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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae TIGR4
  • locus tag: SP_0285 [new locus tag: SP_RS01400 ]
  • pan locus tag?: PNEUPAN001033000
  • symbol: SP_0285
  • pan gene symbol?: adhA
  • synonym: adhP
  • product: alcohol dehydrogenase, zinc-containing

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SP_0285 [new locus tag: SP_RS01400 ]
  • symbol: SP_0285
  • product: alcohol dehydrogenase, zinc-containing
  • replicon: chromosome
  • strand: -
  • coordinates: 262907..263926
  • length: 1020
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    ATGAAAGCTGTTGTTGTAAATCCAGAAAGCACTGGTGTTGCTATTGAAGAAAAAGTACTC
    CGTCCACTTGAAACTGGGGAAGCACTTGTAGAAGTTGAATACTGTGGCGTTTGCCACACC
    GACCTCCACGTTGCTCATGGTGACTTTGGTCAAGTCCCAGGACGTGTTCTTGGGCACGAA
    GGTATCGGTATCGTTAAAGAGATTGCTCCAGATGTGAAAAGCCTTAAAGTCGGTGACCGC
    GTCAGCGTTGCTTGGTTCTTTGAAGGATGTGGCACTTGCGAATACTGTACAACTGGTCGC
    GAAACCCTTTGCCGTACAGTGAAAAATGCTGGCTACTCAGTAGACGGTGGTATGGCTGAA
    CAATGTATCGTAACTGCTGACTATGCTGTCAAAGTTCCTGACGGACTTGATCCAGCCCAA
    GCTTCTTCTATCACATGTGCTGGAGTAACAACCTATAAAGCTATCAAAGAAGCAAAAGTT
    GAACCAGGCCAATGGGTTGTTCTTTACGGTGCTGGTGGACTTGGTAACCTCGCTGTTCAA
    TACGCTAAAAAAGTATTCAATGCTCATGTTATCGCAGTCGATATCAACAATGACAAACTT
    GCCCTTGCAAAAGAAGTAGGCGCTGACATTGTGATTAACGGCCTCGAAGTTGAAGATGTA
    GCTGGACTCATTAAAGAAAAAACTGATGGAGGAGCTCATTCAGCTGTCGTAACTGCTGTG
    TCTAAAGTTGCCTTCAACCAGGCTGTTGACTCCATTCGTGCTGGTGGTCGCGTCGTCGCT
    GTTGGTCTTCCTTCTGAAATGATGGAACTCAGCATCGTTAAAACAGTCCTCGATGGAATC
    CAAGTCATCGGTTCTCTTGTCGGAACTCGTAAAGACTTAGAAGAAGCCTTCCAATTTGGT
    GCAGAAGGTCTGGTAGTCCCAGTTGTTCAAAAACGTCCAGTAGAAGATGCTGTTGCCATT
    TTCGACGAAATGGAAAAAGGCCAAATCCAAGGACGTATGGTACTCGACTTCACCCACTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SP_0285 [new locus tag: SP_RS01400 ]
  • symbol: SP_0285
  • description: alcohol dehydrogenase, zinc-containing
  • length: 339
  • theoretical pI: 4.69885
  • theoretical MW: 35749.8
  • GRAVY: 0.183481

⊟Function[edit | edit source]

  • reaction:
    EC 1.1.1.1?  ExPASy
    Alcohol dehydrogenase A primary alcohol + NAD+ = an aldehyde + NADH A secondary alcohol + NAD+ = a ketone + NADH
  • TIGRFAM:
    Metabolism Energy metabolism Fermentation zinc-binding alcohol dehydrogenase family protein (TIGR02822; EC 1.-.-.-; HMM-score: 150.4)
    Metabolism Energy metabolism Amino acids and amines L-threonine 3-dehydrogenase (TIGR00692; EC 1.1.1.103; HMM-score: 134.4)
    Unknown function Enzymes of unknown specificity NDMA-dependent alcohol dehydrogenase, Rxyl_3153 family (TIGR03989; EC 1.1.99.36; HMM-score: 127.9)
    Cellular processes Cellular processes Detoxification S-(hydroxymethyl)mycothiol dehydrogenase (TIGR03451; EC 1.1.1.306; HMM-score: 127.6)
    putative phosphonate catabolism associated alcohol dehydrogenase (TIGR03366; HMM-score: 123.1)
    and 10 more
    6-hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase (TIGR03201; EC 1.1.1.-; HMM-score: 117.1)
    Unknown function Enzymes of unknown specificity putative NAD(P)H quinone oxidoreductase, PIG3 family (TIGR02824; HMM-score: 103.7)
    Cellular processes Cellular processes Detoxification S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase (TIGR02818; EC 1.1.1.1,1.1.1.284; HMM-score: 99.5)
    Metabolism Energy metabolism Fermentation S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase (TIGR02818; EC 1.1.1.1,1.1.1.284; HMM-score: 99.5)
    Unknown function Enzymes of unknown specificity putative quinone oxidoreductase, YhdH/YhfP family (TIGR02823; HMM-score: 65.6)
    crotonyl-CoA carboxylase/reductase (TIGR01751; EC 1.3.1.85; HMM-score: 60.6)
    Metabolism Central intermediary metabolism One-carbon metabolism formaldehyde dehydrogenase, glutathione-independent (TIGR02819; EC 1.2.1.46; HMM-score: 60.1)
    Metabolism Energy metabolism Fermentation zinc-binding alcohol dehydrogenase family protein (TIGR02817; HMM-score: 48.2)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Menaquinone and ubiquinone ubiquinone/menaquinone biosynthesis methyltransferase (TIGR01934; EC 2.1.1.-; HMM-score: 13)
    Genetic information processing Protein fate Protein modification and repair methyltransferase, HemK family (TIGR00536; HMM-score: 11.2)
  • TheSEED  :
    • Alcohol dehydrogenase (EC 1.1.1.1)
    Carbohydrates Fermentation Fermentations: Lactate  Alcohol dehydrogenase (EC 1.1.1.1)
    and 2 more
    Carbohydrates Fermentation Fermentations: Mixed acid  Alcohol dehydrogenase (EC 1.1.1.1)
    Fatty Acids, Lipids, and Isoprenoids Phospholipids Glycerolipid and Glycerophospholipid Metabolism in Bacteria  Alcohol dehydrogenase (EC 1.1.1.1)
  • PFAM:
    GroES (CL0296) ADH_N; Alcohol dehydrogenase GroES-like domain (PF08240; HMM-score: 104.1)
    NADP_Rossmann (CL0063) ADH_zinc_N; Zinc-binding dehydrogenase (PF00107; HMM-score: 88.1)
    and 4 more
    ADH_zinc_N_2; Zinc-binding dehydrogenase (PF13602; HMM-score: 36.7)
    Methyltransf_25; Methyltransferase domain (PF13649; HMM-score: 15.1)
    Sacchrp_dh_NADP; Saccharopine dehydrogenase NADP binding domain (PF03435; HMM-score: 12.6)
    Methyltransf_31; Methyltransferase domain (PF13847; HMM-score: 11.7)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.009474
    • TAT(Tat/SPI): 0.000473
    • LIPO(Sec/SPII): 0.000942
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MKAVVVNPESTGVAIEEKVLRPLETGEALVEVEYCGVCHTDLHVAHGDFGQVPGRVLGHEGIGIVKEIAPDVKSLKVGDRVSVAWFFEGCGTCEYCTTGRETLCRTVKNAGYSVDGGMAEQCIVTADYAVKVPDGLDPAQASSITCAGVTTYKAIKEAKVEPGQWVVLYGAGGLGNLAVQYAKKVFNAHVIAVDINNDKLALAKEVGADIVINGLEVEDVAGLIKEKTDGGAHSAVVTAVSKVAFNQAVDSIRAGGRVVAVGLPSEMMELSIVKTVLDGIQVIGSLVGTRKDLEEAFQFGAEGLVVPVVQKRPVEDAVAIFDEMEKGQIQGRMVLDFTH

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulators: Rex* (repression) regulon, CcpA regulon
    Rex*(TF)important in Energy metabolism; RegPrecise 
    CcpA(TF)important in Global catabolite repression; RegPrecise 

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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