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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae TIGR4
  • locus tag: SP_0112 [new locus tag: SP_RS00570 ]
  • pan locus tag?: PNEUPAN000789000
  • symbol: SP_0112
  • pan gene symbol?: artP_1
  • synonym:
  • product: putative amino acid ABC transporter, periplasmic amino acid-binding protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SP_0112 [new locus tag: SP_RS00570 ]
  • symbol: SP_0112
  • product: putative amino acid ABC transporter, periplasmic amino acid-binding protein
  • replicon: chromosome
  • strand: +
  • coordinates: 114086..114892
  • length: 807
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    ATGAATAAGATGAAGAAGGTGTTGATGACGATGTTTGGTTTAGTGATGCTCCCCCTACTA
    TTTGCTTGTAGCAACAATCAATCGGCTGGAATTGAAGCCATCAAGTCCAAAGGAAAATTG
    GTTGTAGCCCTCAATCCGGATTTTGCTCCATTTGAATACCAAAAAGTGGTTGATGGGAAA
    AATCAGATTGTGGGTTCAGATATCGAATTAGCCAAGGCTATCGCAACAAAACTAGGTGTC
    GAATTGGAACTATCTCCCATGAGTTTTGATAATGTACTGGCTAGTGTTCAATCAGGAAAA
    GCCGACCTTGCCATATCAGGTGTTTCTAAGACAGATGAACGGAGCAAGGTGTTTGACTTT
    TCCATTCCCTACTATACTGCAAAAAATAAACTCATTGTCAAAAAATCTGACTTGACTACT
    TATCAGTCTGTAAACGACTTGGCGCAGAAAAAGGTTGGAGCGCAGAAAGGTTCGATTCAA
    GAGACGATGGCGAAAGATTTGCTACAAAATTCTTCCCTCGTATCTCTGCCTAAAAATGGG
    AATTTAATCACAGATTTAAAATCAGGACAAGTGGATGCCGTTATCTTTGAAGAACCTGTT
    TCCAAGGGATTTGTGGAAAATAATCCTGATTTAGCAATCGCAGACCTCAATTTTGAAAAA
    GAGCAAGATGATTCCTACGCGGTAGCCATGAAAAAAGATAGCAAGAAATTGAAAGAGGCA
    GTCGATAAAACCATTCAAAAGTTGAAGGAGTCTGGGGAATTAGACAAACTCATTGAGGAT
    GCCTTTAAAGCATCCATTGAAAAATAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    807

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SP_0112 [new locus tag: SP_RS00570 ]
  • symbol: SP_0112
  • description: putative amino acid ABC transporter, periplasmic amino acid-binding protein
  • length: 268
  • theoretical pI: 6.88061
  • theoretical MW: 29264.6
  • GRAVY: -0.222388

⊟Function[edit | edit source]

  • TIGRFAM:
    Metabolism Transport and binding proteins Amino acids, peptides and amines lysine-arginine-ornithine-binding periplasmic protein (TIGR01096; HMM-score: 151.4)
    and 5 more
    Metabolism Transport and binding proteins Amino acids, peptides and amines ectoine/hydroxyectoine ABC transporter solute-binding protein EhuB (TIGR02995; HMM-score: 72.8)
    extracellular substrate-binding orphan protein, GRRM family (TIGR04262; HMM-score: 47.5)
    quinoprotein dehydrogenase-associated probable ABC transporter substrate-binding protein (TIGR03871; HMM-score: 35.1)
    Metabolism Transport and binding proteins Other ABC transporter, substrate-binding protein, aliphatic sulfonates family (TIGR01728; HMM-score: 22.7)
    Metabolism Amino acid biosynthesis Histidine family ATP phosphoribosyltransferase (TIGR00070; EC 2.4.2.17; HMM-score: 13.3)
  • TheSEED  :
    • Amino acid ABC transporter, amino acid-binding/permease protein
  • PFAM:
    PBP (CL0177) SBP_bac_3; Bacterial extracellular solute-binding proteins, family 3 (PF00497; HMM-score: 202.1)
    and 6 more
    Lig_chan-Glu_bd; Ligated ion channel L-glutamate- and glycine-binding site (PF10613; HMM-score: 30.3)
    NMT1; NMT1/THI5 like (PF09084; HMM-score: 22.8)
    no clan defined PMC2NT; PMC2NT (NUC016) domain (PF08066; HMM-score: 15.7)
    HSP20 (CL0190) Pih1_fungal_CS; Fungal Pih1 CS domain (PF18482; HMM-score: 14.3)
    PBP (CL0177) LysR_substrate; LysR substrate binding domain (PF03466; HMM-score: 12.9)
    PBP_like; PBP superfamily domain (PF12727; HMM-score: 11.9)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: unknown (no significant prediction)
    • Cytoplasmic Score: 2.5
    • Cytoplasmic Membrane Score: 2.5
    • Cellwall Score: 2.5
    • Extracellular Score: 2.5
    • Internal Helices: 0
  • SignalP: Signal peptide LIPO(Sec/SPII) length 22 aa
    • SP(Sec/SPI): 0.002989
    • TAT(Tat/SPI): 0.000081
    • LIPO(Sec/SPII): 0.996676
    • Cleavage Site: CS pos: 22-23. LFA-CS. Pr: 0.9972
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MNKMKKVLMTMFGLVMLPLLFACSNNQSAGIEAIKSKGKLVVALNPDFAPFEYQKVVDGKNQIVGSDIELAKAIATKLGVELELSPMSFDNVLASVQSGKADLAISGVSKTDERSKVFDFSIPYYTAKNKLIVKKSDLTTYQSVNDLAQKKVGAQKGSIQETMAKDLLQNSSLVSLPKNGNLITDLKSGQVDAVIFEEPVSKGFVENNPDLAIADLNFEKEQDDSYAVAMKKDSKKLKEAVDKTIQKLKESGELDKLIEDAFKASIEK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulators: ArgR2* (activation (repression)) regulon, AhrC* (activation (repression)) regulon, ArgR1/ArgR* (activation (repression)) regulon
    ArgR2*(TF)important in Arginine biosynthesis, Arginine degradation; RegPrecise 
    AhrC*(TF)important in Arginine biosynthesis, Arginine degradation; RegPrecise 
    ArgR1/ArgR*(TF)important in Arginine biosynthesis, Arginine degradation; RegPrecise 

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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