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JJA
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MDRSPN001
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NCTC7466
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NU83127
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OXC141
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SPN032672
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SPN034183
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SPN994038
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SPN994039
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SPNA45
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TCH8431/19A
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serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae TIGR4
  • locus tag: SP_0283 [new locus tag: SP_RS01390 ]
  • pan locus tag?: PNEUPAN001031000
  • symbol: manM
  • pan gene symbol?: manM
  • synonym:
  • product: PTS system, mannose-specific IIC component

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SP_0283 [new locus tag: SP_RS01390 ]
  • symbol: manM
  • product: PTS system, mannose-specific IIC component
  • replicon: chromosome
  • strand: -
  • coordinates: 260854..261657
  • length: 804
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    ATGTCTATTATTTCTATGGTTTTAGTAGTCGTTGTAGCCTTCTTTGCAGGTCTTGAAGGC
    ATCCTCGACCAGTTCCAATTTCACCAACCACTTGTAGCCTGTACCCTTATTGGGCTTGTA
    ACAGGTCACTTGGAAGCAGGGATTATCCTCGGTGGATCGCTTCAAATGATTGCCCTTGGT
    TGGTCAAATATCGGTGCTGCTATCGCTCCTGATGCTGCACTTGCTTCTGTCGCTGCTGCC
    ATTATCATGGTTCTTGGTGGTGACTTTACCAAGACTGGTATCGGTGTTGCCCAAGCGGTT
    GCTATCCCTCTTGCTGTAGCTGGACTTTTCTTGACAATGATTGTTCGTACAATTTCAGTT
    GGTTTGGTTCATACTGCAGATGCTGCCGCTAAAAAAGGTGACTTCGGCGCTGTGGAGCGT
    GCGCATTTCATCGCGCTACTTTTCCAAGGACTTCGTATCGCGCTTCCTGCAGCTCTTCTC
    CTTATGGTACCAACTGAAACTGTACAAAGTATCCTTAGTGCCATGCCAGACTGGCTCAAA
    GATGGTATGGCTATCGGTGGTGGTATGGTCGTTGCCGTTGGTTACGCCATGGTTATCAAC
    ATGATGGCAACTCGTGAAGTATGGCCATTCTTCGCTCTTGGTTTCGTTCTCGCTGCTGTG
    TCAGATATTACTCTAATCGGATTCGGTGCTATCGGCGTTGCTATCGCTCTTATCTACCTT
    CACCTTTCTAAAACTGGTGGAAATGGTGGCGGAGGAGCCGCAACTTCTAACGACCCAATC
    GGCGATATCCTAGAAGACTACTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    804

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SP_0283 [new locus tag: SP_RS01390 ]
  • symbol: ManM
  • description: PTS system, mannose-specific IIC component
  • length: 267
  • theoretical pI: 4.64861
  • theoretical MW: 27230.2
  • GRAVY: 1.07566

⊟Function[edit | edit source]

  • TIGRFAM:
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids PTS system, mannose/fructose/sorbose family, IIC component (TIGR00822; HMM-score: 252.3)
    Signal transduction Signal transduction PTS PTS system, mannose/fructose/sorbose family, IIC component (TIGR00822; HMM-score: 252.3)
  • TheSEED  :
    • PTS system, mannose-specific IIC component
    Carbohydrates Monosaccharides Mannose Metabolism  PTS system, mannose-specific IIC component
    and 1 more
    Cell Wall and Capsule Capsular and extracellular polysacchrides Sialic Acid Metabolism  PTS system, mannose-specific IIC component
  • PFAM:
    no clan defined EII-Sor; PTS system sorbose-specific iic component (PF03609; HMM-score: 239.3)
    and 2 more
    Inovirus-Coat (CL0371) Phage_Coat_B; Inovirus Coat protein B (PF05356; HMM-score: 14)
    no clan defined NADH_dh_m_C1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial (PF15088; HMM-score: 12.2)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 7
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.039188
    • TAT(Tat/SPI): 0.000258
    • LIPO(Sec/SPII): 0.027591
  • predicted transmembrane helices (TMHMM): 7

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MSIISMVLVVVVAFFAGLEGILDQFQFHQPLVACTLIGLVTGHLEAGIILGGSLQMIALGWSNIGAAIAPDAALASVAAAIIMVLGGDFTKTGIGVAQAVAIPLAVAGLFLTMIVRTISVGLVHTADAAAKKGDFGAVERAHFIALLFQGLRIALPAALLLMVPTETVQSILSAMPDWLKDGMAIGGGMVVAVGYAMVINMMATREVWPFFALGFVLAAVSDITLIGFGAIGVAIALIYLHLSKTGGNGGGGAATSNDPIGDILEDY

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator: CcpA regulon
    CcpA(TF)important in Global catabolite repression; RegPrecise 

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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