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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae TIGR4
  • locus tag: SP_0674 [new locus tag: SP_RS03310 ]
  • pan locus tag?: PNEUPAN001590000
  • symbol: SP_0674
  • pan gene symbol?: rnz
  • synonym:
  • product: metallo-beta-lactamase superfamily protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SP_0674 [new locus tag: SP_RS03310 ]
  • symbol: SP_0674
  • product: metallo-beta-lactamase superfamily protein
  • replicon: chromosome
  • strand: +
  • coordinates: 649056..649985
  • length: 930
  • essential: yes [1] DEG

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    ATGGATATTCAATTTTTAGGAACGGGGGCTGGTCAGCCCTCTAAAGCCCGCAACGTTTCA
    AGTCTCGCCCTGAAACTTTTGGATGAGATTAACGAAGTTTGGCTCTTTGACTGTGGAGAA
    GGTACGCAAAATCGCATTCTGGAAACCACAATTCGACCACGTAAGGTCAGCAAAATCTTT
    ATTACCCATCTGCATGGAGACCACATTTTTGGTTTGCCAGGTTTCCTTTCTAGCCGTGCC
    TTTCAGGCCAATGAAGAGCAGACAGATTTGGAAATCTACGGACCTCAAGGAATCAAGTCA
    TTTGTCTTAACCAGCCTTCGTGTGTCAGGTTCTCGTCTGCCCTACCGCATTCATTTCCAT
    GAGTTTGACCAAGATTCTCTGGGTAAAATTCTTGAAACCGATAAATTCACTGTGTATGCA
    GAGGAGCTGGACCACACTATTTTCTGTGTTGGCTATCGTGTCATGCAAAAGGATCTAGAA
    GGGACGCTGGATGCTGAAAAACTCAAGGCTGCTGGTGTTCCGTTCGGCCCGCTTTTTGGT
    AAAATCAAAAACGGCCAGGATCTTGTTTTGGAAGACGGAACTGAAATCAAGGCAGCAGAC
    TATATCTCAGCGCCACGTCCAGGTAAGATTATCACTATTTTAGGAGACACTCGAAAAACG
    GGTGCCAGTGTGCGTCTGGCTGTCAATGCAGATGTCCTAGTTCATGAGTCCACTTATGGC
    AAGGGTGATGAAAAAATTGCTCGTAACCATGGTCACTCAACTAATATGCAAGCTGCACAA
    GTAGCGGTAGAAGCAGGTGCCAAACGCCTCCTACTCAACCATATCAGTGCCCGTTTCCTC
    TCAAAAGATATTAGCAAACTCAAGAAAGACGCTGCCACAATTTTTGAAAATGTCCATGTG
    GTCAAAGACTTGGAAGAAGTGGAAATCTAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    930

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SP_0674 [new locus tag: SP_RS03310 ]
  • symbol: SP_0674
  • description: metallo-beta-lactamase superfamily protein
  • length: 309
  • theoretical pI: 6.74731
  • theoretical MW: 34139.7
  • GRAVY: -0.221359

⊟Function[edit | edit source]

  • TIGRFAM:
    Genetic information processing Transcription RNA processing ribonuclease Z (TIGR02651; EC 3.1.26.11; HMM-score: 353.6)
    Genetic information processing Transcription RNA processing ribonuclease BN (TIGR02649; EC 3.1.-.-; HMM-score: 285.5)
    and 5 more
    Genetic information processing Transcription RNA processing ribonuclease Z, Thermotoga type (TIGR02650; EC 3.1.26.11; HMM-score: 42.9)
    phosphonate metabolism protein PhnP (TIGR03307; HMM-score: 18.7)
    Unknown function Enzymes of unknown specificity quinoprotein relay system zinc metallohydrolase 1 (TIGR04558; HMM-score: 14.8)
    Unknown function Enzymes of unknown specificity quinoprotein relay system zinc metallohydrolase 2 (TIGR04559; EC 3.-.-.-; HMM-score: 13.8)
    Cellular processes Cellular processes Detoxification hydroxyacylglutathione hydrolase (TIGR03413; EC 3.1.2.6; HMM-score: 13.7)
  • TheSEED  :
    • Ribonuclease Z (EC 3.1.26.11)
    RNA Metabolism RNA processing and modification tRNA processing  Ribonuclease Z (EC 3.1.26.11)
  • PFAM:
    Metallo-HOrase (CL0381) Lactamase_B_2; Beta-lactamase superfamily domain (PF12706; HMM-score: 53)
    and 2 more
    Lactamase_B; Metallo-beta-lactamase superfamily (PF00753; HMM-score: 36.4)
    Lactamase_B_4; tRNase Z endonuclease (PF13691; HMM-score: 23.8)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.985
    • Cytoplasmic Membrane Score: 0.0016
    • Cell wall & surface Score: 0.0002
    • Extracellular Score: 0.0132
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.003474
    • TAT(Tat/SPI): 0.00076
    • LIPO(Sec/SPII): 0.00137
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MDIQFLGTGAGQPSKARNVSSLALKLLDEINEVWLFDCGEGTQNRILETTIRPRKVSKIFITHLHGDHIFGLPGFLSSRAFQANEEQTDLEIYGPQGIKSFVLTSLRVSGSRLPYRIHFHEFDQDSLGKILETDKFTVYAEELDHTIFCVGYRVMQKDLEGTLDAEKLKAAGVPFGPLFGKIKNGQDLVLEDGTEIKAADYISAPRPGKIITILGDTRKTGASVRLAVNADVLVHESTYGKGDEKIARNHGHSTNMQAAQVAVEAGAKRLLLNHISARFLSKDISKLKKDAATIFENVHVVKDLEEVEI

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

  1. ↑ Jane A Thanassi, Sandra L Hartman-Neumann, Thomas J Dougherty, Brian A Dougherty, Michael J Pucci
    Identification of 113 conserved essential genes using a high-throughput gene disruption system in Streptococcus pneumoniae.
    Nucleic Acids Res: 2002, 30(14);3152-62
    [PubMed:12136097] [WorldCat.org] [DOI] (I p)    Tim van Opijnen, Andrew Camilli
    A fine scale phenotype-genotype virulence map of a bacterial pathogen.
    Genome Res: 2012, 22(12);2541-51
    [PubMed:22826510] [WorldCat.org] [DOI] (I p)

⊟Relevant publications[edit | edit source]

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