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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 25-NOV-2024

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae R6
  • locus tag: SPR_RS07005 [old locus tag: spr1410 ]
  • pan locus tag?: PNEUPAN002838000
  • symbol: SPR_RS07005
  • pan gene symbol?: pacL
  • synonym:
  • product: cation-translocating P-type ATPase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPR_RS07005 [old locus tag: spr1410 ]
  • symbol: SPR_RS07005
  • product: cation-translocating P-type ATPase
  • replicon: chromosome
  • strand: -
  • coordinates: 1393746..1396442
  • length: 2697
  • essential: yes [1] DEG other strains

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    2101
    2161
    2221
    2281
    2341
    2401
    2461
    2521
    2581
    2641
    ATGTCAAAAGAACAAAAACGCCAAGCGTTTTATACTCAGAGCCCTGAAGAGGTCTTGCAG
    GCTGTGGATGCGACCGAGCAAGGTTTGTCATCAAGTGAGGCGGAAAAGCGCCTTGCCGAA
    TTTGGGCACAATGAACTCGAAGAAGGCGAGAAACGATCAATCTTGGTCAAATTCATCGAG
    CAATTTAAGGATTTGATGATTATCATCCTAGTTGCGGCAGCAATCTTGTCAGTCGTGACT
    TCTGGTGGGGAAGATATCGCAGATGCCATTATCATCCTAGCTGTGGTTATCATCAACGCT
    GCCTTTGGTGTTTACCAAGAAGGAAAAGCTGAAGAAGCTATTGAAGCCCTCAAATCCATG
    TCTAGTCCAGTTGCCCGCGTTCTTCGTGATGGACACATGGCAGAGATTGACTCTAAAGAA
    TTGGTACCAGGCGATATCGTTGCCCTTGAAGCAGGTGACGTGGTACCAGCGGACCTACGT
    TTGATAGAAGCCAACTCTCTTAAAATTGAAGAAGCAGCCTTGACAGGTGAATCTGTACCA
    GTCGAAAAAGACTTGTCAGTCGATCTTGCGACAGATGCTGGCATTGGTGACCGTGTCAAC
    ATGGCCTTCCAAAACTCAAACGTAACCTATGGTCGTGGGATGGGTGTTGTTGTCAATACA
    GGTATGTATACTGAAGTTGGTCATATTGCTGGTATGCTTCAAGATGCGGATGAGACTGAT
    ACACCACTCAAACAAAACTTGAACAACCTTTCTAAGGTCTTGACCTATGCTATCTTGGTC
    ATTGCCCTTGTTACTTTTGTAGTGGGTGTCTTCATTCAAGGGAAAAATCCACTTGGTGAG
    TTGTTGACTTCTGTTGCCCTTGCTGTTGCAGCCATTCCAGAAGGACTTCCTGCTATCGTT
    ACCATCGTTCTTTCTCTTGGTACTCAAGTTTTGGCCAAACGACATTCCATCGTTCGTAAG
    TTGCCAGCAGTTGAAACACTTGGTTCAACTGAAATCATCGCTTCTGATAAGACTGGTACG
    CTGACTATGAACAAGATGACAGTCGAAAAAGTCTTCTACGATGCGGTTCTACATGACTCA
    GCTGATGATATTGAACTAGGTCTTGAAATGCCACTACTTCGTTCAGTTGTCTTGGCCAAT
    GATACGAAAATCGATGTGGAAGGTAACTTGATTGGTGACCCAACCGAAACAGCCTTTATC
    CAATATGCCTTGGACAAGGGCTATGATGTCAAAGGTTTCTTAGAGAAATATCCTCGTGTA
    GCTGAATTGCCATTTGACTCTGACCGTAAGCTCATGTCAACAGTTCACCCATTGCCAGAT
    AGTCGTTTCCTTGTAGCAGTCAAGGGTGCGCCAGACCAACTCTTAAAACGTTGTCTTCTT
    CGTGATAAGGCTGGGGATATTGCTCCGATTGATGAGAAGGTTACAAATCTCATTCATACA
    AACAATTCTGAAATGGCTCATCAAGCCTTGCGTGTCCTTGCAGGTGCTTATAAGATTATC
    GATAGTATTCCAGAAAATCTCACTTCTGAAGAGCTTGAAAATGATTTAATTTTTACTGGT
    TTGATTGGGATGATTGACCCTGAACGTCCTGAAGCCGCTGAGGCTGTTCGTGTGGCTAAG
    GAAGCGGGAATCCGTCCAATTATGATTACAGGTGACCACCAAGACACAGCGGAAGCCATT
    GCCAAACGTTTGGGAATCATTGACGCAAACGATACAGAAGGTCACGTTTTAACTGGTGCT
    GAACTCAATGAACTGTCAGATGAAGAATTTGAAAAAGTTGTTGGTCAATACTCTGTTTAT
    GCCCGTGTGTCTCCAGAACACAAGGTTCGTATCGTCAAGGCTTGGCAAAAACAAGGTAAA
    GTCGTTGCCATGACAGGTGACGGTGTCAATGACGCGCCAGCTCTGAAAACAGCCGATATT
    GGTATCGGTATGGGAATCACTGGTACAGAGGTTTCTAAGGGGGCTTCTGATATGATTCTT
    GCAGATGATAACTTTGCGACTATTATCGTCGCAGTGGAAGAAGGACGTAAGGTCTTCTCA
    AACATTCAAAAGACTATTCAGTACCTACTTTCTGCTAATACTGCTGAAGTATTAACCATC
    TTCCTATCAACCTTGTTTGGTTGGGATGTCTTGCAGCCGGTTCATCTTTTGTGGATCAAC
    TTGGTAACGGATACCTTCCCAGCTATCGCTCTTGGTGTTGAACCTGCGGAACCTGGTGTC
    ATGAATCATAAACCACGTGGACGCAAGGCAAGCTTCTTCTCAGGTGGTGTTTTGAGTTCT
    ATCATTTATCAAGGTGTACTCCAAGCAGCTCTTGTTATGAGTGTTTATGGCCTTGCGATT
    GCTTACCCAGTTCATGTGGGTGACAATCATGCTATTCATGCAGATGCCCTAACGATGGCC
    TTTGCAACCCTTGGTTTGATTCAGCTCTTCCATGCCTACAATGTCAAGTCTGTCTACCAA
    TCCATCTTGACAGTTGGCCCATTCAAGTCTAAGACCTTTAACTGGTCCATCTTGGTATCC
    TTTATCCTTCTCATGGCAACAATCGTTGTAGAACCGCTTGAAGGAATCTTCCACGTAACC
    AAACTAGACTTGTCACAATGGGGAATTGTTATGGCTGGAAGCTTCTCAATGATTATCATC
    GTCGAAATCGTTAAGTTTATTCAACGCAAACTCGGTTTTGACAAGAATGCGATTTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1980
    2040
    2100
    2160
    2220
    2280
    2340
    2400
    2460
    2520
    2580
    2640
    2697

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPR_RS07005 [old locus tag: spr1410 ]
  • symbol: SPR_RS07005
  • description: cation-translocating P-type ATPase
  • length: 898
  • theoretical pI: 4.60666
  • theoretical MW: 97039.3
  • GRAVY: 0.216592

⊟Function[edit | edit source]

  • TIGRFAM:
    calcium-transporting P-type ATPase, PMR1-type (TIGR01522; EC 3.6.3.8; HMM-score: 692.6)
    Metabolism Transport and binding proteins Cations and iron carrying compounds calcium-translocating P-type ATPase, SERCA-type (TIGR01116; EC 3.6.3.8; HMM-score: 652.9)
    and 19 more
    potassium/sodium efflux P-type ATPase, fungal-type (TIGR01523; EC 3.6.3.-; HMM-score: 536.2)
    Metabolism Energy metabolism ATP-proton motive force interconversion Na,H/K antiporter P-type ATPase, alpha subunit (TIGR01106; EC 3.6.3.-; HMM-score: 481.3)
    calcium-translocating P-type ATPase, PMCA-type (TIGR01517; EC 3.6.3.8; HMM-score: 480.3)
    plasma-membrane proton-efflux P-type ATPase (TIGR01647; EC 3.6.3.6; HMM-score: 435.1)
    Metabolism Transport and binding proteins Cations and iron carrying compounds magnesium-translocating P-type ATPase (TIGR01524; EC 3.6.3.2; HMM-score: 430)
    HAD ATPase, P-type, family IC (TIGR01494; EC 3.6.3.-; HMM-score: 325.1)
    heavy metal translocating P-type ATPase (TIGR01525; EC 3.6.3.-; HMM-score: 245.5)
    P-type ATPase of unknown pump specificity (type V) (TIGR01657; HMM-score: 227.3)
    Metabolism Transport and binding proteins Cations and iron carrying compounds cadmium-translocating P-type ATPase (TIGR01512; EC 3.6.3.3; HMM-score: 185)
    Cellular processes Cellular processes Detoxification copper-translocating P-type ATPase (TIGR01511; EC 3.6.3.4; HMM-score: 178)
    Metabolism Transport and binding proteins Cations and iron carrying compounds copper-translocating P-type ATPase (TIGR01511; EC 3.6.3.4; HMM-score: 178)
    Metabolism Transport and binding proteins Cations and iron carrying compounds K+-transporting ATPase, B subunit (TIGR01497; EC 3.6.3.12; HMM-score: 132.3)
    phospholipid-translocating P-type ATPase, flippase (TIGR01652; EC 3.6.3.1; HMM-score: 98.9)
    Unknown function Enzymes of unknown specificity HAD phosphoserine phosphatase-like hydrolase, family IB (TIGR01488; HMM-score: 34.1)
    Metabolism Amino acid biosynthesis Serine family phosphoserine phosphatase SerB (TIGR00338; EC 3.1.3.3; HMM-score: 24.7)
    Unknown function Enzymes of unknown specificity Cof-like hydrolase (TIGR00099; HMM-score: 20.9)
    phosphoserine phosphatase-like hydrolase, archaeal (TIGR01491; HMM-score: 17)
    phosphoglycolate phosphatase, TA0175-type (TIGR01487; EC 3.1.3.18; HMM-score: 15.8)
    mannosyl-3-phosphoglycerate phosphatase family (TIGR01486; EC 3.1.3.-; HMM-score: 11.4)
  • TheSEED: see spr1410
  • PFAM:
    no clan defined E1-E2_ATPase; E1-E2 ATPase (PF00122; HMM-score: 181.1)
    Cation_ATPase_C; Cation transporting ATPase, C-terminus (PF00689; HMM-score: 156.8)
    and 7 more
    HAD (CL0137) Hydrolase; haloacid dehalogenase-like hydrolase (PF00702; HMM-score: 93.2)
    no clan defined Cation_ATPase_N; Cation transporter/ATPase, N-terminus (PF00690; HMM-score: 73.6)
    HAD (CL0137) Cation_ATPase; Cation transport ATPase (P-type) (PF13246; HMM-score: 72)
    HAD; haloacid dehalogenase-like hydrolase (PF12710; HMM-score: 31.3)
    Hydrolase_3; haloacid dehalogenase-like hydrolase (PF08282; HMM-score: 14.7)
    Hydrolase_6; haloacid dehalogenase-like hydrolase (PF13344; HMM-score: 14.5)
    no clan defined Suc_Fer-like; Sucrase/ferredoxin-like (PF06999; HMM-score: 11.4)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 9.99
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 8
  • DeepLocPro: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 0.9998
    • Cell wall & surface Score: 0
    • Extracellular Score: 0.0002
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.005092
    • TAT(Tat/SPI): 0.000414
    • LIPO(Sec/SPII): 0.00096
  • predicted transmembrane helices (TMHMM): 8

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MSKEQKRQAFYTQSPEEVLQAVDATEQGLSSSEAEKRLAEFGHNELEEGEKRSILVKFIEQFKDLMIIILVAAAILSVVTSGGEDIADAIIILAVVIINAAFGVYQEGKAEEAIEALKSMSSPVARVLRDGHMAEIDSKELVPGDIVALEAGDVVPADLRLIEANSLKIEEAALTGESVPVEKDLSVDLATDAGIGDRVNMAFQNSNVTYGRGMGVVVNTGMYTEVGHIAGMLQDADETDTPLKQNLNNLSKVLTYAILVIALVTFVVGVFIQGKNPLGELLTSVALAVAAIPEGLPAIVTIVLSLGTQVLAKRHSIVRKLPAVETLGSTEIIASDKTGTLTMNKMTVEKVFYDAVLHDSADDIELGLEMPLLRSVVLANDTKIDVEGNLIGDPTETAFIQYALDKGYDVKGFLEKYPRVAELPFDSDRKLMSTVHPLPDSRFLVAVKGAPDQLLKRCLLRDKAGDIAPIDEKVTNLIHTNNSEMAHQALRVLAGAYKIIDSIPENLTSEELENDLIFTGLIGMIDPERPEAAEAVRVAKEAGIRPIMITGDHQDTAEAIAKRLGIIDANDTEGHVLTGAELNELSDEEFEKVVGQYSVYARVSPEHKVRIVKAWQKQGKVVAMTGDGVNDAPALKTADIGIGMGITGTEVSKGASDMILADDNFATIIVAVEEGRKVFSNIQKTIQYLLSANTAEVLTIFLSTLFGWDVLQPVHLLWINLVTDTFPAIALGVEPAEPGVMNHKPRGRKASFFSGGVLSSIIYQGVLQAALVMSVYGLAIAYPVHVGDNHAIHADALTMAFATLGLIQLFHAYNVKSVYQSILTVGPFKSKTFNWSILVSFILLMATIVVEPLEGIFHVTKLDLSQWGIVMAGSFSMIIIVEIVKFIQRKLGFDKNAI

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

  1. ↑ Jane A Thanassi, Sandra L Hartman-Neumann, Thomas J Dougherty, Brian A Dougherty, Michael J Pucci
    Identification of 113 conserved essential genes using a high-throughput gene disruption system in Streptococcus pneumoniae.
    Nucleic Acids Res: 2002, 30(14);3152-62
    [PubMed:12136097] [WorldCat.org] [DOI] (I p)

⊟Relevant publications[edit | edit source]

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