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serotype 4
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serotype 1
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serotype 2
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Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 25-NOV-2024

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae R6
  • locus tag: SPR_RS07465 [old locus tag: spr1505 ]
  • pan locus tag?: PNEUPAN003077000
  • symbol: divIVA
  • pan gene symbol?: divIVA
  • synonym:
  • product: cell division protein DivIVA

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPR_RS07465 [old locus tag: spr1505 ]
  • symbol: divIVA
  • product: cell division protein DivIVA
  • replicon: chromosome
  • strand: -
  • coordinates: 1483605..1484393
  • length: 789
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    ATGCCAATTACATCATTAGAAATAAAGGACAAGACTTTTGGAACTCGATTCAGAGGTTTT
    GATCCAGAAGAAGTCGATGAATTTTTAGATATTGTGGTTCGTGATTACGAAGATCTTGTG
    CGTGCGAATCATGATAAAAATTTGCGTATTAAGAGTTTAGAAGAGCGTTTGTCTTACTTT
    GATGAAATAAAAGATTCATTGAGCCAGTCTGTATTGATTGCTCAGGATACAGCTGAGAGA
    GTGAAACAGGCGGCGCATGAACGTTCAAACAATATCATTCATCAAGCAGAGCAAGATGCG
    CAACGCTTGTTGGAAGAAGCTAAATATAAGGCAAACGAGATTCTTCGTCAAGCAACTGAT
    AATGCTAAGAAAGTCGCTGTTGAAACAGAAGAATTGAAGAACAAGAGCCGTGTCTTCCAC
    CAACGTCTCAAATCTACAATTGAGAGTCAGTTGGCTATTGTTGAATCTTCAGATTGGGAA
    GATATTCTCCGTCCAACAGCTACTTATCTTCAAACCAGTGATGAAGCCTTTAAAGAAGTG
    GTTAGCGAAGTACTTGGAGAACCGATTCCAGCTCCAATTGAAGAAGAACCAATTGATATG
    ACACGTCAGTTCTCTCAAGCAGAAATGGAAGAATTACAAGCTCGTATTGAGGTAGCCGAT
    AAAGAATTGTCTGAATTTGAAGCTCAGATTAAACAGGAAGTGGAAACTCCAACTCCTGTA
    GTGAGTCCTCAAGTTGAAGAAGAGCCTCTGCTCATCCAGTTGGCCCAATGTATGAAGAAC
    CAGAAGTAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    789

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPR_RS07465 [old locus tag: spr1505 ]
  • symbol: DivIVA
  • description: cell division protein DivIVA
  • length: 262
  • theoretical pI: 4.33649
  • theoretical MW: 30184.6
  • GRAVY: -0.669084

⊟Function[edit | edit source]

  • TIGRFAM:
    DivIVA domain (TIGR03544; HMM-score: 49.9)
    and 6 more
    HflK protein (TIGR01933; HMM-score: 23.8)
    ATP synthase archaeal, H subunit (TIGR02926; EC 3.6.3.14; HMM-score: 17.9)
    Metabolism Transport and binding proteins Other daunorubicin resistance ABC transporter, ATP-binding protein (TIGR01188; HMM-score: 14)
    Metabolism Energy metabolism ATP-proton motive force interconversion ATP synthase F0, B subunit (TIGR01144; EC 3.6.3.14; HMM-score: 10.6)
    Cellular processes Cellular processes Pathogenesis type III secretion apparatus protein, HrpE/YscL family (TIGR02499; HMM-score: 4.6)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking type III secretion apparatus protein, HrpE/YscL family (TIGR02499; HMM-score: 4.6)
  • TheSEED: see spr1505
  • PFAM:
    no clan defined DivIVA; DivIVA protein (PF05103; HMM-score: 129.8)
    and 16 more
    ATP_synthase (CL0255) HrpE; HrpE/YscL/FliH and V-type ATPase subunit E (PF06188; HMM-score: 20.8)
    no clan defined Med2; Mediator complex subunit 2 (PF11214; HMM-score: 15)
    YlqD; YlqD protein (PF11068; HMM-score: 12.2)
    CSN5_C; Cop9 signalosome subunit 5 C-terminal domain (PF18323; HMM-score: 11.4)
    SlyX; SlyX (PF04102; HMM-score: 11.3)
    KfrA_N; Plasmid replication region DNA-binding N-term (PF11740; HMM-score: 11.3)
    ATP_synthase (CL0255) V-ATPase_G_2; Vacuolar (H+)-ATPase G subunit (PF16999; HMM-score: 10.6)
    no clan defined DUF3135; Protein of unknown function (DUF3135) (PF11333; HMM-score: 9.9)
    Actin_ATPase (CL0108) FtsA; Cell division protein FtsA (PF14450; HMM-score: 9.3)
    ATP_synthase (CL0255) ATP-synt_B; ATP synthase B/B' CF(0) (PF00430; HMM-score: 9.2)
    vATP-synt_E; ATP synthase (E/31 kDa) subunit (PF01991; HMM-score: 7.9)
    PDDEXK (CL0236) Tox-REase-5; Restriction endonuclease fold toxin 5 (PF15648; HMM-score: 7.6)
    no clan defined BEX; Brain expressed X-linked like family (PF04538; HMM-score: 7.1)
    ATP_synthase (CL0255) V-ATPase_G; Vacuolar (H+)-ATPase G subunit (PF03179; HMM-score: 7)
    no clan defined YtxH; YtxH-like protein (PF12732; HMM-score: 7)
    CorA; CorA-like Mg2+ transporter protein (PF01544; HMM-score: 6.2)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9914
    • Cytoplasmic Membrane Score: 0.0043
    • Cell wall & surface Score: 0.0002
    • Extracellular Score: 0.0041
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.00129
    • TAT(Tat/SPI): 0.000191
    • LIPO(Sec/SPII): 0.000284
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MPITSLEIKDKTFGTRFRGFDPEEVDEFLDIVVRDYEDLVRANHDKNLRIKSLEERLSYFDEIKDSLSQSVLIAQDTAERVKQAAHERSNNIIHQAEQDAQRLLEEAKYKANEILRQATDNAKKVAVETEELKNKSRVFHQRLKSTIESQLAIVESSDWEDILRPTATYLQTSDEAFKEVVSEVLGEPIPAPIEEEPIDMTRQFSQAEMEELQARIEVADKELSEFEAQIKQEVETPTPVVSPQVEEEPLLIQLAQCMKNQK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Aurore Fleurie, Sylvie Manuse, Chao Zhao, Nathalie Campo, Caroline Cluzel, Jean-Pierre Lavergne, Céline Freton, Christophe Combet, Sébastien Guiral, Boumediene Soufi, Boris Macek, Erkin Kuru, Michael S VanNieuwenhze, Yves V Brun, Anne-Marie Di Guilmi, Jean-Pierre Claverys, Anne Galinier, Christophe Grangeasse
Interplay of the serine/threonine-kinase StkP and the paralogs DivIVA and GpsB in pneumococcal cell elongation and division.
PLoS Genet: 2014, 10(4);e1004275
[PubMed:24722178] [WorldCat.org] [DOI] (I e)

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