PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BM6001

serotype 19F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7465

serotype 1

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 31-JAN-2014

⊟Summary

• organism: Streptococcus pneumoniae A026
• locus tag: T308_03450 [new locus tag: T308_RS03495 ]
• pan locus tag^?: PNEUPAN001677000
• symbol: T308_03450
• pan gene symbol^?: mta
• synonym:
• product: MerR family transcriptional regulator

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: T308_03450 [new locus tag: T308_RS03495 ]
• symbol: T308_03450
• product: MerR family transcriptional regulator
• replicon: chromosome
• strand: +
• coordinates: 676411..677082
• length: 672
• essential: unknown

⊟Accession numbers

• Location: CP006844 (676411..677082) NCBI
• BioCyc: see T308_RS03495
• MicrobesOnline:
• PneumoBrowse for strain D39V: SPV_0643 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  541
  601
  661
  
  TTGGTCCCCTTAAAGTCGGAAAACGGCTATCGAACCTATAGTCAAGAGGATTTGGAACGC
  CTTCAGGTCATTCTTTACTACAAATATCTAGGCTTTTCTTTAGAGAAAATAGCAGAGCTG
  TTAAAGGAAGAAAGGACAGATTTATTGCCCCATTTAACTAGGCAGTTGGACTATCTAACT
  CGCGAAAGGCAACATCTGGATACCTTGATTTCCACCTTGCAAAAAACTATTCAAGAACAA
  AAAGGAGAAAGAAAAATGACCATTGAGGAAAAATTCACGGGATTTAGCTATCAAGACAAT
  CAAAAATACCACCAAGAAGCGGTAGAGAAATATGGTCAAGAAGTCATGGGACAAGCGCTT
  GAACGCCAAAAAGGTCACGAAAACGAGGCTACGGCCGCCTTTAACCAAGTCTTTCAAACT
  TTGGCACAAAATCTTCAAGCTGGTTTACCTGCAACAGCAACCGAAAACCAAGAGCAAGCA
  GCCAAGCTCTTGCAAGCCATTCGCACTTATGGATTTGACTGCTCTATTGAGGTATTCGGT
  CATATCGGTAAAGGTTACGTCTACAACCCAGAGTTTAAGGAAAACATTGACAAGTTTGGT
  TCTGGAACAGCCCAGTACACGTCAGATGCCATTGCGGCTTACGTTCAGACAAATGCAGAA
  AAAATAGGCTAG
  60
  120
  180
  240
  300
  360
  420
  480
  540
  600
  660
  672
  

⊟Protein

⊟General

• locus tag: T308_03450 [new locus tag: T308_RS03495 ]
• symbol: T308_03450
• description: MerR family transcriptional regulator
• length: 223
• theoretical pI: 5.18712
• theoretical MW: 25597.5
• GRAVY: -0.698655

⊟Function

• TIGRFAM:
  Signal transduction Regulatory functions DNA interactions Cu(I)-responsive transcriptional regulator (TIGR02044; HMM-score: 36.1)
  Cellular processes Cellular processes Detoxification Hg(II)-responsive transcriptional regulator (TIGR02051; HMM-score: 34.5)
  Signal transduction Regulatory functions DNA interactions Hg(II)-responsive transcriptional regulator (TIGR02051; HMM-score: 34.5)
  Signal transduction Regulatory functions DNA interactions Zn(II)-responsive transcriptional regulator (TIGR02043; HMM-score: 33.1)
  and 2 more
  Signal transduction Regulatory functions DNA interactions Cd(II)/Pb(II)-responsive transcriptional regulator (TIGR02047; HMM-score: 21.8)
  4-nitrotryptophan synthase (TIGR04458; EC 1.-.-.-; HMM-score: 15.4)
• TheSEED: data available for TIGR4
• PFAM:
  no clan defined TipAS; TipAS antibiotic-recognition domain (PF07739; HMM-score: 78.6)
  and 10 more
  HTH (CL0123) MerR-DNA-bind; MerR, DNA binding (PF09278; HMM-score: 37.2)
  MerR_1; MerR HTH family regulatory protein (PF13411; HMM-score: 33.4)
  no clan defined Enkurin; Calmodulin-binding (PF13864; HMM-score: 15.9)
  IcmF-related_N; IcmF-related N-terminal domain (PF14331; HMM-score: 12.8)
  DNA_primase_lrg (CL0242) DNA_primase_lrg; Eukaryotic and archaeal DNA primase, large subunit (PF04104; HMM-score: 12.7)
  PDDEXK (CL0236) VRR_NUC; VRR-NUC domain (PF08774; HMM-score: 12.5)
  no clan defined STAT_int; STAT protein, protein interaction domain (PF02865; HMM-score: 11.1)
  DUF2203; Uncharacterized conserved protein (DUF2203) (PF09969; HMM-score: 11.1)
  Exonuc_VII_L; Exonuclease VII, large subunit (PF02601; HMM-score: 9.9)
  ISG65-75; Invariant surface glycoprotein (PF11727; HMM-score: 9.1)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: Cytoplasmic
  • Cytoplasmic Score: 7.5
  • Cytoplasmic Membrane Score: 1.15
  • Cellwall Score: 0.62
  • Extracellular Score: 0.73
  • Internal Helices: 0
• DeepLocPro: Cytoplasmic
  • Cytoplasmic Score: 0.9912
  • Cytoplasmic Membrane Score: 0.0008
  • Cell wall & surface Score: 0.0004
  • Extracellular Score: 0.0076
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.000886
  • TAT(Tat/SPI): 0.000168
  • LIPO(Sec/SPII): 0.000211
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: AGZ47468 NCBI
• UniProt:

⊟Protein sequence

• MVPLKSENGYRTYSQEDLERLQVILYYKYLGFSLEKIAELLKEERTDLLPHLTRQLDYLTRERQHLDTLISTLQKTIQEQKGERKMTIEEKFTGFSYQDNQKYHQEAVEKYGQEVMGQALERQKGHENEATAAFNQVFQTLAQNLQAGLPATATENQEQAAKLLQAIRTYGFDCSIEVFGHIGKGYVYNPEFKENIDKFGSGTAQYTSDAIAAYVQTNAEKIG

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• regulator:

⊟Transcription

• transcription start site:

⊟Expression data

• PneumoExpress for strain D39V: SPV_0643 PneumoExpress

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You can add further information about the gene and protein here. [edit]

⊟Literature

⊟References

⊟Relevant publications