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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae TIGR4
  • locus tag: SP_2093 [new locus tag: SP_RS10655 ]
  • pan locus tag?: PNEUPAN003760000
  • symbol: SP_2093
  • pan gene symbol?: —
  • synonym:
  • product: hypothetical protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SP_2093 [new locus tag: SP_RS10655 ]
  • symbol: SP_2093
  • product: hypothetical protein
  • replicon: chromosome
  • strand: +
  • coordinates: 2001118..2002086
  • length: 969
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: AE005672 (2001118..2002086) NCBI
  • BioCyc:
  • MicrobesOnline: 117511 MicrobesOnline
  • PneumoBrowse for strain D39V:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    TTGCGGACACTATCAAAGAAAAAGATTATGGAGAACAAATTTGTAGAATTTATCGAAAAC
    AATAAAAAAGTAATCATTTCATCAGTTGCAGTTGGTGTTGTATTGGTATTAGGGTTTGGA
    TGGTATTCATATAACCAACAACAAGCAGAACAACAAGCAAAAATTGTACAATTAGAAAAA
    GATAGCAAATCAGACAAAGAACAAGTTGATAAACTATTTGAATCATTTGATGCATCTTCA
    GATGAATCTATTTCTAAATTAAAAGAACTATCTGAAACTTCACTTAAAACCGATGCAGGT
    AAAGACTATCTTAATAACAAAGTCAAAGAATCATCTAAAGCAATTGTAGATTTTCATTTG
    CAAAAAGGTTTGGCTTATGATGTTAAAGATTCAGATGACAAATTTAAAGATAAAGCAACT
    CTTGAAACAAATGTAAAAGAAATTACAAAACAAATTGATTTTATCAAAAAAGTTGATGAA
    ACTTTTAAACAAGAGAATTTGGAAGAAACTCTTAAATCTCTAAATGATCTTGTTGATAAA
    TATCAAAAACAAATCGAACTTTTGAAGAAAGAAGAAGAAAAAGCTGCTGAAAAAGCTGCT
    GAAAAAGCAAAGGAATCTTCTAGTCAAAGTAATTCTTCTGGTAGTGCTTCTAATGAGTCT
    TATAATGGATCTTCCAATTCAAATGTAGATTATAGTTCATCTGAACAAACTAATGGATAT
    TCAAATAATTATGGCGGTCAAGATTATTCTGGTTCAGGAGATAGTTCAACAAATGGTGGA
    TCATCAGAACAATATTCATCTAGCAATTCAAACAGCGGAGCAAATAATGTCTACAGATAT
    AAAGGCACTGGTGCTGACGGCTATCAAAGATACTACTACAAAGATCATAATAATGGAGAT
    GTGTATGATGACGATGGAAATTACCTTGGGAACTTTGGTGGCGGCATTGCAGAACCTAGT
    CAACGCTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    969

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SP_2093 [new locus tag: SP_RS10655 ]
  • symbol: SP_2093
  • description: hypothetical protein
  • length: 322
  • theoretical pI: 4.71259
  • theoretical MW: 35814.5
  • GRAVY: -1.04286

⊟Function[edit | edit source]

  • TIGRFAM:
    early transcribed membrane protein (ETRAMP) family (TIGR01495; HMM-score: 15.7)
    phage lysis regulatory protein, LysB family (TIGR03495; HMM-score: 13.5)
    and 2 more
    Cellular processes Cellular processes Cell division chromosome segregation protein SMC (TIGR02168; HMM-score: 6.5)
    Genetic information processing DNA metabolism Chromosome-associated proteins chromosome segregation protein SMC (TIGR02168; HMM-score: 6.5)
  • TheSEED  :
    • FIG01117121: hypothetical protein
  • PFAM:
    TPR (CL0020) TPR_21; Tetratricopeptide repeat-like domain (PF09976; HMM-score: 20.8)
    no clan defined SlyX; SlyX (PF04102; HMM-score: 18.2)
    and 19 more
    FlxA; FlxA-like protein (PF14282; HMM-score: 16.1)
    ETRAMP; Malarial early transcribed membrane protein (ETRAMP) (PF09716; HMM-score: 15.7)
    TMP_2; Prophage tail length tape measure protein (PF06791; HMM-score: 15.6)
    Scaffold; Scaffold domain (PF20142; HMM-score: 13.9)
    Mitofilin; Mitochondrial inner membrane protein (PF09731; HMM-score: 13.4)
    DUF4307; Domain of unknown function (DUF4307) (PF14155; HMM-score: 12.8)
    FtsL (CL0225) DivIC; Septum formation initiator (PF04977; HMM-score: 12.3)
    no clan defined LapA_dom; Lipopolysaccharide assembly protein A domain (PF06305; HMM-score: 11.7)
    MRPL52; Mitoribosomal protein mL52 (PF18699; HMM-score: 11.6)
    YebO; YebO-like protein (PF13974; HMM-score: 10.2)
    Histone_HNS; H-NS histone family (PF00816; HMM-score: 9.8)
    Traffic (CL0147) Sec20; Sec20 (PF03908; HMM-score: 9.7)
    no clan defined DUF948; Bacterial protein of unknown function (DUF948) (PF06103; HMM-score: 8)
    Ax_dynein_light; Axonemal dynein light chain (PF10211; HMM-score: 7.7)
    DinB (CL0310) DUF1993; Domain of unknown function (DUF1993) (PF09351; HMM-score: 7.5)
    no clan defined CCDC-167; Coiled-coil domain-containing protein 167 (PF15188; HMM-score: 7.2)
    LMBR1; LMBR1-like membrane protein (PF04791; HMM-score: 6.2)
    Saf4_Yju2; Saf4/Yju2 protein (PF04502; HMM-score: 6.1)
    DUF6080; Family of unknown function (DUF6080) (PF19558; HMM-score: 5.9)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: unknown (no significant prediction)
    • Cytoplasmic Score: 2.5
    • Cytoplasmic Membrane Score: 2.5
    • Cellwall Score: 2.5
    • Extracellular Score: 2.5
    • Internal Helix: 1
  • DeepLocPro: Extracellular
    • Cytoplasmic Score: 0.0001
    • Cytoplasmic Membrane Score: 0.2428
    • Cell wall & surface Score: 0.0621
    • Extracellular Score: 0.695
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.096821
    • TAT(Tat/SPI): 0.000863
    • LIPO(Sec/SPII): 0.004628
  • predicted transmembrane helices (TMHMM): 1

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MRTLSKKKIMENKFVEFIENNKKVIISSVAVGVVLVLGFGWYSYNQQQAEQQAKIVQLEKDSKSDKEQVDKLFESFDASSDESISKLKELSETSLKTDAGKDYLNNKVKESSKAIVDFHLQKGLAYDVKDSDDKFKDKATLETNVKEITKQIDFIKKVDETFKQENLEETLKSLNDLVDKYQKQIELLKKEEEKAAEKAAEKAKESSSQSNSSGSASNESYNGSSNSNVDYSSSEQTNGYSNNYGGQDYSGSGDSSTNGGSSEQYSSSNSNSGANNVYRYKGTGADGYQRYYYKDHNNGDVYDDDGNYLGNFGGGIAEPSQR

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

  • PneumoExpress for strain D39V:

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

  1. ↑ Indu Warrier, Nikhil Ram-Mohan, Zeyu Zhu, Ariana Hazery, Haley Echlin, Jason Rosch, Michelle M Meyer, Tim van Opijnen
    The Transcriptional landscape of Streptococcus pneumoniae TIGR4 reveals a complex operon architecture and abundant riboregulation critical for growth and virulence.
    PLoS Pathog: 2018, 14(12);e1007461
    [PubMed:30517198] [WorldCat.org] [DOI] (I e)

⊟Relevant publications[edit | edit source]

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