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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae TIGR4
  • locus tag: SP_0413 [new locus tag: SP_RS02045 ]
  • pan locus tag?: PNEUPAN001257000
  • symbol: SP_0413
  • pan gene symbol?: lysC
  • synonym:
  • product: aspartate kinase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SP_0413 [new locus tag: SP_RS02045 ]
  • symbol: SP_0413
  • product: aspartate kinase
  • replicon: chromosome
  • strand: -
  • coordinates: 392656..394020
  • length: 1365
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    ATGAAAGTTGTTAAATTTGGAGGTAGTTCTCTTGCCTCTGCTAGTCAATTAGAAAAAGTT
    TTAAACATCGTCAAAAGCGATTCAGAGCGTCGTTTTGTAGTCGTTTCTGCGCCTGGTAAA
    CGCAATGCTGAAGATACTAAGGTTACGGATGCCCTGATTAAATACTACCGCGACTATGTT
    GCGGGTAACGATATTAGCAAGAACCAAAGCTGGATTATCGACCGCTATGCTGCTATGGTT
    AGTGAATTGGGACTAAAACCAGCTGTGCTAGAAAAAATTTCTAAAAGCATTCACGCCTTG
    GCCACTCTTCCTATTGAAGAAAATGAATTTCTCTACGATACTTTCCTAGCAGCCGGTGAA
    AATAACAATGCCAAATTGATTGCTGCCTACTTTAACCAAAATGGTATCGATGCACGCTAT
    ATGCACCCTAGAGAAGCTGGGATTGTGGTCACAAGTGAACCTGGTCACGCTCGCATCATT
    CCATCAAGTTATGACAAGATTGAAGAATTGACAAACACCAATGAAGTCCTTGTCATTCCT
    GGTTTCTTTGGTGTCACTAAGGAAAATCAAATCTGTACTTTCTCACGTGGAGGTTCTGAT
    ATTACAGGTTCTATCATTGCTGCTGGTGTCAAAGCTGACCTCTATGAAAACTTTACGGAC
    GTTGATGGTATCTTTGCAGCCCACCCTGGTATTATCCACCAACCACACTCGATTCCTGAG
    TTGACCTACCGTGAAATGCGCGAGTTGGCCTATGCAGGCTTCTCAGTCCTTCATGACGAG
    GCTCTTCTTCCTGCCTACCGTGGAAAAATTCCTCTGGTTATCAAGAATACCAACAACCCT
    GACCATCCAGGTACTCGTATCGTTCTAAAACACAGTAATGATGAATTTCCAGTTGTGGGA
    ATTGCTGGTGACTCAGGCTTTGTCAGCATTAACATGTCGAAATACCTCATGAACCGTGAG
    GTTGGATTTGGCCGCAAGGTTCTGCAAATCCTGGAAGAACTTAACATCGGTTGGGAACAT
    ATGCCAACAGGTATCGACGATCTTTCTATCATTCTCCGTTCTCGCCAACTAACTCCCATC
    AAGGAAGAAGAAATCCTGCGTCAGTTGGTTCAAAAGGCTAAAGTAGATCATGCAGAAATC
    GAACACGACCTTTCTATCATTATGATTGTTGGTGAAAAAATGAAGAGCCATATCGGAGTG
    ACTGCTACTGCGACACGCGCTCTATCTGAAAACAAAATCAACATCCAGATGATGTCTCAA
    GGTTCTAGTGAAGTTTCTATTATGTTTGTTGTCAATAAAGACCAAGAGAAAGCAGCAATT
    AAAGCCCTCTACAATGCCTTTTTTGGAGAAAGTAAGGAAGACTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1365

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SP_0413 [new locus tag: SP_RS02045 ]
  • symbol: SP_0413
  • description: aspartate kinase
  • length: 454
  • theoretical pI: 6.07128
  • theoretical MW: 50235
  • GRAVY: -0.161013

⊟Function[edit | edit source]

  • reaction:
    EC 2.7.2.4?  ExPASy
    Aspartate kinase ATP + L-aspartate = ADP + 4-phospho-L-aspartate
  • TIGRFAM:
    Metabolism Amino acid biosynthesis Aspartate family aspartate kinase (TIGR00657; EC 2.7.2.4; HMM-score: 293.5)
    Metabolism Amino acid biosynthesis Aspartate family aspartate kinase, monofunctional class (TIGR00656; EC 2.7.2.4; HMM-score: 246.2)
    and 3 more
    Metabolism Amino acid biosynthesis Aspartate family putative Pyrococcus aspartate kinase subunit (TIGR02078; EC 2.7.2.4; HMM-score: 93.3)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Nucleotide and nucleoside interconversions putative uridylate kinase (TIGR02076; EC 2.7.4.-; HMM-score: 21.6)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Nucleotide and nucleoside interconversions UMP kinase (TIGR02075; EC 2.7.4.22; HMM-score: 14.8)
  • TheSEED  :
    • Aspartokinase (EC 2.7.2.4)
    Amino Acids and Derivatives Lysine, threonine, methionine, and cysteine Lysine Biosynthesis DAP Pathway  Aspartokinase (EC 2.7.2.4)
    and 1 more
    Amino Acids and Derivatives Lysine, threonine, methionine, and cysteine Threonine and Homoserine Biosynthesis  Aspartokinase (EC 2.7.2.4)
  • PFAM:
    no clan defined AA_kinase; Amino acid kinase family (PF00696; HMM-score: 151.4)
    and 5 more
    ACT (CL0070) ACT_7; ACT domain (PF13840; HMM-score: 48.2)
    ACT; ACT domain (PF01842; HMM-score: 33.2)
    no clan defined DsbG_N; Disulfide isomerase DsbG N-terminal (PF18257; HMM-score: 14.5)
    DUF1059; Protein of unknown function (DUF1059) (PF06348; HMM-score: 14.1)
    HetR_C; Heterocyst differentiation regulator C-terminal Hood domain (PF18460; HMM-score: 12)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9843
    • Cytoplasmic Membrane Score: 0.0079
    • Cell wall & surface Score: 0.0004
    • Extracellular Score: 0.0074
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.035627
    • TAT(Tat/SPI): 0.006684
    • LIPO(Sec/SPII): 0.003713
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MKVVKFGGSSLASASQLEKVLNIVKSDSERRFVVVSAPGKRNAEDTKVTDALIKYYRDYVAGNDISKNQSWIIDRYAAMVSELGLKPAVLEKISKSIHALATLPIEENEFLYDTFLAAGENNNAKLIAAYFNQNGIDARYMHPREAGIVVTSEPGHARIIPSSYDKIEELTNTNEVLVIPGFFGVTKENQICTFSRGGSDITGSIIAAGVKADLYENFTDVDGIFAAHPGIIHQPHSIPELTYREMRELAYAGFSVLHDEALLPAYRGKIPLVIKNTNNPDHPGTRIVLKHSNDEFPVVGIAGDSGFVSINMSKYLMNREVGFGRKVLQILEELNIGWEHMPTGIDDLSIILRSRQLTPIKEEEILRQLVQKAKVDHAEIEHDLSIIMIVGEKMKSHIGVTATATRALSENKINIQMMSQGSSEVSIMFVVNKDQEKAAIKALYNAFFGESKED

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site: 394045 [1]

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

  1. ↑ 1.0 1.1 1.2 Indu Warrier, Nikhil Ram-Mohan, Zeyu Zhu, Ariana Hazery, Haley Echlin, Jason Rosch, Michelle M Meyer, Tim van Opijnen
    The Transcriptional landscape of Streptococcus pneumoniae TIGR4 reveals a complex operon architecture and abundant riboregulation critical for growth and virulence.
    PLoS Pathog: 2018, 14(12);e1007461
    [PubMed:30517198] [WorldCat.org] [DOI] (I e)

⊟Relevant publications[edit | edit source]

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