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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae TIGR4
  • locus tag: SP_1714 [new locus tag: SP_RS08475 ]
  • pan locus tag?: PNEUPAN003137000
  • symbol: SP_1714
  • pan gene symbol?: gntR
  • synonym:
  • product: transcriptional regulator, GntR family

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SP_1714 [new locus tag: SP_RS08475 ]
  • symbol: SP_1714
  • product: transcriptional regulator, GntR family
  • replicon: chromosome
  • strand: +
  • coordinates: 1617465..1617830
  • length: 366
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    ATGTCCTGGACATTTGACAACAAAAAACCCATCTATTTACAGATTATGGAGAAAATCAAG
    CTTCAGATTGTTTCCCATACACTGGAACCCAATCAACAACTTCCAACCGTGAGGGAGCTA
    GCTAGCGAGGCTGGTGTCAATCCCAATACCATCCAAAGAGCCTTATCAGACCTTGAACGA
    GAAGGATTTGTCTACAGCAAGCGAACAACTGGACGATTTGTGACTAAGGATAAGGAGCTA
    ATCGCCCAGTCACGCAAACAATTATCAGAAGAAGAATTGGAACACTTCGTTTCCTCCATG
    ACCCATTTTGGCTATGAAAAAGAAGAACTACCAGGCGTAGTCAGTGATTATATTAAAGGA
    GTTTAA
    60
    120
    180
    240
    300
    360
    366

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SP_1714 [new locus tag: SP_RS08475 ]
  • symbol: SP_1714
  • description: transcriptional regulator, GntR family
  • length: 121
  • theoretical pI: 6.26771
  • theoretical MW: 13958.8
  • GRAVY: -0.571901

⊟Function[edit | edit source]

  • TIGRFAM:
    Signal transduction Regulatory functions DNA interactions phosphonate utilization transcriptional regulator PhnR (TIGR03337; HMM-score: 40.6)
    Metabolism Transport and binding proteins Anions phosphonate metabolism transcriptional regulator PhnF (TIGR02325; HMM-score: 39.8)
    Signal transduction Regulatory functions DNA interactions phosphonate metabolism transcriptional regulator PhnF (TIGR02325; HMM-score: 39.8)
    Metabolism Energy metabolism Amino acids and amines histidine utilization repressor (TIGR02018; HMM-score: 38.9)
    Signal transduction Regulatory functions DNA interactions histidine utilization repressor (TIGR02018; HMM-score: 38.9)
    and 12 more
    Signal transduction Regulatory functions DNA interactions trehalose operon repressor (TIGR02404; HMM-score: 29.1)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair repressor LexA (TIGR00498; EC 3.4.21.88; HMM-score: 21.2)
    Signal transduction Regulatory functions DNA interactions repressor LexA (TIGR00498; EC 3.4.21.88; HMM-score: 21.2)
    Signal transduction Regulatory functions DNA interactions CRISPR locus-related DNA-binding protein (TIGR01884; HMM-score: 21)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other iron-sulfur cluster biosynthesis transcriptional regulator SufR (TIGR02702; HMM-score: 16.4)
    Signal transduction Regulatory functions DNA interactions iron-sulfur cluster biosynthesis transcriptional regulator SufR (TIGR02702; HMM-score: 16.4)
    Unknown function General Rrf2 family protein (TIGR00738; HMM-score: 13.8)
    Signal transduction Regulatory functions DNA interactions beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family (TIGR02431; HMM-score: 13.2)
    Metabolism Fatty acid and phospholipid metabolism Biosynthesis fatty acid metabolism transcriptional regulator FadR (TIGR02812; HMM-score: 13.2)
    Metabolism Fatty acid and phospholipid metabolism Degradation fatty acid metabolism transcriptional regulator FadR (TIGR02812; HMM-score: 13.2)
    Signal transduction Regulatory functions DNA interactions fatty acid metabolism transcriptional regulator FadR (TIGR02812; HMM-score: 13.2)
    phosphonate utilization associated transcriptional regulator (TIGR03338; HMM-score: 11.9)
  • TheSEED  :
    • Transcriptional regulator, YtrA family
  • PFAM:
    HTH (CL0123) GntR; Bacterial regulatory proteins, gntR family (PF00392; HMM-score: 59.5)
    and 29 more
    Rrf2; Iron-dependent Transcriptional regulator (PF02082; HMM-score: 25.4)
    HTH_Crp_2; Crp-like helix-turn-helix domain (PF13545; HMM-score: 24.6)
    LexA_DNA_bind; LexA DNA binding domain (PF01726; HMM-score: 24.1)
    TrmB; Sugar-specific transcriptional regulator TrmB (PF01978; HMM-score: 23.3)
    HTH_36; Helix-turn-helix domain (PF13730; HMM-score: 23)
    HTH_IclR; IclR helix-turn-helix domain (PF09339; HMM-score: 22.4)
    MarR; MarR family (PF01047; HMM-score: 21.9)
    MarR_2; MarR family (PF12802; HMM-score: 21.3)
    HTH_24; Winged helix-turn-helix DNA-binding (PF13412; HMM-score: 21)
    Fe_dep_repress; Iron dependent repressor, N-terminal DNA binding domain (PF01325; HMM-score: 19.7)
    HTH_11; HTH domain (PF08279; HMM-score: 18.8)
    HTH_5; Bacterial regulatory protein, arsR family (PF01022; HMM-score: 18.6)
    HTH_28; Helix-turn-helix domain (PF13518; HMM-score: 17.4)
    RPA_C; Replication protein A C terminal (PF08784; HMM-score: 16.9)
    HTH_41; Helix-turn-helix domain (PF14502; HMM-score: 16.6)
    DUF6432; Family of unknown function (DUF6432) (PF20024; HMM-score: 16.5)
    HTH_23; Homeodomain-like domain (PF13384; HMM-score: 15.7)
    RepL; Firmicute plasmid replication protein (RepL) (PF05732; HMM-score: 15.3)
    HTH_Tnp_1; Transposase (PF01527; HMM-score: 15.2)
    HTH_54; ParA helix turn helix domain (PF18607; HMM-score: 15.1)
    HTH_38; Helix-turn-helix domain (PF13936; HMM-score: 15)
    HTH_40; Helix-turn-helix domain (PF14493; HMM-score: 14.9)
    Penicillinase_R; Penicillinase repressor (PF03965; HMM-score: 14.2)
    Suv3_N; Suv3 helical N-terminal domain (PF18114; HMM-score: 13.5)
    no clan defined GPAT_C; Glycerol-3-phosphate acyltransferase C-terminal region (PF19277; HMM-score: 12.5)
    HTH (CL0123) TetR_N; Bacterial regulatory proteins, tetR family (PF00440; HMM-score: 12.4)
    HTH_DeoR; DeoR-like helix-turn-helix domain (PF08220; HMM-score: 12.2)
    HTH_29; Winged helix-turn helix (PF13551; HMM-score: 11.9)
    HTH_Tnp_ISL3; Helix-turn-helix domain of transposase family ISL3 (PF13542; HMM-score: 11.3)

⊟Structure, modifications & cofactors[edit | edit source]

⊟Localization[edit | edit source]

  • PSORTb: unknown (no significant prediction)
    • Cytoplasmic Score: 2.5
    • Cytoplasmic Membrane Score: 2.5
    • Cellwall Score: 2.5
    • Extracellular Score: 2.5
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9952
    • Cytoplasmic Membrane Score: 0.0036
    • Cell wall & surface Score: 0.0002
    • Extracellular Score: 0.001
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.011389
    • TAT(Tat/SPI): 0.000283
    • LIPO(Sec/SPII): 0.000955
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MSWTFDNKKPIYLQIMEKIKLQIVSHTLEPNQQLPTVRELASEAGVNPNTIQRALSDLEREGFVYSKRTTGRFVTKDKELIAQSRKQLSEEELEHFVSSMTHFGYEKEELPGVVSDYIKGV

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator: GntR* (repression) regulon
    GntR*(TF)important in Transport; RegPrecise 

⊟Transcription[edit | edit source]

  • transcription start sites: 1617434, 1617447 [1]

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

  1. ↑ 1.0 1.1 1.2 Indu Warrier, Nikhil Ram-Mohan, Zeyu Zhu, Ariana Hazery, Haley Echlin, Jason Rosch, Michelle M Meyer, Tim van Opijnen
    The Transcriptional landscape of Streptococcus pneumoniae TIGR4 reveals a complex operon architecture and abundant riboregulation critical for growth and virulence.
    PLoS Pathog: 2018, 14(12);e1007461
    [PubMed:30517198] [WorldCat.org] [DOI] (I e)

⊟Relevant publications[edit | edit source]

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