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TIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae TIGR4
  • locus tag: SP_1149
  • pan locus tag?:
  • symbol: SP_1149
  • pan gene symbol?: —
  • synonym:
  • product: IS630-Spn1, transposase Orf1

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SP_1149
  • symbol: SP_1149
  • product: IS630-Spn1, transposase Orf1
  • replicon: chromosome
  • strand: -
  • coordinates: 1074433..1074849
  • length: 417
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: AE005672 (1074433..1074849) NCBI
  • BioCyc:
  • MicrobesOnline: 116617 MicrobesOnline
  • PneumoBrowse for strain D39V:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    ATGTGGTATAATCTTCTTATGGCATATTCAATAGATTTTCGTAAAAAAGTTCTCTCTTAT
    TGTGAGCGAACAGGTAGTATAACAGAAGCATCACACGTTTTCCAAATCTCACGTAATACC
    ATTTATGGCTGGTTAAAGCTAAAAGAGAAAACAGGAGAGCTAAACCACCAAGTAAAAGGA
    ACAAAACCAAGAAAAGTTGATAGAGATAGACTTAAAAACTATCTTACTGACAATCCAGAT
    GCTTATTTGACTGAAATAGCTTCTGACTTTGGCTGTCATCCAACTACCATCCACTATGCG
    CTCAAAGCTATGGGCTACACTCGAAAAAAGAACCACACCTACTATGAACAAGACCCAGAA
    AAAGTAGCCTTATTTCTTAAGAATTTTAATAGTTTAAAGCACCTAACACCTGTTTAG
    60
    120
    180
    240
    300
    360
    417

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SP_1149
  • symbol: SP_1149
  • description: IS630-Spn1, transposase Orf1
  • length: 138
  • theoretical pI: 9.85146
  • theoretical MW: 16209.5
  • GRAVY: -0.675362

⊟Function[edit | edit source]

  • TIGRFAM:
  • TheSEED  :
    • Mobile element protein
  • PFAM:
    HTH (CL0123) HTH_Tnp_IS630; Transposase (PF01710; HMM-score: 104.3)
    and 16 more
    HTH_28; Helix-turn-helix domain (PF13518; HMM-score: 36.4)
    HTH_29; Winged helix-turn helix (PF13551; HMM-score: 25.9)
    HTH_23; Homeodomain-like domain (PF13384; HMM-score: 25)
    HTH_17; Helix-turn-helix domain (PF12728; HMM-score: 21.8)
    HTH_30; PucR C-terminal helix-turn-helix domain (PF13556; HMM-score: 19.8)
    HTH_33; Winged helix-turn helix (PF13592; HMM-score: 19.8)
    HTH_Tnp_ISL3; Helix-turn-helix domain of transposase family ISL3 (PF13542; HMM-score: 19.3)
    CENP-B_N; CENP-B N-terminal DNA-binding domain (PF04218; HMM-score: 17.2)
    HTH_Tnp_1_2; Helix-turn-helix of insertion element transposase (PF13022; HMM-score: 14.8)
    FeoC; FeoC like transcriptional regulator (PF09012; HMM-score: 14.6)
    HTH_38; Helix-turn-helix domain (PF13936; HMM-score: 14.3)
    Terminase_5; Putative ATPase subunit of terminase (gpP-like) (PF06056; HMM-score: 13.6)
    HTH_8; Bacterial regulatory protein, Fis family (PF02954; HMM-score: 13.2)
    HTH_PafC; PafC helix-turn-helix domain (PF19187; HMM-score: 12.6)
    HTH_Tnp_4; Helix-turn-helix of DDE superfamily endonuclease (PF13613; HMM-score: 12.1)
    HTH_IclR; IclR helix-turn-helix domain (PF09339; HMM-score: 11.5)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: unknown (no significant prediction)
    • Cytoplasmic Score: 2.5
    • Cytoplasmic Membrane Score: 2.5
    • Cellwall Score: 2.5
    • Extracellular Score: 2.5
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.8815
    • Cytoplasmic Membrane Score: 0.0004
    • Cell wall & surface Score: 0.0004
    • Extracellular Score: 0.1178
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.011372
    • TAT(Tat/SPI): 0.000462
    • LIPO(Sec/SPII): 0.004648
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MWYNLLMAYSIDFRKKVLSYCERTGSITEASHVFQISRNTIYGWLKLKEKTGELNHQVKGTKPRKVDRDRLKNYLTDNPDAYLTEIASDFGCHPTTIHYALKAMGYTRKKNHTYYEQDPEKVALFLKNFNSLKHLTPV

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

  • PneumoExpress for strain D39V:

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

  1. ↑ Indu Warrier, Nikhil Ram-Mohan, Zeyu Zhu, Ariana Hazery, Haley Echlin, Jason Rosch, Michelle M Meyer, Tim van Opijnen
    The Transcriptional landscape of Streptococcus pneumoniae TIGR4 reveals a complex operon architecture and abundant riboregulation critical for growth and virulence.
    PLoS Pathog: 2018, 14(12);e1007461
    [PubMed:30517198] [WorldCat.org] [DOI] (I e)

⊟Relevant publications[edit | edit source]

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