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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 09-APR-2021

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae TIGR4
  • locus tag: SP_RS00265 [old locus tag: SP_0044 ]
  • pan locus tag?: PNEUPAN000688000
  • symbol: SP_RS00265
  • pan gene symbol?: purC
  • synonym:
  • product: phosphoribosylaminoimidazolesuccinocarboxamide synthase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SP_RS00265 [old locus tag: SP_0044 ]
  • symbol: SP_RS00265
  • product: phosphoribosylaminoimidazolesuccinocarboxamide synthase
  • replicon: chromosome
  • strand: +
  • coordinates: 44501..45208
  • length: 708
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_003028 (44501..45208) NCBI
  • BioCyc: SP_RS00265 BioCyc
  • MicrobesOnline: see SP_0044
  • PneumoBrowse for strain D39V: SPV_0051 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    ATGTCAAAACAATTGATCTATTCGGGAAAAGCTAAAGATATCTATACAACTGAGGATGAA
    AATCTTATTATTTCAACTTACAAGGACCAGGCGACTGCTTTCAACGGTGTCAAGAAGGAG
    CAGATTGCAGGTAAGGGAGTCTTGAATAATCAGATCTCATCTTTTATTTTTGAGAAATTA
    AATGTGGCTGGTGTGGCGACTCACTTTGTGGAGAAACTTTCAGACACGGAACAACTCAAT
    AAAAAGGTTAAGATTATTCCTTTGGAAGTCGTGCTCCGCAACTATACTGCTGGTTCCTTT
    TCAAAACGTTTTGGTGTGGATGAGGGAATCGCCTTGGAGACTCCGATTGTCGAATTTTAC
    TACAAAAATGATGATTTGGATGATCCATTTATCAATGATGAGCATGTGAAATTCCTACAG
    ATTGCGGGTGACCAGCAGATTGCCTACTTGAAGGAAGAAACGCGTCGTATCAATGAACTA
    TTGAAAGTCTGGTTTGCTGAGATTGGGCTTAAATTGATTGACTTTAAGCTAGAGTTCGGT
    TTTGACAAGGATGGCAAGATTATCTTGGCAGACGAATTTTCACCAGATAACTGCCGCTTG
    TGGGACGCTGATGGCAACCACATGGATAAGGATGTTTTCCGTAGAGGATTGGGAGAACTA
    ACCGACGTTTATGAGATTGTTTGGGAAAAGTTGCAGGAATTGAAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    708

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SP_RS00265 [old locus tag: SP_0044 ]
  • symbol: SP_RS00265
  • description: phosphoribosylaminoimidazolesuccinocarboxamide synthase
  • length: 235
  • theoretical pI: 4.6384
  • theoretical MW: 27002.5
  • GRAVY: -0.35234

⊟Function[edit | edit source]

  • reaction:
    EC 6.3.2.6?  ExPASy
    Phosphoribosylaminoimidazolesuccinocarboxamide synthase ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate
  • TIGRFAM:
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Purine ribonucleotide biosynthesis phosphoribosylaminoimidazolesuccinocarboxamide synthase (TIGR00081; EC 6.3.2.6; HMM-score: 248.8)
  • TheSEED: see SP_0044
  • PFAM:
    no clan defined SAICAR_synt; SAICAR synthetase (PF01259; HMM-score: 223.8)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.007106
    • TAT(Tat/SPI): 0.000208
    • LIPO(Sec/SPII): 0.000468
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MSKQLIYSGKAKDIYTTEDENLIISTYKDQATAFNGVKKEQIAGKGVLNNQISSFIFEKLNVAGVATHFVEKLSDTEQLNKKVKIIPLEVVLRNYTAGSFSKRFGVDEGIALETPIVEFYYKNDDLDDPFINDEHVKFLQIAGDQQIAYLKEETRRINELLKVWFAEIGLKLIDFKLEFGFDKDGKIILADEFSPDNCRLWDADGNHMDKDVFRRGLGELTDVYEIVWEKLQELK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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