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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 05-OCT-2017

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae MDRSPN001
  • locus tag: MDRSPN_01060 [new locus tag: MDRSPN_RS05570 ]
  • pan locus tag?: PNEUPAN001940000
  • symbol: tmk
  • pan gene symbol?: tmk
  • synonym:
  • product: thymidylate kinase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: MDRSPN_01060 [new locus tag: MDRSPN_RS05570 ]
  • symbol: tmk
  • product: thymidylate kinase
  • replicon: chromosome
  • strand: -
  • coordinates: 1075780..1076418
  • length: 639
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Location: AP018391 (1075780..1076418) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0825 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    ATGTCAAAAGGATTTTTAGTCTCTCTTGAGGGACCAGAGGGAGCAGGCAAGACCAGTGTT
    TTAGAGGCTCTACTCCCAATTTTAGAGGAAAAAGGAGTAGAGGTGCTGACGACCCGTGAG
    CCAGGCGGAGTCTTGATTGGGGAGAAGATTCGGGAAGTGATTTTGGATCCAAGTCATACT
    CAGATGGATCCTAAAACAGAACTCCTTCTCTATATTGCCAGTCGTAGACAGCATTTGGTG
    GAAAAAGTTCTCCCAGCACTTGACGCTGGTAAGTTGGTCATTATGGACCGCTTCATCGAT
    AGTTCCATTGCTTATCAGGGATTTGGCCGTGGCTTGGATATAGATGCCATTGACTGGCTC
    AATCAGTTTGCGACAGATGGCCTCAAACCTGATTTGACCCTTTATTTTGACATTGAGGTG
    GAAGAGGGACTGGCTCGCATTGCTGCTAATAGTGACCGTGAGGTCAATCGCTTGGACTTG
    GAAGGGTTGGACTTGCACAAAAAAGTTCGTCAAGGCTATCTTTCTCTTCTTGACAAAGAA
    GGAAATCGCATTGTCAAGATTGATGCCAGTCTCCCTTTGGAACAAGTTGTGGAAACTACC
    AAGGATATCTTGTTTGATAGAATGGGCTTGGCTAAATGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    639

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: MDRSPN_01060 [new locus tag: MDRSPN_RS05570 ]
  • symbol: Tmk
  • description: thymidylate kinase
  • length: 212
  • theoretical pI: 4.57279
  • theoretical MW: 23521.9
  • GRAVY: -0.0915094

⊟Function[edit | edit source]

  • ⊞TIGRFAM:
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Nucleotide and nucleoside interconversions dTMP kinase (TIGR00041; EC 2.7.4.9; HMM-score: 200.9)
    and 3 more
    Metabolism Transport and binding proteins Unknown substrate anchored repeat-type ABC transporter, ATP-binding subunit (TIGR03771; HMM-score: 18)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Molybdopterin molybdopterin-guanine dinucleotide biosynthesis protein B (TIGR00176; HMM-score: 15.9)
    thiol reductant ABC exporter, CydD subunit (TIGR02857; HMM-score: 12.1)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • ⊞PFAM:
    P-loop_NTPase (CL0023) Thymidylate_kin; Thymidylate kinase (PF02223; HMM-score: 179.9)
    and 9 more
    AAA_28; AAA domain (PF13521; HMM-score: 23.1)
    AAA_16; AAA ATPase domain (PF13191; HMM-score: 17.4)
    AAA_30; AAA domain (PF13604; HMM-score: 16.2)
    MobB; Molybdopterin guanine dinucleotide synthesis protein B (PF03205; HMM-score: 15.2)
    AAA_33; AAA domain (PF13671; HMM-score: 15)
    dNK; Deoxynucleoside kinase (PF01712; HMM-score: 14.6)
    AAA_18; AAA domain (PF13238; HMM-score: 13.9)
    ABC_tran; ABC transporter (PF00005; HMM-score: 13.4)
    AAA_29; P-loop containing region of AAA domain (PF13555; HMM-score: 11.4)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • ⊞PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • ⊞SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.002782
    • TAT(Tat/SPI): 0.000265
    • LIPO(Sec/SPII): 0.000397
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: BBA59263 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MSKGFLVSLEGPEGAGKTSVLEALLPILEEKGVEVLTTREPGGVLIGEKIREVILDPSHTQMDPKTELLLYIASRRQHLVEKVLPALDAGKLVIMDRFIDSSIAYQGFGRGLDIDAIDWLNQFATDGLKPDLTLYFDIEVEEGLARIAANSDREVNRLDLEGLDLHKKVRQGYLSLLDKEGNRIVKIDASLPLEQVVETTKDILFDRMGLAK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊞Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊞Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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