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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae TIGR4
  • locus tag: SP_0765 [new locus tag: SP_RS03735 ]
  • pan locus tag?: PNEUPAN001704000
  • symbol: holA
  • pan gene symbol?: holA
  • synonym:
  • product: DNA polymerase III, delta subunit

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SP_0765 [new locus tag: SP_RS03735 ]
  • symbol: holA
  • product: DNA polymerase III, delta subunit
  • replicon: chromosome
  • strand: +
  • coordinates: 724170..725207
  • length: 1038
  • essential: yes [1]

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    ATGCTAGCCATTGAAGAAAGTCAGAAGTTGACTTTATCAAATTTACCGAGCCTGAGCCTA
    TTTACAGGGACAGATCAGGGTCAGTTTGAAGTGATGAAGAGTCAAATGTTGAAACAGATT
    GGGTATGATTCTGCTGACCTCAACTTTGCCTACTTTGATATGAAAGAAGTAGTTTACAAG
    GATGTGGAACTGGAGTTGGTCAGCCTTCCTTTCTTTGCGGATGAGAAAATCGTGATATTA
    GATTATTTTATGGATATCACGACTGCTAAGAAACGCTTTTTGACAGATGATGAGCTTAAG
    TCATTTGAGGAATACCTTGACAATCCTTCTCCAACAACCAAGTTGATAATCTTTGCAGAA
    GGAAAGCTGGATAGCAAAAGACGGTTAGTCAAATTACTTAAGCGTGATGCCAAGGCCTTC
    GATGCAGTAGAAGTAAAAGAACAAGAATTGCGCCAGTACTTCCAAAAGTGGAGTCAGAAA
    CAAGGTCTGCAGTTTACCAATCATTCTTTTGAAAATCTCCTCATCAAGTCGGGGTTTCAA
    TTTAGCGAAATCCAGAAAAATCTTCTCTTTTTACAGTCCTATAAGGCGAATTCTGTTATT
    GAGGAAGAGGATATTGTTAACGCAATTCCCAAGACCTTGCAGGACAATATTTTTGATTTA
    ACTCAGTTTATTCTGACTAAAAAGATGGATCAGGCGCGCGATTTGGTGAGAGACTTGACC
    TTGCAAGGGGAAGATGAAATCAAACTGATTGCAGTCATGCTGGGACAATTTCGGACTTTT
    ACTCAGGTGAAGATTTTGGCGGAGTCTGGCCAAACAGAATCGCAGATTGCAAGTAGTTTA
    GGTAGTTATCTGGGACGTAACCCAAATCCTTATCAAATCAAGTTTGCATTAAGAGATTCG
    AGAGGACTTTCTTTGAGCTTTTTGAAGCAAGCTATTTCCTATTTGATTGAGACAGACTAT
    CAGATTAAGACAGGTCTTTATGAAAAAGGTTTCCTTTTTGAAAAGGCACTCTTACAGATT
    GCTAGTCAGGTCAATTGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1038

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SP_0765 [new locus tag: SP_RS03735 ]
  • symbol: HolA
  • description: DNA polymerase III, delta subunit
  • length: 345
  • theoretical pI: 4.87227
  • theoretical MW: 39742.3
  • GRAVY: -0.248406

⊟Function[edit | edit source]

  • TIGRFAM:
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA polymerase III, delta subunit (TIGR01128; EC 2.7.7.7; HMM-score: 290.1)
    and 1 more
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA polymerase III, subunit gamma and tau (TIGR02397; EC 2.7.7.7; HMM-score: 20.3)
  • TheSEED  :
    • DNA polymerase III delta subunit (EC 2.7.7.7)
    DNA Metabolism DNA replication DNA-replication  DNA polymerase III delta subunit (EC 2.7.7.7)
  • PFAM:
    P-loop_NTPase (CL0023) DNA_pol3_delta; DNA polymerase III, delta subunit (PF06144; HMM-score: 158.3)
    and 1 more
    post-AAA (CL0604) DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III (PF12169; HMM-score: 16.5)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 1.78
    • Cytoplasmic Membrane Score: 8.16
    • Cellwall Score: 0.06
    • Extracellular Score: 0.01
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9509
    • Cytoplasmic Membrane Score: 0.0255
    • Cell wall & surface Score: 0.0032
    • Extracellular Score: 0.0204
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.004252
    • TAT(Tat/SPI): 0.000628
    • LIPO(Sec/SPII): 0.001885
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MLAIEESQKLTLSNLPSLSLFTGTDQGQFEVMKSQMLKQIGYDSADLNFAYFDMKEVVYKDVELELVSLPFFADEKIVILDYFMDITTAKKRFLTDDELKSFEEYLDNPSPTTKLIIFAEGKLDSKRRLVKLLKRDAKAFDAVEVKEQELRQYFQKWSQKQGLQFTNHSFENLLIKSGFQFSEIQKNLLFLQSYKANSVIEEEDIVNAIPKTLQDNIFDLTQFILTKKMDQARDLVRDLTLQGEDEIKLIAVMLGQFRTFTQVKILAESGQTESQIASSLGSYLGRNPNPYQIKFALRDSRGLSLSFLKQAISYLIETDYQIKTGLYEKGFLFEKALLQIASQVN

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

  1. ↑ Tim van Opijnen, Andrew Camilli
    A fine scale phenotype-genotype virulence map of a bacterial pathogen.
    Genome Res: 2012, 22(12);2541-51
    [PubMed:22826510] [WorldCat.org] [DOI] (I p)
  2. ↑ 2.0 2.1 Indu Warrier, Nikhil Ram-Mohan, Zeyu Zhu, Ariana Hazery, Haley Echlin, Jason Rosch, Michelle M Meyer, Tim van Opijnen
    The Transcriptional landscape of Streptococcus pneumoniae TIGR4 reveals a complex operon architecture and abundant riboregulation critical for growth and virulence.
    PLoS Pathog: 2018, 14(12);e1007461
    [PubMed:30517198] [WorldCat.org] [DOI] (I e)

⊟Relevant publications[edit | edit source]

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