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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 23-APR-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae TIGR4
  • locus tag: SP_RS08540 [old locus tag: SP_1726 ]
  • pan locus tag?: PNEUPAN003149000
  • symbol: SP_RS08540
  • pan gene symbol?: mvaA
  • synonym:
  • product: hydroxymethylglutaryl-CoA reductase, degradative

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SP_RS08540 [old locus tag: SP_1726 ]
  • symbol: SP_RS08540
  • product: hydroxymethylglutaryl-CoA reductase, degradative
  • replicon: chromosome
  • strand: -
  • coordinates: 1629797..1631071
  • length: 1275
  • essential: yes [1] DEG

⊟Accession numbers[edit | edit source]

  • Location: NC_003028 (1629797..1631071) NCBI
  • BioCyc:
  • MicrobesOnline: see SP_1726
  • PneumoBrowse for strain D39V: SPV_1536 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    ATGAAGATAAGTTGGAATGGATTTTCTAAAAAATCATACCAAGAGCGCCTCGAGCTGTTA
    AAAGCTCAGGCGCTCCTTAGTCCTGAGAGACAAGCTAGTCTGGAGAAGGATGAACAGATG
    AGCGTGACTGTGGCAGACCAGCTGAGTGAGAATGTAGTGGGAACTTTTTCTCTGCCTTAT
    TCACTGGTTCCGGAGGTACTTGTCAACGGTCAGGAATACACCGTTCCCTATGTGACAGAA
    GAACCCTCTGTGGTTGCGGCGGCCAGCTATGCCAGCAAAATCATCAAGCGTGCAGGTGGT
    TTTACTGCACAAGTCCATCAGCGACAGATGATTGGGCAGGTAGCCCTTTATCAAGTTGCT
    AATCCTAAACTAGCGCAAGAGAAGATTGCCAGCAAGAAAGCGGAGCTCTTGGAGCTTGCC
    AATCAAGCCTATCCTTCTATCGTTAAACGTGGAGGTGGGGCGCGTGATCTGCATGTCGAG
    CAGATAAAAGGCGAACCAGACTTTCTCGTTGTTTATATTCATGTCGATACCCAGGAAGCC
    ATGGGTGCCAATATGCTCAACACCATGCTGGAAGCCTTGAAACCAGTCTTAGAAGAACTC
    AGTCAGGGACAGAGTCTCATGGGAATCCTGTCCAACTACGCGACCGATTCTCTGGTGACT
    GCAAGCTGTCGCATCGCCTTTCGCTACTTGAGCCGCCAAAAGGATCAAGGACGAGAGATT
    GCGGAGAAAATTGCGTTGGCTAGTCAGTTTGCGCAGGCTGATCCTTACCGAGCTGCTACT
    CATAATAAAGGAATTTTTAATGGTATTGATGCGATTTTGATTGCCACTGGTAATGACTGG
    CGTGCCATCGAAGCTGGGGCCCATGCCTTTGCCAGTCGAGATGGACGCTATCAAGGTCTT
    AGCTGCTGGACGCTGGACCTTGAAAGAGAAGAATTGGTCGGTGAGATGACCCTGCCCATG
    CCTGTAGCGACTAAGGGTGGCTCTATCGGCCTCAACCCACGTGTAGTTCTCAGTCATGAT
    CTACTAGGAAATCCTTCTGCCAGAGAATTAGCCCAGATTATCGTGTCCATCGGTCTTGCT
    CAAAATTTTGCAGCCCTCAAAGCCTTGGTAAGTACGGGCATCCAGCAAGGCCACATGAAA
    CTACAGGCCAAATCCCTAGCTCTCCTAGCTGGGGCTAGTGAATCTGAAGTTGCTCCCCTA
    GTAGAGCGCCTCATCTCAGATAAAACCTTTAACCTAGAGACAGCCCAGCGCTATCTCGAA
    AATTTAAGATCATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1275

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SP_RS08540 [old locus tag: SP_1726 ]
  • symbol: SP_RS08540
  • description: hydroxymethylglutaryl-CoA reductase, degradative
  • length: 424
  • theoretical pI: 6.41792
  • theoretical MW: 46211.5
  • GRAVY: -0.112264

⊟Function[edit | edit source]

  • reaction:
    EC 1.1.1.88?  ExPASy
    Hydroxymethylglutaryl-CoA reductase (R)-mevalonate + CoA + 2 NAD+ = 3-hydroxy-3-methylglutaryl-CoA + 2 NADH
  • TIGRFAM:
    Metabolism Energy metabolism Other hydroxymethylglutaryl-CoA reductase, degradative (TIGR00532; EC 1.1.1.88; HMM-score: 332.7)
    and 2 more
    Metabolism Central intermediary metabolism Other hydroxymethylglutaryl-CoA reductase (NADPH) (TIGR00533; EC 1.1.1.34; HMM-score: 59.6)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids 3-hydroxy-3-methylglutaryl-coenzyme A reductase (TIGR00920; HMM-score: 43.9)
  • TheSEED: see SP_1726
  • PFAM:
    no clan defined HMG-CoA_red; Hydroxymethylglutaryl-coenzyme A reductase (PF00368; HMM-score: 371.3)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9861
    • Cytoplasmic Membrane Score: 0.0007
    • Cell wall & surface Score: 0.0003
    • Extracellular Score: 0.0129
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.011477
    • TAT(Tat/SPI): 0.001907
    • LIPO(Sec/SPII): 0.001215
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MKISWNGFSKKSYQERLELLKAQALLSPERQASLEKDEQMSVTVADQLSENVVGTFSLPYSLVPEVLVNGQEYTVPYVTEEPSVVAAASYASKIIKRAGGFTAQVHQRQMIGQVALYQVANPKLAQEKIASKKAELLELANQAYPSIVKRGGGARDLHVEQIKGEPDFLVVYIHVDTQEAMGANMLNTMLEALKPVLEELSQGQSLMGILSNYATDSLVTASCRIAFRYLSRQKDQGREIAEKIALASQFAQADPYRAATHNKGIFNGIDAILIATGNDWRAIEAGAHAFASRDGRYQGLSCWTLDLEREELVGEMTLPMPVATKGGSIGLNPRVVLSHDLLGNPSARELAQIIVSIGLAQNFAALKALVSTGIQQGHMKLQAKSLALLAGASESEVAPLVERLISDKTFNLETAQRYLENLRS

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

  1. ↑ Jane A Thanassi, Sandra L Hartman-Neumann, Thomas J Dougherty, Brian A Dougherty, Michael J Pucci
    Identification of 113 conserved essential genes using a high-throughput gene disruption system in Streptococcus pneumoniae.
    Nucleic Acids Res: 2002, 30(14);3152-62
    [PubMed:12136097] [WorldCat.org] [DOI] (I p)    Tim van Opijnen, Andrew Camilli
    A fine scale phenotype-genotype virulence map of a bacterial pathogen.
    Genome Res: 2012, 22(12);2541-51
    [PubMed:22826510] [WorldCat.org] [DOI] (I p)
  2. ↑ 2.0 2.1 Indu Warrier, Nikhil Ram-Mohan, Zeyu Zhu, Ariana Hazery, Haley Echlin, Jason Rosch, Michelle M Meyer, Tim van Opijnen
    The Transcriptional landscape of Streptococcus pneumoniae TIGR4 reveals a complex operon architecture and abundant riboregulation critical for growth and virulence.
    PLoS Pathog: 2018, 14(12);e1007461
    [PubMed:30517198] [WorldCat.org] [DOI] (I e)

⊟Relevant publications[edit | edit source]

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