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PangenomeTIGR4
serotype 4
D39serotype 2
D39Vserotype 2
Hungary19A-6serotype 19A
EF3030serotype 19F
670-6Bserotype 6B
6A-10serotype 6A
70585serotype 5
A026serotype 19F
A66serotype 3
AP200serotype 11A
ASP0581serotype 12F
ATCC 49619serotype 19F
ATCC 700669serotype 23F
BVJ1JLserotype 1
CGSP14serotype 14
G54serotype 19F
HU-OHserotype 3
Hu15serotype 19A
Hu17serotype 19A
INV104serotype 1
INV200serotype 14
JJAserotype 14
MDRSPN001serotype 19F
NCTC7466serotype 2
NU83127serotype 4
OXC141serotype 3
P1031serotype 1
R6serotype 2
SP49serotype 19A
SPN032672serotype 1
SPN034156serotype 3
SPN034183serotype 3
SPN994038serotype 3
SPN994039serotype 3
SPNA45serotype 3
ST556serotype 19F
TCH8431/19Aserotype 19A
Taiwan19F-14serotype 19F
Xen35serotype 4
gamPNI0373serotype 1
NCBI: 31-JAN-2014
⊟Summary[edit | edit source]
- organism: Streptococcus pneumoniae TIGR4
- locus tag: SP_0839 [new locus tag: SP_RS04105 ]
- pan locus tag?: PNEUPAN001810000
- symbol: coaA
- pan gene symbol?: coaA
- synonym:
- product: pantothenate kinase
⊟Genome View[edit | edit source]
⊟Gene[edit | edit source]
⊟General[edit | edit source]
- type: CDS
- locus tag: SP_0839 [new locus tag: SP_RS04105 ]
- symbol: coaA
- product: pantothenate kinase
- replicon: chromosome
- strand: -
- coordinates: 786690..787610
- length: 921
- essential: yes [1]
⊟Accession numbers[edit | edit source]
- Location: AE005672 (786690..787610) NCBI
- BioCyc: see SP_RS04105
- MicrobesOnline: 116329 MicrobesOnline
- PneumoBrowse for strain D39V: SPV_0733 PneumoBrowse
⊟Phenotype[edit | edit source]
Share your knowledge and add information here. [edit]
⊟DNA sequence[edit | edit source]
- 1
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901ATGACCAACGAATTTTTACATTTTGAAAAAATCAGCCGCCAGACTTGGCAATCTTTACAT
CGAAAGACAACACCTCCTTTGACAGAAGAAGAATTGGAATCTATCAAGAGTTTTAATGAC
CAAATCAGTCTCCAAGACGTTACAGATATCTATCTCCCCTTGGCTCATTTGATTCAGATT
TACAAGCGAACTAAGGAAGATTTAGCCTTTTCAAAAGGAATTTTCCTCCAACGTGAAAGT
AAATCTCAACCTTTTATTATTGGGGTTTCTGGGAGTGTTGCCGTTGGAAAATCCACAACC
AGTCGCCTACTTCAAATCCTACTGTCCCGTACGTTTACAGATGCTACGGTTGAGTTGGTT
ACAACTGATGGTTTTCTCTATCCCAATCAAACCTTGATTGAGCAGGGGATTTTAAATCGT
AAAGGATTTCCTGAAAGCTATGATATGGAAGCTCTTCTCAACTTCTTGGACCGCATCAAA
AATGGACAAGATGTAGATATTCCTGTCTATTCTCATGAAGTTTACGACATCGTACCCGAA
GAGAAACAAAGTGTCAAAGCTGCTGATTTTGTAATTGTTGAGGGAATCAATGTCTTTCAA
AATCCACAAAACGATCGTCTCTATATCACTGACTTCTTTGACTTTTCCATCTATGTAGAT
GCTGGAGTGGATGATATTGAAAGTTGGTATCTGGACCGTTTCTTGAAAATGCTGAGTCTA
GCCCAAAACGACCCTGATAGCTACTATTATCGTTTTACTCAGATGCCGATTGGGGAAGTG
GAGTCCTTTGCCCATCAGGTCTGGATCAGTATCAATCTCACAAATCTGCAAAATTATATT
GAACCAACCAGAAATCGTGCAGAAGTGATTCTTCATAAAAGCAAGAACCATGAAATCGAT
GAAATTTACTTAAAAAAGTAA60
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921
⊟Protein[edit | edit source]
⊟General[edit | edit source]
- locus tag: SP_0839 [new locus tag: SP_RS04105 ]
- symbol: CoaA
- description: pantothenate kinase
- length: 306
- theoretical pI: 4.67306
- theoretical MW: 35555.9
- GRAVY: -0.337582
⊟Function[edit | edit source]
- reaction: EC 2.7.1.33? ExPASyPantothenate kinase ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate
- TIGRFAM: Biosynthesis of cofactors, prosthetic groups, and carriers Pantothenate and coenzyme A pantothenate kinase (TIGR00554; EC 2.7.1.33; HMM-score: 329.5)and 1 morePurines, pyrimidines, nucleosides, and nucleotides Salvage of nucleosides and nucleotides uridine kinase (TIGR00235; EC 2.7.1.48; HMM-score: 62.7)
- TheSEED :
- Pantothenate kinase (EC 2.7.1.33)
- PFAM: P-loop_NTPase (CL0023) PRK; Phosphoribulokinase / Uridine kinase family (PF00485; HMM-score: 55.9)and 3 moreno clan defined ER; Enhancer of rudimentary (PF01133; HMM-score: 13.6)DnaB; DnaB-like helicase N terminal domain (PF00772; HMM-score: 12.9)P-loop_NTPase (CL0023) CoaE; Dephospho-CoA kinase (PF01121; HMM-score: 12.4)
⊟Structure, modifications & cofactors[edit | edit source]
- domains:
- modifications:
- cofactors:
- effectors:
⊟Localization[edit | edit source]
- PSORTb: Cytoplasmic
- Cytoplasmic Score: 9.97
- Cytoplasmic Membrane Score: 0
- Cellwall Score: 0.01
- Extracellular Score: 0.02
- Internal Helices: 0
- SignalP: no predicted signal peptide
- SP(Sec/SPI): 0.001666
- TAT(Tat/SPI): 0.000238
- LIPO(Sec/SPII): 0.000398
- predicted transmembrane helices (TMHMM): 0
⊟Accession numbers[edit | edit source]
⊟Protein sequence[edit | edit source]
- MTNEFLHFEKISRQTWQSLHRKTTPPLTEEELESIKSFNDQISLQDVTDIYLPLAHLIQIYKRTKEDLAFSKGIFLQRESKSQPFIIGVSGSVAVGKSTTSRLLQILLSRTFTDATVELVTTDGFLYPNQTLIEQGILNRKGFPESYDMEALLNFLDRIKNGQDVDIPVYSHEVYDIVPEEKQSVKAADFVIVEGINVFQNPQNDRLYITDFFDFSIYVDAGVDDIESWYLDRFLKMLSLAQNDPDSYYYRFTQMPIGEVESFAHQVWISINLTNLQNYIEPTRNRAEVILHKSKNHEIDEIYLKK
⊟Experimental data[edit | edit source]
- protein localization:
- interaction partners:
⊟Expression & Regulation[edit | edit source]
⊟Operon[edit | edit source]
- MicrobesOnline: SP_0837 < rpsT < coaA
⊟Regulation[edit | edit source]
- regulator: CcpA regulon
CcpA (TF) important in Global catabolite repression; RegPrecise
⊟Expression data[edit | edit source]
- PneumoExpress for strain D39V: SPV_0733 PneumoExpress
⊟Biological Material[edit | edit source]
⊟Mutants[edit | edit source]
⊟Expression vector[edit | edit source]
⊟lacZ fusion[edit | edit source]
⊟GFP fusion[edit | edit source]
⊟two-hybrid system[edit | edit source]
⊟FLAG-tag construct[edit | edit source]
⊟Antibody[edit | edit source]
⊟Other Information[edit | edit source]
You are kindly invited to share additional interesting facts.
⊟Literature[edit | edit source]
⊟References[edit | edit source]
- ↑ Tim van Opijnen, Andrew Camilli
A fine scale phenotype-genotype virulence map of a bacterial pathogen.
Genome Res: 2012, 22(12);2541-51
[PubMed:22826510] [WorldCat.org] [DOI] (I p)