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PangenomeTIGR4
serotype 4
D39serotype 2
D39Vserotype 2
Hungary19A-6serotype 19A
EF3030serotype 19F
670-6Bserotype 6B
6A-10serotype 6A
70585serotype 5
A026serotype 19F
A66serotype 3
AP200serotype 11A
ASP0581serotype 12F
ATCC 49619serotype 19F
ATCC 700669serotype 23F
BVJ1JLserotype 1
CGSP14serotype 14
G54serotype 19F
HU-OHserotype 3
Hu15serotype 19A
Hu17serotype 19A
INV104serotype 1
INV200serotype 14
JJAserotype 14
MDRSPN001serotype 19F
NCTC7466serotype 2
NU83127serotype 4
OXC141serotype 3
P1031serotype 1
R6serotype 2
SP49serotype 19A
SPN032672serotype 1
SPN034156serotype 3
SPN034183serotype 3
SPN994038serotype 3
SPN994039serotype 3
SPNA45serotype 3
ST556serotype 19F
TCH8431/19Aserotype 19A
Taiwan19F-14serotype 19F
Xen35serotype 4
gamPNI0373serotype 1
NCBI: 31-JAN-2014
⊟Summary[edit | edit source]
- organism: Streptococcus pneumoniae TIGR4
- locus tag: SP_1571 [new locus tag: SP_RS07745 ]
- pan locus tag?: PNEUPAN002955000
- symbol: folA
- pan gene symbol?: folA
- synonym:
- product: dihydrofolate reductase
⊟Genome View[edit | edit source]
⊟Gene[edit | edit source]
⊟General[edit | edit source]
- type: CDS
- locus tag: SP_1571 [new locus tag: SP_RS07745 ]
- symbol: folA
- product: dihydrofolate reductase
- replicon: chromosome
- strand: -
- coordinates: 1477417..1477923
- length: 507
- essential: yes [1]
⊟Accession numbers[edit | edit source]
- Location: AE005672 (1477417..1477923) NCBI
- BioCyc: see SP_RS07745
- MicrobesOnline: 117017 MicrobesOnline
- PneumoBrowse for strain D39V: SPV_1401 PneumoBrowse
⊟Phenotype[edit | edit source]
Share your knowledge and add information here. [edit]
⊟DNA sequence[edit | edit source]
- 1
61
121
181
241
301
361
421
481ATGACTAAGAAAATCGTAGCTATTTGGGCCCAGGATGAAGAGGGTGTGATTGGTAAGGAA
AATCGTCTGCCTTGGCATTTGCCAGCAGAATTGCAGCACTTTAAAGAAACAACTCTGAAT
CATGCTATCTTGATGGGGCGTGTGACCTTTGATGGGATGGGGCGTCGCTTGCTTCCAAAA
CGGGAAACCTTGATTTTGACGCGTAATCCGGAAGAAAAGATAGATGGGGTTGCTACTTTT
CAGGACGTCCAGTCTGTTCTTGACTGGTATCAGGCTCAAGAAAAGAATCTCTACATTATC
GGTGGGAAGCAAATTTTTCAGGCTTTTGAACCTTACCTTGATGAAGTGATTGTCACTCAC
ATTCATGCTCGGGTGGAAGGAGATACCTATTTCCCTGAAGAACTTGACTTGTCTCTTTTT
GAGACAGTTTCAAGCAAATTTTACGCCAAAGATGAGAAGAATCCTTATGATTTTACCATC
CAATACCGCAAGAGAAAGGAAGTCTAA60
120
180
240
300
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420
480
507
⊟Protein[edit | edit source]
⊟General[edit | edit source]
- locus tag: SP_1571 [new locus tag: SP_RS07745 ]
- symbol: FolA
- description: dihydrofolate reductase
- length: 168
- theoretical pI: 5.66077
- theoretical MW: 19703.3
- GRAVY: -0.499405
⊟Function[edit | edit source]
- reaction: EC 1.5.1.3? ExPASyDihydrofolate reductase 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH
- TIGRFAM:
- TheSEED :
- Dihydrofolate reductase (EC 1.5.1.3)
- PFAM: DHFred (CL0387) DHFR_1; Dihydrofolate reductase (PF00186; HMM-score: 188.7)
⊟Structure, modifications & cofactors[edit | edit source]
- domains:
- modifications:
- cofactors:
- effectors:
⊟Localization[edit | edit source]
- PSORTb: Cytoplasmic
- Cytoplasmic Score: 7.5
- Cytoplasmic Membrane Score: 1.15
- Cellwall Score: 0.62
- Extracellular Score: 0.73
- Internal Helices: 0
- SignalP: no predicted signal peptide
- SP(Sec/SPI): 0.003345
- TAT(Tat/SPI): 0.00017
- LIPO(Sec/SPII): 0.000641
- predicted transmembrane helices (TMHMM): 0
⊟Accession numbers[edit | edit source]
⊟Protein sequence[edit | edit source]
- MTKKIVAIWAQDEEGVIGKENRLPWHLPAELQHFKETTLNHAILMGRVTFDGMGRRLLPKRETLILTRNPEEKIDGVATFQDVQSVLDWYQAQEKNLYIIGGKQIFQAFEPYLDEVIVTHIHARVEGDTYFPEELDLSLFETVSSKFYAKDEKNPYDFTIQYRKRKEV
⊟Experimental data[edit | edit source]
- protein localization:
- interaction partners:
⊟Expression & Regulation[edit | edit source]
⊟Operon[edit | edit source]
⊟Regulation[edit | edit source]
- regulator:
⊟Expression data[edit | edit source]
- PneumoExpress for strain D39V: SPV_1401 PneumoExpress
⊟Biological Material[edit | edit source]
⊟Mutants[edit | edit source]
⊟Expression vector[edit | edit source]
⊟lacZ fusion[edit | edit source]
⊟GFP fusion[edit | edit source]
⊟two-hybrid system[edit | edit source]
⊟FLAG-tag construct[edit | edit source]
⊟Antibody[edit | edit source]
⊟Other Information[edit | edit source]
You are kindly invited to share additional interesting facts.
⊟Literature[edit | edit source]
⊟References[edit | edit source]
- ↑ Tim van Opijnen, Andrew Camilli
A fine scale phenotype-genotype virulence map of a bacterial pathogen.
Genome Res: 2012, 22(12);2541-51
[PubMed:22826510] [WorldCat.org] [DOI] (I p)