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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae TIGR4
  • locus tag: SP_1898 [new locus tag: SP_RS09430 ]
  • pan locus tag?: PNEUPAN003396000
  • symbol: aga
  • pan gene symbol?: agaN
  • synonym:
  • product: alpha-galactosidase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SP_1898 [new locus tag: SP_RS09430 ]
  • symbol: aga
  • product: alpha-galactosidase
  • replicon: chromosome
  • strand: -
  • coordinates: 1804475..1806637
  • length: 2163
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    2101
    2161
    ATGGGAGTTAGGATAGAGAATAATCTATTTTATGTTGAGAGTAAAAATCTAAGTTTGATT
    ATTGAAAATCGAAATGGCTACTTACTTTTGAAACATTTAGGAAAGACTATTAAGAACTAT
    AAAGGTTCCAATAGTGTTTATGAACGAGACCATGCCTTTTCAGGAAATCCAACGGCTACT
    AATCGAACCTTTAGTTTAGATACTCAGCGACAGATTTTTGGACAACATGGCTTAGGAGAT
    TTTAGGAAACCAACCATACAGGTTCAGCATAGTGTAACTGAAGTAACAGACTTTCGATTT
    GTAGAAGCAAAGATTTTAAAAGGTCAGAATGGTCCACAGGGCTTACCTTCTCCACATAGC
    ATGGACGATACAGAGACTCTTGTCTTAATGTTAGAAGATTCTAAGGCTCAACTTAGTCTG
    ACTTTGTATTATACTACTTTTAATAATGATGCGACTATTGCTAGCTACAGTAAATTAGAT
    AATAATAGTAATCAGGAAGTTGTCATCCATAAAGATTTTTCTTTTATGGCTGATTTTCCA
    GCTGCAGATTACGAAATAGTAACTCTGCAGGGTGCTTATGCTCGTGAAAAGACTGTTAGA
    CGTCAACAGGTAGAACAAGGAATCTTTTCGATTAGTTCAAACCGAGGTGCTTCTGGTCAT
    GCTCAAACACCAGCTCTTCTACTATGCGAACAAGGAGTCACAGAGGATGCTGGGAATGTG
    TTTGCTATTCAACTAATGTATAGTGGCAACTTTGAAGCTTTTGTTCAAAAAAATCAATTG
    AATGAAGTTCGGGTGGCTATTGGCATTAATCCAGAAAACTTTTCTTGGAAGTTAGCTCCT
    GAGGAATACTTTGAAACACCGGTAGCTTTAGTGACTCATTCAGATCAGGGATTAACTGGT
    ATTAGTCATGAAAGTCAGAATTTTGTACTGAAGCACATTATGCTAAGTGAATTTTCTAAA
    AAAGAACGTCCAATTCTAATCAATAACTGGGAAGCTACTTACTTTGACTTTCAGAGAGAA
    AAACTGTTAGAGTTAGCAGATGAAGCTAAGAAAGTTGGCATTGAACTTTTTGTATTAGAT
    GATGGTTGGTTTGGCAATCGTTTTGATGATAATCGTGCTTTAGGTGATTGGGTTGTTAAT
    GAGGAAAAACTGGGTGGAAGTCTAGAAAGTCTGATTTCAGCTATCCATGAAAGAGGTTTG
    CAGTTTGGACTTTGGTTAGAACCCGAAATGATTTCTGTAGATAGTGATTTGTATCGTCAA
    CATCCTGACTGGGCTATTCAGGTTCCTGGCTATGAGCATACTTATTCTCGGAATCAATTA
    GTACTTAATCTTGCCAATCCTCAGGTAGTAGAATACTTGAAAAGTGTCTTAGATCAACTC
    CTATTTTATCATGATATTGATTACATTAAATGGGATATGAACCGCAATATCACTAAGCTA
    GGGAATGGATTAACTTATCTAGAGACACAGATGCAATCTCATCAGTACATGCTGGGGCTT
    TATGAACTCGTTTCTTATCTGACAGAGAAGCACAGCCATATTCTCTTTGAGTCCTGCTCT
    GGTGGTGGTGGACGAAATGATCTTGGTATGATGCGCTATTTCCCACAAGTCTGGGCTAGT
    GATAATACTGATGCCATTGCACGTTTACCAATTCAATACGGTTCATCCTATCTCTATCCA
    ACCATTTCTATGGGGGCTCATGTGTCAGCAGTACCGAATCATCAGATGGGACGAATGACA
    CCATTAGAAACACGTGGCCTTGTAGCAATGATGGGAAATTTGGGCTATGAACTTGATTTG
    ACAAATTTATCAGATGAAGAGAAAGCTACGATTGCTAATCAGGTGAACTTGTATAAAGAA
    TTACGACCAGTAGTTCAGTTAGGACAGCAGTATAGACTAATTAATCCTGATACTGTATCC
    AATGAAGCAGCTGTACAATTTAATTACGGAAATCAAACGATTGTAACCTACGTTCGCGTT
    TTATCTGTTGTAGAGACCATGGAAACAACTTTAAAATTAAAAGATTTGGATGAAGAGGGA
    CTATATAAATTACAGGAAAATGGCGAAGTTTACTCAGGTGCAGAACTAATGTATGCGGGC
    TTAACTGTTATCTTATCCCAAGGAGATTTTTTGAGTAGACAGTATATTTTTAGAAAACTA
    TGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1980
    2040
    2100
    2160
    2163

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SP_1898 [new locus tag: SP_RS09430 ]
  • symbol: Aga
  • description: alpha-galactosidase
  • length: 720
  • theoretical pI: 4.90867
  • theoretical MW: 81716.6
  • GRAVY: -0.335972

⊟Function[edit | edit source]

  • reaction:
    EC 3.2.1.22?  ExPASy
    Alpha-galactosidase Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids
  • TIGRFAM:
  • TheSEED  :
    • Alpha-galactosidase (EC 3.2.1.22), GH36 family
    Carbohydrates Di- and oligosaccharides Fructooligosaccharides(FOS) and Raffinose Utilization  Alpha-galactosidase (EC 3.2.1.22)
    and 1 more
    Carbohydrates Di- and oligosaccharides Lactose and Galactose Uptake and Utilization  Alpha-galactosidase (EC 3.2.1.22)
  • PFAM:
    Glyco_hydro_tim (CL0058) Melibiase; Melibiase (PF02065; HMM-score: 520.2)
    and 6 more
    Gal_mutarotase (CL0103) Glyco_hydro_36N; Glycosyl hydrolase family 36 N-terminal domain (PF16875; HMM-score: 231.5)
    GHD (CL0369) Glyco_hydro_36C; Glycosyl hydrolase family 36 C-terminal domain (PF16874; HMM-score: 53.6)
    Glyco_hydro_tim (CL0058) GHL10; Glycosyl hydrolase-like 10 (PF02638; HMM-score: 23.7)
    Glyco_hydro_31; Glycosyl hydrolases family 31 (PF01055; HMM-score: 23.1)
    GHL6; Hypothetical glycosyl hydrolase 6 (PF14871; HMM-score: 18.2)
    Melibiase_2; Alpha galactosidase A (PF16499; HMM-score: 15)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.007705
    • TAT(Tat/SPI): 0.0018
    • LIPO(Sec/SPII): 0.000533
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MGVRIENNLFYVESKNLSLIIENRNGYLLLKHLGKTIKNYKGSNSVYERDHAFSGNPTATNRTFSLDTQRQIFGQHGLGDFRKPTIQVQHSVTEVTDFRFVEAKILKGQNGPQGLPSPHSMDDTETLVLMLEDSKAQLSLTLYYTTFNNDATIASYSKLDNNSNQEVVIHKDFSFMADFPAADYEIVTLQGAYAREKTVRRQQVEQGIFSISSNRGASGHAQTPALLLCEQGVTEDAGNVFAIQLMYSGNFEAFVQKNQLNEVRVAIGINPENFSWKLAPEEYFETPVALVTHSDQGLTGISHESQNFVLKHIMLSEFSKKERPILINNWEATYFDFQREKLLELADEAKKVGIELFVLDDGWFGNRFDDNRALGDWVVNEEKLGGSLESLISAIHERGLQFGLWLEPEMISVDSDLYRQHPDWAIQVPGYEHTYSRNQLVLNLANPQVVEYLKSVLDQLLFYHDIDYIKWDMNRNITKLGNGLTYLETQMQSHQYMLGLYELVSYLTEKHSHILFESCSGGGGRNDLGMMRYFPQVWASDNTDAIARLPIQYGSSYLYPTISMGAHVSAVPNHQMGRMTPLETRGLVAMMGNLGYELDLTNLSDEEKATIANQVNLYKELRPVVQLGQQYRLINPDTVSNEAAVQFNYGNQTIVTYVRVLSVVETMETTLKLKDLDEEGLYKLQENGEVYSGAELMYAGLTVILSQGDFLSRQYIFRKL

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator: CcpA regulon
    CcpA(TF)important in Global catabolite repression; RegPrecise 

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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