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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae JJA
  • locus tag: SPJ_0954 [new locus tag: SPJ_RS04775 ]
  • pan locus tag?: PNEUPAN002099000
  • symbol: asd
  • pan gene symbol?: asd
  • synonym:
  • product: aspartate-semialdehyde dehydrogenase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPJ_0954 [new locus tag: SPJ_RS04775 ]
  • symbol: asd
  • product: aspartate-semialdehyde dehydrogenase
  • replicon: chromosome
  • strand: +
  • coordinates: 911918..912994
  • length: 1077
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    ATGGGATATACAGTTGCTGTAGTCGGCGCGACAGGTGCTGTCGGTGCTCAGATGATAAAA
    ATGTTGGAAGAATCAACACTTCCAATCGATAAAATCCGTTACCTTGCTTCTGCACGTTCA
    GCAGGTAAGTCATTGAAATTTAAAGATCAAGATATTACGATTGAAGAAACGACTGAAACA
    GCTTTTGAAGGAGTTGATATTGCTCTCTTTTCAGCAGGTGGTTCGACATCAGCTAAGTAT
    GCACCATACGCAGTAAAAGCTGGCGTGGTAGTAGTGGATAATACATCTTATTTCCGTCAA
    AATCCAGATGTTCCTTTGGTTGTTCCAGAGGTCAATGCTCATGCACTTGATGCCCACAAC
    GGAATCATTGCCTGCCCTAACTGTTCAACAATCCAAATGATGGTGGCTCTTGAGCCGGTT
    CGCCAAAAATGGGGCTTGGACCGTATCATTGTTTCAACTTATCAAGCCGTTTCAGGTGCT
    GGTATGGGAGCAATTCTTGAGACACAACGTGAACTTCGTGAGGTCTTGAATGATGGAGTG
    AAACCACGTGATTTGCATGCGGAAATCTTGCCTTCAGGTGGTGACAAGAAACATTATCCT
    ATCGCCTTTAACGCTCTTCCACAAATTGATGTCTTCACTGATAATGATTACACGTACGAA
    GAGATGAAGATGACCAAGGAAACTAAGAAAATTATGGAAGATGATAGCATTGCAGTATCT
    GCGACATGTGTGCGTATTCCAGTCTTGTCAGCTCACTCTGAGTCAGTTTATATTGAAACA
    AAGGAAGTGGCTCCAATTGAAGAAGTCAAAGCAGCTATCGCATCCTTCCCAGGTGCTGTT
    CTTGAAGATGATGTAGTTCATCAAATCTATCCTCAAGCCATCAATGCAGTTGGTTCACGT
    GATACCTTTGTTGGTCGTATCCGTAAAGACTTGGATGCAGAAAAAGGAATTCACATGTGG
    GTTGTTTCAGATAACCTTCTCAAAGGTGCTGCTTGGAACTCAGTTCAGATTGCTGAAACT
    CTTCATGAACGTGGATTGGTTCGTCCAACAGCTGAATTGAAATTTGAATTAAAATAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1077

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPJ_0954 [new locus tag: SPJ_RS04775 ]
  • symbol: Asd
  • description: aspartate-semialdehyde dehydrogenase
  • length: 358
  • theoretical pI: 4.9468
  • theoretical MW: 38991.3
  • GRAVY: -0.0645251

⊟Function[edit | edit source]

  • ⊞reaction:
    EC 1.2.1.11?  ExPASy
    Aspartate-semialdehyde dehydrogenase L-aspartate 4-semialdehyde + phosphate + NADP+ = L-4-aspartyl phosphate + NADPH
  • ⊞TIGRFAM:
    Metabolism Amino acid biosynthesis Aspartate family aspartate-semialdehyde dehydrogenase (TIGR01296; EC 1.2.1.11; HMM-score: 446.1)
    and 5 more
    Metabolism Amino acid biosynthesis Aspartate family aspartate-semialdehyde dehydrogenase (TIGR00978; EC 1.2.1.11; HMM-score: 146.7)
    Metabolism Amino acid biosynthesis Aspartate family aspartate-semialdehyde dehydrogenase (TIGR01745; EC 1.2.1.11; HMM-score: 83.3)
    Metabolism Amino acid biosynthesis Glutamate family N-acetyl-gamma-glutamyl-phosphate reductase (TIGR01850; EC 1.2.1.38; HMM-score: 59.5)
    Metabolism Energy metabolism Glycolysis/gluconeogenesis glyceraldehyde-3-phosphate dehydrogenase, type I (TIGR01534; EC 1.2.1.-; HMM-score: 14.8)
    Metabolism Central intermediary metabolism Other long-chain fatty acyl-ACP reductase (aldehyde-forming) (TIGR04058; EC 1.1.1.-; HMM-score: 14.1)
  • ⊞TheSEED  :
    • Aspartate-semialdehyde dehydrogenase (EC 1.2.1.11)
    Amino Acids and Derivatives Lysine, threonine, methionine, and cysteine Lysine Biosynthesis DAP Pathway  Aspartate-semialdehyde dehydrogenase (EC 1.2.1.11)
    and 1 more
    Amino Acids and Derivatives Lysine, threonine, methionine, and cysteine Threonine and Homoserine Biosynthesis  Aspartate-semialdehyde dehydrogenase (EC 1.2.1.11)
  • ⊞PFAM:
    GADPH_aa-bio_dh (CL0139) Semialdhyde_dhC; Semialdehyde dehydrogenase, dimerisation domain (PF02774; HMM-score: 180.8)
    and 5 more
    NADP_Rossmann (CL0063) Semialdhyde_dh; Semialdehyde dehydrogenase, NAD binding domain (PF01118; HMM-score: 109.8)
    DapB_N; Dihydrodipicolinate reductase, N-terminus (PF01113; HMM-score: 20.8)
    GADPH_aa-bio_dh (CL0139) Gp_dh_C; Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain (PF02800; HMM-score: 17.2)
    NADP_Rossmann (CL0063) NAD_binding_10; NAD(P)H-binding (PF13460; HMM-score: 16.8)
    Epimerase; NAD dependent epimerase/dehydratase family (PF01370; HMM-score: 13.1)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • ⊞PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • ⊞SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.030212
    • TAT(Tat/SPI): 0.001671
    • LIPO(Sec/SPII): 0.013621
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MGYTVAVVGATGAVGAQMIKMLEESTLPIDKIRYLASARSAGKSLKFKDQDITIEETTETAFEGVDIALFSAGGSTSAKYAPYAVKAGVVVVDNTSYFRQNPDVPLVVPEVNAHALDAHNGIIACPNCSTIQMMVALEPVRQKWGLDRIIVSTYQAVSGAGMGAILETQRELREVLNDGVKPRDLHAEILPSGGDKKHYPIAFNALPQIDVFTDNDYTYEEMKMTKETKKIMEDDSIAVSATCVRIPVLSAHSESVYIETKEVAPIEEVKAAIASFPGAVLEDDVVHQIYPQAINAVGSRDTFVGRIRKDLDAEKGIHMWVVSDNLLKGAAWNSVQIAETLHERGLVRPTAELKFELK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • ⊞regulator: CodY (repression) regulon

⊟Expression data[edit | edit source]

⊞Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊞Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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