGAAATCATCATCCCTGAAGCAGGCTTCAAGATGGAAGAT
    ATCGTAGCAAGCATCAAAGCTGGTTATGAATGTGGTAAAAAACACAATATCATCGTCTTA
    GCTGAAGGTGTGATGTCAGCGGCTGAATTTGGTCAAAAACTTAAAGAAGCTGGAGATATA
    AGCGACCTTCGTGTAACAGAACTTGGACATATTCAACGTGGTGGTTCTCCAACTCCGCGT
    GACCGTGTTTTGGCGTCACGTATGGGTGCACATGCTGTTAAACTTCTTAAAGAAGGTATC
    GGTGGTGTTGCGGTTGGTATTCGTAACGAAAAAATGGTTGAAAATCCAATTCTTGGTACT
    GCAGAAGAAGGGGCATTGTTTAGCCTTACTGCAGAAGGTAAGATTGTGGTTAACAACCCA
    CACGAAGCCGATATTGAGCTATCTAGCTTGAATAAGAGCTTGTCATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1008

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPR_RS03995 [old locus tag: spr0796 ]
  • symbol: PfkA
  • description: 6-phosphofructokinase
  • length: 335
  • theoretical pI: 5.24291
  • theoretical MW: 35212.9
  • GRAVY: 0.0304478

⊟Function[edit | edit source]

  • ⊞reaction:
    EC 2.7.1.11?  ExPASy
    6-phosphofructokinase ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate
  • ⊞TIGRFAM:
    Metabolism Energy metabolism Glycolysis/gluconeogenesis 6-phosphofructokinase (TIGR02482; EC 2.7.1.11; HMM-score: 412.6)
    and 3 more
    Metabolism Energy metabolism Glycolysis/gluconeogenesis phosphofructokinase (TIGR02483; HMM-score: 307.5)
    6-phosphofructokinase (TIGR02478; EC 2.7.1.11; HMM-score: 270.9)
    Metabolism Energy metabolism Glycolysis/gluconeogenesis diphosphate--fructose-6-phosphate 1-phosphotransferase (TIGR02477; EC 2.7.1.90; HMM-score: 73.4)
  • TheSEED: see spr0796
  • ⊞PFAM:
    PFK (CL0240) PFK; Phosphofructokinase (PF00365; HMM-score: 354.7)
    and 2 more
    NAD_kinase; ATP-NAD kinase N-terminal domain (PF01513; HMM-score: 16.4)
    Periplas_BP (CL0144) Peripla_BP_1; Periplasmic binding proteins and sugar binding domain of LacI family (PF00532; HMM-score: 12.4)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • ⊞PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • ⊞SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.020315
    • TAT(Tat/SPI): 0.000856
    • LIPO(Sec/SPII): 0.001981
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MKRIAVLTSGGDAPGMNAAIRAVVRQAISEGMEVFGIYDGYAGMVAGEIHPLDAASVGDIISRGGTFLHSARYPEFAQLEGQLKGIEQLKKHGIEGVVVIGGDGSYHGAMRLTEHGFPAIGLPGTIDNDIVGTDFTIGFDTAVTTAMDAIDKIRDTSSSHRRTFVIEVMGRNAGDIALWAGIATGADEIIIPEAGFKMEDIVASIKAGYECGKKHNIIVLAEGVMSAAEFGQKLKEAGDISDLRVTELGHIQRGGSPTPRDRVLASRMGAHAVKLLKEGIGGVAVGIRNEKMVENPILGTAEEGALFSLTAEGKIVVNNPHEADIELSSLNKSLS

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊞Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊞Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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