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JJA
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MDRSPN001
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NCTC7466
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serotype 4
OXC141
serotype 3
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serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
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SPN994038
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TCH8431/19A
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serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 26-OCT-2021

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae R6
  • locus tag: SPR_RS04525 [old locus tag: spr0905 ]
  • pan locus tag?: PNEUPAN002029000
  • symbol: SPR_RS04525
  • pan gene symbol?: yfnA
  • synonym:
  • product: amino acid permease

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPR_RS04525 [old locus tag: spr0905 ]
  • symbol: SPR_RS04525
  • product: amino acid permease
  • replicon: chromosome
  • strand: +
  • coordinates: 889910..891301
  • length: 1392
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    ATGAATATATTTAGAACAAAGAATGTTAGTTTAGATAAAACAGAGATGCATAGGCATTTG
    AAGTTATGGGATTTGATTTTGCTGGGTATTGGAGCCATGGTAGGGACAGGTGTTTTTACA
    ATCACAGGTACTGCAGCTGCTACACTTGCTGGTCCAGCACTAGTGATTTCAATCGTTATT
    TCTGCCTTGTGTGTGGGATTATCAGCCCTCTTTTTTGCAGAATTTGCCTCGCGAGTACCC
    GCTACAGGAGGTGCCTATAGTTACCTCTATGCTATCTTAGGAGAATTCCCTGCCTGGTTG
    GCTGGTTGGTTAACCATGATGGAGTTCATGACAGCCATATCAGGCGTAGCTTCGGGTTGG
    GCAGCTTATTTTAAAGGCTTGCTCTCTCAATACGGGATAGCCCTTCCTCAGGCTTTAAAT
    GGTACCTTTAATCCTCAAGCAGGGACATTTGTTGATTTATTGCCTATTCTTGTCTTGGTC
    TTGGTGACTTCGCTTGTTTTACTAAATGCCAAGGCAGCCTTACGCTTTAATTCGATTCTA
    GTTATTTTGAAATTTTCCGCTTTAGCTCTCTTTGTTTTAGTAGGAATTTGGAATATTAAG
    TTTGATAATTGGAGCAATTTTGCTCCTTACGGTTTTGGACAAATCTATGGAGCTAGTACT
    GGTATTATGGCTGGTGCGTCCTTGATGTTCTTCGGTTTTTTGGGATTTGAATCCATCTCT
    ATGGCTGTAGATGAAGTCAAGACTCCTCAAAAAAATATTCCTAGAGGGATTGTCTTATCG
    CTTTCTATCGTAACCATTCTCTATGCCTTGGTGACCCTTGTTTTGACTGGTGTGGTTCAC
    TATAGTCATTTAAATGTCGATGATGCCGTTGCCTTTGCCCTTCGTAGTGTTGGGATTAGT
    TGGGCAGCCAACTATGTGTCATTAGTGGCTATCTTGACCTTGATTACAGTTTGTATTTCG
    ATGACCTATGCCCTATCGCGTATGATTTACAGTTTAGCACGTGACGGCTTAGTGCCTGCT
    GCCTTTAAGGAACTGACGAAGACTAGCAAGGTACCAAAGAATGCTACTATCTTGACAGGT
    CTAGCTTCAGCAGTAGCAGCAGGAATGTTCCCACTAGCCAGTATTGCAGCCTTTTTAAAT
    ATTTGTACCTTAGCCTACTTGATCCTGCTGGCTTATGGTCTGATTCGCTTACGGAAAGAA
    AAAGGAATGCCCAAAGCTGGGGAATTTAAAACACCATTGGTACCTCTGTTACCAATTTTA
    TCGATCATCATTTGTTTATCCTTCATGTTACAGTATAATGTGAACACCTGGATTGCTTTC
    CTAGTTGCGTTGTTAGTAGGAAGTATTATTTACTTCACTTATGGCTATAAGCATTCTACC
    ATAGAAGAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1392

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPR_RS04525 [old locus tag: spr0905 ]
  • symbol: SPR_RS04525
  • description: amino acid permease
  • length: 463
  • theoretical pI: 9.49976
  • theoretical MW: 49802
  • GRAVY: 0.908639

⊟Function[edit | edit source]

  • TIGRFAM:
    Metabolism Transport and binding proteins Amino acids, peptides and amines amino acid transporter (TIGR00909; HMM-score: 339.9)
    Metabolism Transport and binding proteins Amino acids, peptides and amines cationic amino acid transport permease (TIGR00906; HMM-score: 289.4)
    and 11 more
    Metabolism Transport and binding proteins Amino acids, peptides and amines L-type amino acid transporter (TIGR00911; HMM-score: 103.6)
    Metabolism Transport and binding proteins Amino acids, peptides and amines transporter, basic amino acid/polyamine antiporter (APA) family (TIGR00905; HMM-score: 83.6)
    Metabolism Transport and binding proteins Amino acids, peptides and amines ethanolamine permease (TIGR00908; HMM-score: 79.2)
    Metabolism Transport and binding proteins Amino acids, peptides and amines GABA permease (TIGR01773; HMM-score: 64.6)
    Metabolism Transport and binding proteins Amino acids, peptides and amines arginine-ornithine antiporter (TIGR03810; HMM-score: 64)
    Metabolism Transport and binding proteins Amino acids, peptides and amines amino acid permease (yeast) (TIGR00913; HMM-score: 61.1)
    Metabolism Transport and binding proteins Amino acids, peptides and amines amino acid permease (TIGR00907; HMM-score: 58.4)
    permease, urea carboxylase system (TIGR03428; HMM-score: 51.9)
    histidine-histamine antiporter (TIGR04298; HMM-score: 36.6)
    Metabolism Transport and binding proteins Amino acids, peptides and amines aromatic amino acid transport protein (TIGR00837; HMM-score: 24.5)
    putrescine-ornithine antiporter (TIGR04299; HMM-score: 10.7)
  • TheSEED: see spr0905
  • PFAM:
    APC (CL0062) AA_permease_2; Amino acid permease (PF13520; HMM-score: 156.9)
    AA_permease; Amino acid permease (PF00324; HMM-score: 143.8)
    and 2 more
    AA_permease_C; C-terminus of AA_permease (PF13906; HMM-score: 49.8)
    VSA (CL0656) Stevor; Subtelomeric Variable Open Reading frame (PF17410; HMM-score: 7.4)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 12
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.046924
    • TAT(Tat/SPI): 0.006434
    • LIPO(Sec/SPII): 0.013921
  • predicted transmembrane helices (TMHMM): 11

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MNIFRTKNVSLDKTEMHRHLKLWDLILLGIGAMVGTGVFTITGTAAATLAGPALVISIVISALCVGLSALFFAEFASRVPATGGAYSYLYAILGEFPAWLAGWLTMMEFMTAISGVASGWAAYFKGLLSQYGIALPQALNGTFNPQAGTFVDLLPILVLVLVTSLVLLNAKAALRFNSILVILKFSALALFVLVGIWNIKFDNWSNFAPYGFGQIYGASTGIMAGASLMFFGFLGFESISMAVDEVKTPQKNIPRGIVLSLSIVTILYALVTLVLTGVVHYSHLNVDDAVAFALRSVGISWAANYVSLVAILTLITVCISMTYALSRMIYSLARDGLVPAAFKELTKTSKVPKNATILTGLASAVAAGMFPLASIAAFLNICTLAYLILLAYGLIRLRKEKGMPKAGEFKTPLVPLLPILSIIICLSFMLQYNVNTWIAFLVALLVGSIIYFTYGYKHSTIEE

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator: AhrC, ArgR1* see spr0905

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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