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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 06-SEP-2024

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae D39V
  • locus tag: SPV_0360 [new locus tag: SPV_RS01950 ]
  • pan locus tag?: PNEUPAN001238000
  • symbol: mtlA
  • pan gene symbol?: mtlA
  • synonym:
  • product: Mannitol-specific PTS IIBC components

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPV_0360 [new locus tag: SPV_RS01950 ]
  • symbol: mtlA
  • product: Mannitol-specific PTS IIBC components
  • replicon: chromosome
  • strand: +
  • coordinates: 361746..363515
  • length: 1770
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Location: CP027540 (361746..363515) NCBI
  • BioCyc: SPV_0360 BioCyc
  • MicrobesOnline:
  • PneumoBrowse: SPV_0360 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    ATGGAAGAAAAAGTATCATTGAAAGTCAGGGTTCAAAAACTAGGGACATCGCTTTCAAAT
    ATGGTTATGCCCAATATTGGAGCATTTATTGCTTGGGGAGTATTGACTGCCCTCTTTATC
    GCTGATGGCTATCTGCCAAATGAACAGTTAGCTACTGTTGTTGGTCCTATGTTAACGTAT
    TTATTGCCAATCCTGATTGGTTACACAGGTGGATATATGATCCATGGCCAACGTGGTGCC
    GTTGTAGGATCTATTGCTACTGTTGGTGCAATCACAGGTTCTAGTGTTCCTATGTTTATC
    GGAGCTATGGTAATGGGCCCACTGGGAGGATGGACTATCAAGAAATTTGATGAGAAGTTC
    CAAGAAAAAATTCGTCCCGGATTTGAAATGTTAGTTAATAACTTCTCAGCTGGTCTCGTT
    GGTTTTGCATTATTGCTTTTGGCTTTCTACGCAATCGGTCCAGTCGTATCGACTCTTACT
    GGAGCTGTTGGGAATGGTGTTGAGGCTATTGTCAATGCTCGCCTCCTTCCTATGGCTAAT
    ATTATCATCGAACCGGCTAAAGTCCTTTTCCTCAATAATGCCCTCAATCATGGCATTTTT
    ACTCCTCTGGGAGTAGAACAGGTAGCTCAAGCTGGTAAGTCAATTCTCTTCCTATTGGAA
    GCTAATCCTGGACCAGGCCTGGGAATTCTATTAGCTTATGCTGTATTCGGTAAAGGTTCT
    GCTAAATCTTCTTCTTGGGGGGCAATGGTTATTCATTTCTTCGGAGGGATTCATGAAATT
    TACTTTCCTTATGTTATGATGAAGCCTACTCTATTTTTAGCTGCTATGGCAGGAGGTATC
    TCTGGAACTTTTACTTTTCAACTCTTAGACGCTGGTCTTAAATCTCCAGCTTCACCAGGT
    TCTATTATTGCGATTATGGCTACGGCGCCAAAAGGTGTTTGGCCCCATCTAAATATTCTT
    TTAGGTGTTTTAGTGGCAGCAGTTGTTTCTTTCCTTATAGCAGCCCTTATTCTTCATGCA
    GACAAGTCAACTGAGGATTCGCTCGAAGCTGCTCAGGCGGCTACCCAAGCAGCTAAGGCT
    CAGTCTAAAGGTCAGTTAGTATCAACTTCTGTTGATGCAGTTGTTTCGACAGACTCAGTG
    GAAAAAATCATTTTCGCCTGCGATGCTGGTATGGGAAGCTCTGCTATGGGAGCTAGTATT
    CTTCGAGATAAGGTTAAAAAAGCAGGTCTAGAGCTTCCAGTATCTAATCAGGCAATCTCA
    AATTTGCTTGATACACCAAAAACATTAATTGTTACTCAGGAAGAACTGACACCAAGAGCT
    AAAGACAAGAGTCCAAGTGCTATTCATGTTTCTGTTGATAATTTCTTAGCGTCCCCTCGT
    TATGATGAAATTGTAGCTTCATTAACAGGAGCTTCTCCAATAGCAGAAATTGAAGGAGAT
    ATACCAACTTCAGCACCAGTAGATAGTCAGGAAATTGACCTTAACCATATTGATGCTGTA
    GTAGTTGCTTATGGTAAAGCACAGGGAACTGCAACTATGGGCTGTGAAACGATTCGGGCT
    ATCTTTAGAAACAAGAATATTCGTATTCCAGTTTCTACTGCCAAAATTTCAGAATTAGGT
    GAATTTAATTCTAAAAACATAATGATTGTAACAACTATTTCTTTACAGGCAGAAGTGCAG
    CAAGCAGCACCGAATTCTCAATTTCTTATTGTGGATAGTTTAGTAACAACACCAGAATAT
    GACAAAATGGCTGCTAGAATGTACAAATAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1770

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPV_0360 [new locus tag: SPV_RS01950 ]
  • symbol: MtlA
  • description: Mannitol-specific PTS IIBC components
  • length: 589
  • theoretical pI: 6.52385
  • theoretical MW: 61952.9
  • GRAVY: 0.444991

⊟Function[edit | edit source]

  • reaction:
    EC 2.7.1.197?  ExPASy
    Protein-N(pi)-phosphohistidine--D-mannitol phosphotransferase [Protein]-N(pi)-phospho-L-histidine + D-mannitol(Side 1) = [protein]-L-histidine + D-mannitol 1-phosphate(Side 2)
  • TIGRFAM:
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids PTS system, mannitol-specific IIC component (TIGR00851; EC 2.7.1.69; HMM-score: 517)
    Signal transduction Signal transduction PTS PTS system, mannitol-specific IIC component (TIGR00851; EC 2.7.1.69; HMM-score: 517)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    PTS_EIIC (CL0493) PTS_EIIC; Phosphotransferase system, EIIC (PF02378; HMM-score: 66.2)
    and 1 more
    Phosphatase (CL0031) PTS_IIB; PTS system, Lactose/Cellobiose specific IIB subunit (PF02302; HMM-score: 33.6)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 6
  • DeepLocPro: Cytoplasmic Membrane
    • Cytoplasmic Score: 0.0007
    • Cytoplasmic Membrane Score: 0.9932
    • Cell wall & surface Score: 0.0001
    • Extracellular Score: 0.006
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.01384
    • TAT(Tat/SPI): 0.001177
    • LIPO(Sec/SPII): 0.003684
  • predicted transmembrane helices (TMHMM): 8

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: AVN85523 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MEEKVSLKVRVQKLGTSLSNMVMPNIGAFIAWGVLTALFIADGYLPNEQLATVVGPMLTYLLPILIGYTGGYMIHGQRGAVVGSIATVGAITGSSVPMFIGAMVMGPLGGWTIKKFDEKFQEKIRPGFEMLVNNFSAGLVGFALLLLAFYAIGPVVSTLTGAVGNGVEAIVNARLLPMANIIIEPAKVLFLNNALNHGIFTPLGVEQVAQAGKSILFLLEANPGPGLGILLAYAVFGKGSAKSSSWGAMVIHFFGGIHEIYFPYVMMKPTLFLAAMAGGISGTFTFQLLDAGLKSPASPGSIIAIMATAPKGVWPHLNILLGVLVAAVVSFLIAALILHADKSTEDSLEAAQAATQAAKAQSKGQLVSTSVDAVVSTDSVEKIIFACDAGMGSSAMGASILRDKVKKAGLELPVSNQAISNLLDTPKTLIVTQEELTPRAKDKSPSAIHVSVDNFLASPRYDEIVASLTGASPIAEIEGDIPTSAPVDSQEIDLNHIDAVVVAYGKAQGTATMGCETIRAIFRNKNIRIPVSTAKISELGEFNSKNIMIVTTISLQAEVQQAAPNSQFLIVDSLVTTPEYDKMAARMYK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulators: CcpA regulon, MtlR (activation) regulon
    CcpA(TF)important in Global catabolite repression;  – regulation transferred from D39 see SPD_0360
    MtlR(TF)important in Mannitol utilization;  – regulation transferred from D39 see SPD_0360

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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