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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae TIGR4
  • locus tag: SP_0474 [new locus tag: SP_RS02340 ]
  • pan locus tag?: PNEUPAN001354000
  • symbol: SP_0474
  • pan gene symbol?: PTS-EII_7
  • synonym:
  • product: PTS system, cellobiose-specific IIC component

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SP_0474 [new locus tag: SP_RS02340 ]
  • symbol: SP_0474
  • product: PTS system, cellobiose-specific IIC component
  • replicon: chromosome
  • strand: +
  • coordinates: 452130..453452
  • length: 1323
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    ATGAACAATATTTTAGCGTTTTTAGAAACAAAAGTCGCTCCGTTTGGTGAAAAAGTTGGC
    AACCAACGGCATTTGAAAGCTATTCGTGAAGGATTTATGATGGCAATGCCTTTGATTTTA
    GTCGGCTCTTTATTTCTTATTCTAATCAGTTGGCCTCAAGAGGCTTTTACAAATTGGCTG
    AATAGTGTTGGATTGCTAAGTATCTTGACAACTATGAATCAGTCAACAGTAGCGATTATC
    TCCTTGGTCGCTTGTTTCGGTATTGCCTACAGGTTGTCGGAAGGATATGGTACAGATGGT
    CCGTCGGCAGGGATCATAGCCTTATCCAGTTTTGTATTGATGGCACCTCGTTTTTCGAGT
    ATGGTTTATGATAAAAATGGGGAGCAGGTCAAGCAGTTATTTGGCGGCGCAATACCATTT
    TCTAGCCTGAATGCATCTTCTTTGTTTATGGCGATTACTATTGGATTGGTTACAGCAGAG
    ATTTATCGTATGTTTATCCAGCGCGGAATTACGATAAAAATGCCAAGTGGTGTCCCAGAT
    GTAGTAAGTAAATCATTTTCAGCTCTTTTATCTGGTTTTACTACTTTTGTTTTGTGGGCT
    TTGGTCTTAAAAGGTCTTGAAGCGGCAGGAGTTGCAGGAGGTCTCAACGGACTCCTAGGT
    GCAATTGTTGGAACACCGCTTAAGTTAATTGCAGGAACGCTTCCAGGTATGATTCTATGT
    GTTATTGTAAACTCATTCTTTTGGTTCTGTGGAGTTAATGGGGGACAAGTTTTAAATGCT
    TTTGTAGACCCAGTTTGGTTACAATTTACTACAGAAAACCAAGAAGCTGTGGCTGCAGGA
    CAAACACTCCAACACATTATTACATTACCGTTTAAAGATTTATTTGTATTTATTGGTGGC
    GGTGGAGCGACTATTGGTCTTGCGATTTGTCTCTTCCTATTTAGTAAGAGTCGTGCGAAT
    AAAACATTAGGTAAGCTAGCTATTATACCGTCTATTTTTAATATCAATACAGCTATTCTA
    TTTACGTTTCCAACAGTTTTAAATCCGATTATGCTGATTCCGTTTATTGCTACTCCTACA
    ATCAATGCCTTGATTACCTATGTATCAATGGCTGTAGGATTAGTACCCTATACAACAGGT
    GTAATCCTTCCGTGGACAATGCCACCGATTATAGGAGGCTTCCTTGCAACAGGGGCTAGT
    TGGCGAGGAGCTCTATTACAAGTTGTTTTGATTTTGGTTTCTGTAGCAATTTATTATCCA
    TTCTTCAAAATTGCAGATAAACGCAATCTTGAAAAAGAAAAAGCTACTGTTGGAGGGAAA
    TAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1323

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SP_0474 [new locus tag: SP_RS02340 ]
  • symbol: SP_0474
  • description: PTS system, cellobiose-specific IIC component
  • length: 440
  • theoretical pI: 9.79081
  • theoretical MW: 47038.7
  • GRAVY: 0.786818

⊟Function[edit | edit source]

  • TIGRFAM:
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids PTS system, cellobiose-specific IIC component (TIGR00359; EC 2.7.1.69; HMM-score: 399.2)
    Signal transduction Signal transduction PTS PTS system, cellobiose-specific IIC component (TIGR00359; EC 2.7.1.69; HMM-score: 399.2)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids PTS system, lactose/cellobiose family IIC component (TIGR00410; EC 2.7.1.69; HMM-score: 399.2)
    Signal transduction Signal transduction PTS PTS system, lactose/cellobiose family IIC component (TIGR00410; EC 2.7.1.69; HMM-score: 399.2)
    and 2 more
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids PTS system, lactose-specific IIC component (TIGR00394; EC 2.7.1.69; HMM-score: 207.4)
    Signal transduction Signal transduction PTS PTS system, lactose-specific IIC component (TIGR00394; EC 2.7.1.69; HMM-score: 207.4)
  • TheSEED  :
    • PTS system, cellobiose-specific IIC component (EC 2.7.1.69)
    Carbohydrates Di- and oligosaccharides Beta-Glucoside Metabolism  PTS system, cellobiose-specific IIC component (EC 2.7.1.69)
  • PFAM:
    PTS_EIIC (CL0493) PTS_EIIC; Phosphotransferase system, EIIC (PF02378; HMM-score: 222.4)
    and 1 more
    no clan defined DUF6223; Family of unknown function (DUF6223) (PF19733; HMM-score: 6.7)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 12
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.006817
    • TAT(Tat/SPI): 0.000237
    • LIPO(Sec/SPII): 0.002644
  • predicted transmembrane helices (TMHMM): 10

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MNNILAFLETKVAPFGEKVGNQRHLKAIREGFMMAMPLILVGSLFLILISWPQEAFTNWLNSVGLLSILTTMNQSTVAIISLVACFGIAYRLSEGYGTDGPSAGIIALSSFVLMAPRFSSMVYDKNGEQVKQLFGGAIPFSSLNASSLFMAITIGLVTAEIYRMFIQRGITIKMPSGVPDVVSKSFSALLSGFTTFVLWALVLKGLEAAGVAGGLNGLLGAIVGTPLKLIAGTLPGMILCVIVNSFFWFCGVNGGQVLNAFVDPVWLQFTTENQEAVAAGQTLQHIITLPFKDLFVFIGGGGATIGLAICLFLFSKSRANKTLGKLAIIPSIFNINTAILFTFPTVLNPIMLIPFIATPTINALITYVSMAVGLVPYTTGVILPWTMPPIIGGFLATGASWRGALLQVVLILVSVAIYYPFFKIADKRNLEKEKATVGGK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulators: XylR* (repression) regulon, CcpA regulon
    XylR*(TF)important in Cellobiose utilization; RegPrecise 
    CcpA(TF)important in Global catabolite repression; RegPrecise 

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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