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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 23-APR-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae TIGR4
  • locus tag: SP_RS02695 [old locus tag: SP_0547 ]
  • pan locus tag?: PNEUPAN001427000
  • symbol: SP_RS02695
  • pan gene symbol?: pncP
  • synonym:
  • product: CPBP family intramembrane glutamic endopeptidase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SP_RS02695 [old locus tag: SP_0547 ]
  • symbol: SP_RS02695
  • product: CPBP family intramembrane glutamic endopeptidase
  • replicon: chromosome
  • strand: +
  • coordinates: 518517..519128
  • length: 612
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_003028 (518517..519128) NCBI
  • BioCyc:
  • MicrobesOnline: see SP_0547
  • PneumoBrowse for strain D39V: SPV_0475 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    ATGGAGTTTTTTGATAAATTTCATGCCTTGTGTTTTGGATTTTTAGTACTAATAATTGTC
    ATTACAGTTCCTTATACGATTAACCATGGGGGTTTTTTTCAAAATGAATCTGCATTGATT
    CTTGTAAGTCTTCTTGTAACCTCGCTGAGTGTTGCTTATGCTAGAAAGTTTGAAATGATT
    TCTTTTGGGATGTTAAGCAAGAAACAACTTTTGCTTTTCATTGCAATCTTTCTTCTAAGT
    GTACTTGAGACGCTGGTTTATATTCATTTCTTCGCTGTTTCTTCTGGCTCAGGGGTCCAA
    CACTTGGCGGAAGTCAGCAGAGGAATTTCCCTGTCTTTGATTTTGACTACCTCAGTTTTT
    GGCCCCATCCAGGAGGAACTCATTTTCAGAGGACTTCTTCAAGGTGCGGTTTTTGACAAT
    TCTTGGTTAGGGCTTGTGCTAACTTCCTCTCTCTTTTCTTTCATGCATGGACCTTCTAAT
    GTCCCTTCGTTTATTTTTTATCTACTTGGGGGTTTGTTGCTGGGCTTTGCTTATAAAAAG
    AGTCAAAACCTATGGGTTTCTACTCTAGTCCATATGCTTTACAACAGTTGGCCACTCTTA
    TATTATTTATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    612

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SP_RS02695 [old locus tag: SP_0547 ]
  • symbol: SP_RS02695
  • description: CPBP family intramembrane glutamic endopeptidase
  • length: 203
  • theoretical pI: 7.7542
  • theoretical MW: 22741.8
  • GRAVY: 0.911823

⊟Function[edit | edit source]

  • reaction:
    EC 3.4.-.-?  ExPASy
  • TIGRFAM:
  • TheSEED: see SP_0547
  • PFAM:
    Peptidase_U (CL0472) Rce1-like; Type II CAAX prenyl endopeptidase Rce1-like (PF02517; HMM-score: 67)
    and 1 more
    no clan defined DUF6442; Family of unknown function (DUF6442) (PF20040; HMM-score: 7.9)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 4
  • DeepLocPro: Cytoplasmic Membrane
    • Cytoplasmic Score: 0.0008
    • Cytoplasmic Membrane Score: 0.9752
    • Cell wall & surface Score: 0.0002
    • Extracellular Score: 0.0239
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.022429
    • TAT(Tat/SPI): 0.000688
    • LIPO(Sec/SPII): 0.004272
  • predicted transmembrane helices (TMHMM): 4

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MEFFDKFHALCFGFLVLIIVITVPYTINHGGFFQNESALILVSLLVTSLSVAYARKFEMISFGMLSKKQLLLFIAIFLLSVLETLVYIHFFAVSSGSGVQHLAEVSRGISLSLILTTSVFGPIQEELIFRGLLQGAVFDNSWLGLVLTSSLFSFMHGPSNVPSFIFYLLGGLLLGFAYKKSQNLWVSTLVHMLYNSWPLLYYL

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

  1. ↑ Indu Warrier, Nikhil Ram-Mohan, Zeyu Zhu, Ariana Hazery, Haley Echlin, Jason Rosch, Michelle M Meyer, Tim van Opijnen
    The Transcriptional landscape of Streptococcus pneumoniae TIGR4 reveals a complex operon architecture and abundant riboregulation critical for growth and virulence.
    PLoS Pathog: 2018, 14(12);e1007461
    [PubMed:30517198] [WorldCat.org] [DOI] (I e)

⊟Relevant publications[edit | edit source]

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