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PangenomeTIGR4
serotype 4
D39serotype 2
D39Vserotype 2
Hungary19A-6serotype 19A
EF3030serotype 19F
670-6Bserotype 6B
6A-10serotype 6A
70585serotype 5
A026serotype 19F
A66serotype 3
AP200serotype 11A
ASP0581serotype 12F
ATCC 49619serotype 19F
ATCC 700669serotype 23F
BM6001serotype 19F
BVJ1JLserotype 1
CGSP14serotype 14
G54serotype 19F
HU-OHserotype 3
Hu15serotype 19A
Hu17serotype 19A
INV104serotype 1
INV200serotype 14
JJAserotype 14
MDRSPN001serotype 19F
NCTC7465serotype 1
NCTC7466serotype 2
NU83127serotype 4
OXC141serotype 3
P1031serotype 1
R6serotype 2
SP49serotype 19A
SPN032672serotype 1
SPN034156serotype 3
SPN034183serotype 3
SPN994038serotype 3
SPN994039serotype 3
SPNA45serotype 3
ST556serotype 19F
TCH8431/19Aserotype 19A
Taiwan19F-14serotype 19F
Xen35serotype 4
gamPNI0373serotype 1
NCBI: 25-NOV-2024
⊟Summary[edit | edit source]
- organism: Streptococcus pneumoniae R6
- locus tag: SPR_RS04235 [old locus tag: spr0845 ]
- pan locus tag?: PNEUPAN001932000
- symbol: pyrH
- pan gene symbol?: pyrH
- synonym:
- product: UMP kinase
⊟Genome View[edit | edit source]
⊟Gene[edit | edit source]
⊟General[edit | edit source]
⊟Accession numbers[edit | edit source]
- Location: NC_003098 (843223..843960) NCBI
- BioCyc: see spr0845
- MicrobesOnline: see spr0845
- PneumoBrowse for strain D39V: SPV_0834 PneumoBrowse
⊟Phenotype[edit | edit source]
Share your knowledge and add information here. [edit]
⊟DNA sequence[edit | edit source]
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721ATGGCGAATCCCAAGTATAAACGTATTTTAATCAAGTTATCAGGTGAAGCCCTTGCCGGT
GAACGTGGCGTAGGGATTGATATCCAAACAGTTCAAACAATCGCAAAAGAGATTCAAGAA
GTTCATAGCTTAGGTATCGAAATTGCCCTTGTTATTGGTGGAGGAAATCTTTGGCGTGGA
GAACCTGCAGCAGAAGCAGGTATGGACCGTGTTCAGGCAGATTACACTGGAATGCTTGGG
ACTGTTATGAATGCTCTTGTGATGGCAGATTCATTGCAACAAGTTGGGGTTGATACGCGT
GTACAAACAGCTATTGCTATGCAACAAGTGGCAGAGCCTTATGTCCGTGGACGTGCCCTT
CGTCACCTTGAAAAAGGCCGTATCGTTATCTTTGGTGCTGGAATTGGTTCACCATACTTC
TCGACAGATACAACAGCGGCCCTTCGTGCAGCTGAAATCGAAGCAGATGCCATCCTCATG
GCTAAAAATGGCGTCGATGGTGTGTACAATGCCGATCCTAAGAAGGACAAGACAGCCGTT
AAGTTTGAAGAATTGACCCACCGTGATGTTATCAACAAAGGTCTTCGTATCATGGACTCA
ACAGCCTCAACCCTCTCAATGGACAACGACATTGACTTGGTTGTCTTCAACATGAACCAA
TCAGGCAACATCAAACGTGTCGTATTTGGTGAAAATATCGGAACAACAGTTTCAAATAAT
ATCGAAGAAAAGGAATAA60
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⊟Protein[edit | edit source]
⊟General[edit | edit source]
- locus tag: SPR_RS04235 [old locus tag: spr0845 ]
- symbol: PyrH
- description: UMP kinase
- length: 245
- theoretical pI: 4.99248
- theoretical MW: 26433
- GRAVY: -0.0959184
⊟Function[edit | edit source]
- reaction: EC 2.7.4.22? ExPASyUMP kinase ATP + UMP = ADP + UDP
- TIGRFAM: Purines, pyrimidines, nucleosides, and nucleotides Nucleotide and nucleoside interconversions UMP kinase (TIGR02075; EC 2.7.4.22; HMM-score: 322.6)and 4 morePurines, pyrimidines, nucleosides, and nucleotides Nucleotide and nucleoside interconversions putative uridylate kinase (TIGR02076; EC 2.7.4.-; HMM-score: 91.9)Amino acid biosynthesis Aspartate family aspartate kinase, monofunctional class (TIGR00656; EC 2.7.2.4; HMM-score: 29.6)Amino acid biosynthesis Glutamate family glutamate 5-kinase (TIGR01027; EC 2.7.2.11; HMM-score: 28.7)Amino acid biosynthesis Aspartate family aspartate kinase (TIGR00657; EC 2.7.2.4; HMM-score: 28.2)
- TheSEED: see spr0845
- PFAM: no clan defined AA_kinase; Amino acid kinase family (PF00696; HMM-score: 95.8)
⊟Structure, modifications & cofactors[edit | edit source]
- domains:
- modifications:
- cofactors:
- effectors:
⊟Localization[edit | edit source]
- PSORTb: Cytoplasmic
- Cytoplasmic Score: 7.5
- Cytoplasmic Membrane Score: 1.15
- Cellwall Score: 0.62
- Extracellular Score: 0.73
- Internal Helices: 0
- DeepLocPro: Cytoplasmic
- Cytoplasmic Score: 0.9516
- Cytoplasmic Membrane Score: 0.0215
- Cell wall & surface Score: 0.0001
- Extracellular Score: 0.0268
- SignalP: no predicted signal peptide
- SP(Sec/SPI): 0.003882
- TAT(Tat/SPI): 0.000256
- LIPO(Sec/SPII): 0.000439
- predicted transmembrane helices (TMHMM): 0
⊟Accession numbers[edit | edit source]
⊟Protein sequence[edit | edit source]
- MANPKYKRILIKLSGEALAGERGVGIDIQTVQTIAKEIQEVHSLGIEIALVIGGGNLWRGEPAAEAGMDRVQADYTGMLGTVMNALVMADSLQQVGVDTRVQTAIAMQQVAEPYVRGRALRHLEKGRIVIFGAGIGSPYFSTDTTAALRAAEIEADAILMAKNGVDGVYNADPKKDKTAVKFEELTHRDVINKGLRIMDSTASTLSMDNDIDLVVFNMNQSGNIKRVVFGENIGTTVSNNIEEKE
⊟Experimental data[edit | edit source]
- protein localization:
- interaction partners:
⊟Expression & Regulation[edit | edit source]
⊟Operon[edit | edit source]
- MicrobesOnline: pyrH > frr > cvfB > SPR_RS04250
⊟Regulation[edit | edit source]
- regulator:
⊟Transcription[edit | edit source]
- transcription start site:
⊟Expression data[edit | edit source]
- PneumoExpress for strain D39V: SPV_0834 PneumoExpress
⊟Biological Material[edit | edit source]
⊟Mutants[edit | edit source]
⊟Expression vector[edit | edit source]
⊟lacZ fusion[edit | edit source]
⊟GFP fusion[edit | edit source]
⊟two-hybrid system[edit | edit source]
⊟FLAG-tag construct[edit | edit source]
⊟Antibody[edit | edit source]
⊟Other Information[edit | edit source]
You can add further information about the gene and protein here. [edit]
⊟Literature[edit | edit source]
⊟References[edit | edit source]
- ↑ Jane A Thanassi, Sandra L Hartman-Neumann, Thomas J Dougherty, Brian A Dougherty, Michael J Pucci
Identification of 113 conserved essential genes using a high-throughput gene disruption system in Streptococcus pneumoniae.
Nucleic Acids Res: 2002, 30(14);3152-62
[PubMed:12136097] [WorldCat.org] [DOI] (I p)