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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 23-APR-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae TIGR4
  • locus tag: SP_RS01715 [old locus tag: SP_0351 ]
  • pan locus tag?: PNEUPAN000077000
  • symbol: cps4F
  • pan gene symbol?: cps4F
  • synonym:
  • product: capsular polysaccharide biosynthesis protein Cps4F

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SP_RS01715 [old locus tag: SP_0351 ]
  • symbol: cps4F
  • product: capsular polysaccharide biosynthesis protein Cps4F
  • replicon: chromosome
  • strand: +
  • coordinates: 324634..325863
  • length: 1230
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_003028 (324634..325863) NCBI
  • BioCyc:
  • MicrobesOnline: see SP_0351
  • PneumoBrowse for strain D39V:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    ATGAAAATACTATTTGTTTGCCAACATTATAAGCCAGAACCATTCAGGTTGTCAGATATT
    TGTGAAGATTTAGTTCGAAAAGGGCATGAAGTCTCTGTTTTGGCTGGGATTCCTAATTAC
    CCTGAAGGGAAGATATATGCAGATTATCGTCATAATAAAAAAAGACGTGAGATTATAGAA
    GGTGTTACGATATATCGTTCTTATACAATCCCTAGAAAAAAAAGTGTTGTATTTCGATTG
    TTGAATTATTTTAGCTTTGCAATTAGTTCTACTTTAGGAGTTTTATTGGGGAGGTATAAA
    ACGAAAGATGGATCGAATTTTGACTGTGTATTCGTTAACCAATTGTCTCCAGTTATGATG
    GCATGGGCTGGTATGGCTTATAAAAAAAAATATAAGAAACCGATGTTTCTATATTGTATG
    GATGTTTGGCCAGATAGTTTAACCGTAGGTGGAGTGAAACAAGATGGCTTGATTTTCAAG
    CTGTTTAAATTTATCTCAAAAAAAGTTTACCGAGCTAGTGATTATATATTTGTCACTAGT
    CCATCATTTAAAAATTATTTTGTGAAGCAATTTGACATATCCGAACAAAAGATTACATAT
    TTGCCACAATATGCAGAAGATCTTTTTATCCCTGATGAATCTATAGTTAATAAAGAAAGT
    GTTGACCTAACTTTTGCTGGTAATATTGGCAAAGCACAAAATTTGGAAACTATTTTGAAA
    GCTGCCAGTTTGATAGAGAAGAATACCAATTTACCCAAGAAAATTCATTTTCATTTTGTT
    GGAGATGGTACGGAATTGTTAAGCATGAAAGCATTAGCTCATGAATTGGAGTTAAAGAAT
    ATTTCCTTCTATGGAAGACGTTCTTTGGAGGAAATGCCATCCTTCTATAAAAAATCAGAT
    GCTATGTTAGTTTCTTTAATAGGAGACTCGATAGTTTCTCGTACTATACCTGGGAAGGTA
    CAATCTTATATGGCGGCAGGCAAACCAATTATAGGTGCAATTTCAGGAGATGCTAAAATA
    ATTGTAGAAGAAGCAAATTGTGGATATGTTAGTCCCGAACGAGATGTAAAACAATTGGCA
    AAAAATATTTGTAAATTTAGTATGTTATCTATTAAGAGACAAAGAGAGTTAGGAAAGAAA
    GCTCGTTGTTACTATGAAAATCACTTTTCAAAAGAGCAGTTTATGCTCGAACTGGAGACA
    TGTTTAGAGAGGGAAAGTAAGAAAGAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1230

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SP_RS01715 [old locus tag: SP_0351 ]
  • symbol: Cps4F
  • description: capsular polysaccharide biosynthesis protein Cps4F
  • length: 409
  • theoretical pI: 9.64159
  • theoretical MW: 46922.4
  • GRAVY: -0.245232

⊟Function[edit | edit source]

  • TIGRFAM:
    colanic acid biosynthesis glycosyltransferase WcaI (TIGR04007; EC 2.4.-.-; HMM-score: 68.8)
    and 9 more
    sugar transferase, PEP-CTERM/EpsH1 system associated (TIGR03088; HMM-score: 47.6)
    PEP-CTERM/exosortase A-associated glycosyltransferase, Daro_2409 family (TIGR04063; EC 2.4.-.-; HMM-score: 46.3)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Glutathione and analogs N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA (TIGR03999; EC 2.4.1.-; HMM-score: 34.4)
    colanic acid biosynthesis glycosyltransferase WcaL (TIGR04005; EC 2.4.-.-; HMM-score: 28.4)
    glycosyltransferase, GG-Bacteroidales peptide system (TIGR04157; EC 2.4.1.-; HMM-score: 27.4)
    D-inositol-3-phosphate glycosyltransferase (TIGR03449; EC 2.4.1.250; HMM-score: 21.3)
    sugar transferase, PEP-CTERM/EpsH1 system associated (TIGR03087; HMM-score: 19.8)
    Cellular processes Cellular processes Sporulation and germination anti-sigma F factor antagonist (TIGR02886; HMM-score: 15)
    Signal transduction Regulatory functions Protein interactions anti-sigma F factor antagonist (TIGR02886; HMM-score: 15)
  • TheSEED: see SP_0351
  • PFAM:
    GT-B (CL0113) Glycos_transf_1; Glycosyl transferases group 1 (PF00534; HMM-score: 68.5)
    Glyco_trans_1_4; Glycosyl transferases group 1 (PF13692; HMM-score: 57.9)
    and 2 more
    Glyco_transf_4; Glycosyltransferase Family 4 (PF13439; HMM-score: 40.9)
    Glyco_trans_4_4; Glycosyl transferase 4-like domain (PF13579; HMM-score: 28.3)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: unknown (no significant prediction)
    • Cytoplasmic Score: 2.5
    • Cytoplasmic Membrane Score: 2.5
    • Cellwall Score: 2.5
    • Extracellular Score: 2.5
    • Internal Helices: 2
  • DeepLocPro: Cytoplasmic Membrane
    • Cytoplasmic Score: 0.0259
    • Cytoplasmic Membrane Score: 0.9321
    • Cell wall & surface Score: 0.0003
    • Extracellular Score: 0.0417
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.012456
    • TAT(Tat/SPI): 0.000306
    • LIPO(Sec/SPII): 0.002324
  • predicted transmembrane helices (TMHMM): 1

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MKILFVCQHYKPEPFRLSDICEDLVRKGHEVSVLAGIPNYPEGKIYADYRHNKKRREIIEGVTIYRSYTIPRKKSVVFRLLNYFSFAISSTLGVLLGRYKTKDGSNFDCVFVNQLSPVMMAWAGMAYKKKYKKPMFLYCMDVWPDSLTVGGVKQDGLIFKLFKFISKKVYRASDYIFVTSPSFKNYFVKQFDISEQKITYLPQYAEDLFIPDESIVNKESVDLTFAGNIGKAQNLETILKAASLIEKNTNLPKKIHFHFVGDGTELLSMKALAHELELKNISFYGRRSLEEMPSFYKKSDAMLVSLIGDSIVSRTIPGKVQSYMAAGKPIIGAISGDAKIIVEEANCGYVSPERDVKQLAKNICKFSMLSIKRQRELGKKARCYYENHFSKEQFMLELETCLERESKKE

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site: see SP_0351

⊟Expression data[edit | edit source]

  • PneumoExpress for strain D39V:

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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