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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 08-SEP-2024

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae D39V
  • locus tag: SPV_RS00695 [old locus tag: SPV_0126 ]
  • pan locus tag?: PNEUPAN000791000
  • symbol: pspA
  • pan gene symbol?: pspA
  • synonyms: cbpA, pspC
  • product: pneumococcal surface protein A

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPV_RS00695 [old locus tag: SPV_0126 ]
  • symbol: pspA
  • product: pneumococcal surface protein A
  • replicon: chromosome
  • strand: +
  • coordinates: 128812..130671
  • length: 1860
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    ATGAATAAGAAAAAAATGATTTTAACAAGTCTAGCCAGCGTCGCTATCTTAGGGGCTGGT
    TTTGTTGCGTCTCAGCCTACTGTTGTAAGAGCAGAAGAATCTCCCGTAGCCAGTCAGTCT
    AAAGCTGAGAAAGACTATGATGCAGCGAAGAAAGATGCTAAGAATGCGAAAAAAGCAGTA
    GAAGATGCTCAAAAGGCTTTAGATGATGCAAAAGCTGCTCAGAAAAAATATGACGAGGAT
    CAGAAGAAAACTGAGGAGAAAGCCGCGCTAGAAAAAGCAGCGTCTGAAGAGATGGATAAG
    GCAGTGGCAGCAGTTCAACAAGCGTATCTAGCCTATCAACAAGCTACAGACAAAGCCGCA
    AAAGACGCAGCAGATAAGATGATAGATGAAGCTAAGAAACGCGAAGAAGAGGCAAAAACT
    AAATTTAATACTGTTCGAGCAATGGTAGTTCCTGAGCCAGAGCAGTTGGCTGAGACTAAG
    AAAAAATCAGAAGAAGCTAAACAAAAAGCACCAGAACTTACTAAAAAACTAGAAGAAGCT
    AAAGCAAAATTAGAAGAGGCTGAGAAAAAAGCTACTGAAGCCAAACAAAAAGTGGATGCT
    GAAGAAGTCGCTCCTCAAGCTAAAATCGCTGAATTGGAAAATCAAGTTCATAGACTAGAA
    CAAGAGCTCAAAGAGATTGATGAGTCTGAATCAGAAGATTATGCTAAAGAAGGTTTCCGT
    GCTCCTCTTCAATCTAAATTGGATGCCAAAAAAGCTAAACTATCAAAACTTGAAGAGTTA
    AGTGATAAGATTGATGAGTTAGACGCTGAAATTGCAAAACTTGAAGATCAACTTAAAGCT
    GCTGAAGAAAACAATAATGTAGAAGACTACTTTAAAGAAGGTTTAGAGAAAACTATTGCT
    GCTAAAAAAGCTGAATTAGAAAAAACTGAAGCTGACCTTAAGAAAGCAGTTAATGAGCCA
    GAAAAACCAGCTCCAGCTCCAGAAACTCCAGCCCCAGAAGCACCAGCTGAACAACCAAAA
    CCAGCGCCGGCTCCTCAACCAGCTCCCGCACCAAAACCAGAGAAGCCAGCTGAACAACCA
    AAACCAGAAAAAACAGATGATCAACAAGCTGAAGAAGACTATGCTCGTAGATCAGAAGAA
    GAATATAATCGCTTGACTCAACAGCAACCGCCAAAAGCTGAAAAACCAGCTCCTGCACCA
    AAAACAGGCTGGAAACAAGAAAACGGTATGTGGTACTTCTACAATACTGATGGTTCAATG
    GCGACAGGATGGCTCCAAAACAACGGTTCATGGTACTACCTCAACAGCAATGGTGCTATG
    GCTACAGGTTGGCTCCAATACAATGGTTCATGGTATTACCTCAACGCTAACGGCGCTATG
    GCAACAGGTTGGGCTAAAGTCAACGGTTCATGGTACTACCTCAACGCTAATGGTGCTATG
    GCTACAGGTTGGCTCCAATACAACGGTTCATGGTATTACCTCAACGCTAACGGCGCTATG
    GCAACAGGTTGGGCTAAAGTCAACGGTTCATGGTACTACCTCAACGCTAATGGTGCTATG
    GCTACAGGTTGGCTCCAATACAACGGTTCATGGTACTACCTCAACGCTAACGGTGCTATG
    GCTACAGGTTGGGCTAAAGTCAACGGTTCATGGTACTACCTCAACGCTAATGGTGCTATG
    GCAACAGGTTGGGTGAAAGATGGAGATACCTGGTACTATCTTGAAGCATCAGGTGCTATG
    AAAGCAAGCCAATGGTTCAAAGTATCAGATAAATGGTACTATGTCAATGGTTTAGGTGCC
    CTTGCAGTCAACACAACTGTAGATGGCTATAAAGTCAATGCCAATGGTGAATGGGTTTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPV_RS00695 [old locus tag: SPV_0126 ]
  • symbol: PspA
  • description: pneumococcal surface protein A
  • length: 619
  • theoretical pI: 4.82307
  • theoretical MW: 68605
  • GRAVY: -0.886914

⊟Function[edit | edit source]

  • TIGRFAM:
    glucan-binding repeat (TIGR04035; HMM-score: 77.1)
    and 7 more
    Cellular processes Cellular processes Cell division chromosome segregation protein SMC (TIGR02168; HMM-score: 22.1)
    Genetic information processing DNA metabolism Chromosome-associated proteins chromosome segregation protein SMC (TIGR02168; HMM-score: 22.1)
    Cellular processes Cellular processes Cell division chromosome segregation protein SMC (TIGR02169; HMM-score: 9.9)
    Genetic information processing DNA metabolism Chromosome-associated proteins chromosome segregation protein SMC (TIGR02169; HMM-score: 9.9)
    two transmembrane protein (TIGR04527; HMM-score: 7.2)
    SEC10/PgrA surface exclusion domain (TIGR04320; HMM-score: 6.5)
    helix-rich protein (TIGR04523; HMM-score: 3.2)
  • TheSEED: data available for D39
  • PFAM:
    Choline_binding (CL0694) Choline_bind_1; Putative cell wall binding repeat (PF01473; HMM-score: 211.6)
    Choline_bind_3; Choline-binding repeat (PF19127; HMM-score: 193)
    and 5 more
    Choline_bind_2; Choline-binding repeat (PF19085; HMM-score: 53.8)
    no clan defined FH2; Formin Homology 2 Domain (PF02181; HMM-score: 15)
    HSBP1; Heat shock factor binding protein 1 (PF06825; HMM-score: 14.2)
    Med9; RNA polymerase II transcription mediator complex subunit 9 (PF07544; HMM-score: 10.6)
    EzrA; Septation ring formation regulator, EzrA (PF06160; HMM-score: 4.6)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Extracellular
    • Cytoplasmic Score: 0.01
    • Cytoplasmic Membrane Score: 0.09
    • Cellwall Score: 0.18
    • Extracellular Score: 9.72
    • Internal Helices: 0
  • DeepLocPro: Cell wall & surface
    • Cytoplasmic Score: 0.0036
    • Cytoplasmic Membrane Score: 0.0009
    • Cell wall & surface Score: 0.7912
    • Extracellular Score: 0.2043
  • SignalP: Signal peptide SP(Sec/SPI) length 31 aa
    • SP(Sec/SPI): 0.990009
    • TAT(Tat/SPI): 0.004717
    • LIPO(Sec/SPII): 0.004309
    • Cleavage Site: CS pos: 31-32. VRA-EE. Pr: 0.9389
  • predicted transmembrane helices (TMHMM): 1

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_001035315 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MNKKKMILTSLASVAILGAGFVASQPTVVRAEESPVASQSKAEKDYDAAKKDAKNAKKAVEDAQKALDDAKAAQKKYDEDQKKTEEKAALEKAASEEMDKAVAAVQQAYLAYQQATDKAAKDAADKMIDEAKKREEEAKTKFNTVRAMVVPEPEQLAETKKKSEEAKQKAPELTKKLEEAKAKLEEAEKKATEAKQKVDAEEVAPQAKIAELENQVHRLEQELKEIDESESEDYAKEGFRAPLQSKLDAKKAKLSKLEELSDKIDELDAEIAKLEDQLKAAEENNNVEDYFKEGLEKTIAAKKAELEKTEADLKKAVNEPEKPAPAPETPAPEAPAEQPKPAPAPQPAPAPKPEKPAEQPKPEKTDDQQAEEDYARRSEEEYNRLTQQQPPKAEKPAPAPKTGWKQENGMWYFYNTDGSMATGWLQNNGSWYYLNSNGAMATGWLQYNGSWYYLNANGAMATGWAKVNGSWYYLNANGAMATGWLQYNGSWYYLNANGAMATGWAKVNGSWYYLNANGAMATGWLQYNGSWYYLNANGAMATGWAKVNGSWYYLNANGAMATGWVKDGDTWYYLEASGAMKASQWFKVSDKWYYVNGLGALAVNTTVDGYKVNANGEWV

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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