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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae TIGR4
  • locus tag: SP_1162 [new locus tag: SP_RS05730 ]
  • pan locus tag?: PNEUPAN002387000
  • symbol: SP_1162
  • pan gene symbol?: acoC
  • synonym:
  • product: putative acetoin dehydrogenase complex, E2 component, dihydrolipoamide acetyltransferase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SP_1162 [new locus tag: SP_RS05730 ]
  • symbol: SP_1162
  • product: putative acetoin dehydrogenase complex, E2 component, dihydrolipoamide acetyltransferase
  • replicon: chromosome
  • strand: -
  • coordinates: 1098046..1099089
  • length: 1044
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    ATGGCTGATGACAAGCTAAGAGCGACTCCTGCAGCTAGAAAGTTAGCGGATGATTTAGGG
    ATAAACCTCTACGACGTTTCTGGCTCAGGTGCAAACGGTCGTGTCCACAAAGAAGACGTG
    GAAACTTATAAAGACACAAACGTGGTTCGCATTTCGCCACTTGCAAAACGAATTGCCCTC
    GAACATAACATTGCTTGGCAGGAAATCCAAGGAACCGGTCATCGTGGTAAAATCATGAAG
    AAGGATGTTTTGGCCCTGCTTCCTGAAAATATCGAAAACGATAGCATCAAATCTCCTGCT
    CAGATTGAAAAAGTGGAAGAAGTCCCTGATAACGTAACACCATATGGTAAAATCGAGCGT
    ATTCCAATGACACCAATGCGTAAGGTTATTGCCCAACGCATGGTTGAATCTTACTTGACT
    GCGCCAACCTTCACCCTCAACTATGAAGTTGATATGACTGAAATGTTGGCTCTTCGTAAG
    AAGGTTCTTGAGCCAATCATGGAAGCAACTGGGAAGAAGACTACTGTAACAGACCTTCTT
    TCGCTTGCAGTTGTTAAGACTCTTATGAAACACCCATACATCAACGCTTCATTGACAGAA
    GATGGCAAGACTATTATCACTCACAACTATGTCAATCTTGCCATGGCAGTTGGGATGGAT
    AATGGATTGATGACACCTGTTGTTTACAATGCTGAGAAGATGAGTCTTTCAGAACTGGTT
    GTAGCCTTTAAGGATGTTATTGGCCGTACCTTGGATGGTAAATTGGCTCCAAGTGAGTTA
    CAAAATTCAACATTCACAATCAGTAATTTGGGAATGTTTGGTGTTCAGTCCTTTGGTCCG
    ATTATTAACCAACCCAACTCAGCTATCCTTGGTGTCAGTTCGACAATCGAGAAGCCAGTT
    GTCGTCAATGGTGAAATTGTGATTCGCCCAATCATGAGTTTAGGATTAACCATTGACCAC
    CGTGTCGTAGATGGTATGGCTGGTGCTAAGTTTATGAAGGACTTGAAAGAGTTGATTGAA
    ACGCCAATCTCAATGTTAATTTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1044

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SP_1162 [new locus tag: SP_RS05730 ]
  • symbol: SP_1162
  • description: putative acetoin dehydrogenase complex, E2 component, dihydrolipoamide acetyltransferase
  • length: 347
  • theoretical pI: 6.53402
  • theoretical MW: 38098.2
  • GRAVY: -0.0377522

⊟Function[edit | edit source]

  • reaction:
    EC 2.3.1.12?  ExPASy
    Dihydrolipoyllysine-residue acetyltransferase Acetyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-acetyldihydrolipoyl)lysine
  • TIGRFAM:
    Metabolism Energy metabolism Pyruvate dehydrogenase pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase (TIGR01349; EC 2.3.1.12; HMM-score: 292.2)
    Metabolism Energy metabolism Pyruvate dehydrogenase dihydrolipoyllysine-residue acetyltransferase (TIGR01348; EC 2.3.1.12; HMM-score: 243.2)
    Metabolism Energy metabolism TCA cycle dihydrolipoyllysine-residue succinyltransferase, E2 component of oxoglutarate dehydrogenase (succinyl-transferring) complex (TIGR01347; EC 2.3.1.61; HMM-score: 237.4)
    and 1 more
    2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase (TIGR02927; EC 2.3.1.61; HMM-score: 222.9)
  • TheSEED  :
    • Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex (EC 2.3.1.12)
    Carbohydrates Central carbohydrate metabolism Dehydrogenase complexes  Dihydrolipoamide acetyltransferase component (E2) of acetoin dehydrogenase complex (EC 2.3.1.-)
    and 2 more
    Carbohydrates Fermentation Acetoin, butanediol metabolism  Dihydrolipoamide acetyltransferase component (E2) of acetoin dehydrogenase complex (EC 2.3.1.-)
    Cofactors, Vitamins, Prosthetic Groups, Pigments Lipoic acid Lipoic acid metabolism  Dihydrolipoamide acetyltransferase component (E2) of acetoin dehydrogenase complex (EC 2.3.1.-)
  • PFAM:
    CoA-acyltrans (CL0149) 2-oxoacid_dh; 2-oxoacid dehydrogenases acyltransferase (catalytic domain) (PF00198; HMM-score: 276.4)
    and 1 more
    no clan defined E3_binding; e3 binding domain (PF02817; HMM-score: 92.8)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9905
    • Cytoplasmic Membrane Score: 0.0012
    • Cell wall & surface Score: 0.0001
    • Extracellular Score: 0.0083
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.008271
    • TAT(Tat/SPI): 0.000911
    • LIPO(Sec/SPII): 0.002103
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MADDKLRATPAARKLADDLGINLYDVSGSGANGRVHKEDVETYKDTNVVRISPLAKRIALEHNIAWQEIQGTGHRGKIMKKDVLALLPENIENDSIKSPAQIEKVEEVPDNVTPYGKIERIPMTPMRKVIAQRMVESYLTAPTFTLNYEVDMTEMLALRKKVLEPIMEATGKKTTVTDLLSLAVVKTLMKHPYINASLTEDGKTIITHNYVNLAMAVGMDNGLMTPVVYNAEKMSLSELVVAFKDVIGRTLDGKLAPSELQNSTFTISNLGMFGVQSFGPIINQPNSAILGVSSTIEKPVVVNGEIVIRPIMSLGLTIDHRVVDGMAGAKFMKDLKELIETPISMLI

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

  1. ↑ 1.0 1.1 Indu Warrier, Nikhil Ram-Mohan, Zeyu Zhu, Ariana Hazery, Haley Echlin, Jason Rosch, Michelle M Meyer, Tim van Opijnen
    The Transcriptional landscape of Streptococcus pneumoniae TIGR4 reveals a complex operon architecture and abundant riboregulation critical for growth and virulence.
    PLoS Pathog: 2018, 14(12);e1007461
    [PubMed:30517198] [WorldCat.org] [DOI] (I e)

⊟Relevant publications[edit | edit source]

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