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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 15-OCT-2021

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae P1031
  • locus tag: SPP_RS10075 [old locus tag: SPP_2044 ]
  • pan locus tag?: PNEUPAN000297000
  • symbol: SPP_RS10075
  • pan gene symbol?: comX1
  • synonym:
  • product: sigma-70 family RNA polymerase sigma factor

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPP_RS10075 [old locus tag: SPP_2044 ]
  • symbol: SPP_RS10075
  • product: sigma-70 family RNA polymerase sigma factor
  • replicon: chromosome
  • strand: -
  • coordinates: 1870856..1871335
  • length: 480
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_012467 (1870856..1871335) NCBI
  • BioCyc: SPP_RS10075 BioCyc
  • MicrobesOnline: see SPP_2044
  • PneumoBrowse for strain D39V: SPV_0014 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    ATGATTAAAGAATTGTATGAAGAAGTCCAAGGGACTGTTTATAAGTGTAGAAATGAATAT
    TACCTTCATTTATGGGAATTGTCGGATTGGGACCAAGAAGGCATGCTCTGCTTACATGAA
    TTGATTAGTAGAGAAGAAGGACTGGTAGACGATATTCCACGTTTAAGGAAATATTTCAAA
    ACCAAGTTTCGAAATCGAATTTTAGACTATATCCGTAAGCAGGAAAGTCAGAAGCGTAGA
    TACGATAAAGAACCCTATGAAGAAGTGGGAGAGATCAGTCATCGTATAAGTGAGGGGGGT
    CTCTGGCTAGATGATTATTATCTCTTTCATGAAACACTAAGAGATTATAGAAACAAACAA
    AGTAAAGAGAAACAAGAAGAACTAGAACGCGTCTTAAGCAATGAACGATTTCGAGGGCGT
    CAAAGAGTATTAAGAGACTTACGCATTGTGTTTAAGGAGTTTACTATCCGTACCCACTAG
    60
    120
    180
    240
    300
    360
    420
    480

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPP_RS10075 [old locus tag: SPP_2044 ]
  • symbol: SPP_RS10075
  • description: sigma-70 family RNA polymerase sigma factor
  • length: 159
  • theoretical pI: 7.61287
  • theoretical MW: 19873.4
  • GRAVY: -1.07862

⊟Function[edit | edit source]

  • ⊞TIGRFAM:
    RNA polymerase sigma factor, sigma-70 family (TIGR02937; HMM-score: 32.6)
    and 1 more
    RNA polymerase sigma-70 factor, Bacteroides expansion family 1 (TIGR02985; HMM-score: 13.6)
  • TheSEED: see SPP_2044
  • PFAM:
    HTH (CL0123) Sigma70_r2; Sigma-70 region 2 (PF04542; HMM-score: 15.7)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:
  • genes regulated by ComX1, sigma factor, controls the expression of late competence genes: in D39, TIGR4

⊟Localization[edit | edit source]

  • ⊞PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • ⊞SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.003025
    • TAT(Tat/SPI): 0.000204
    • LIPO(Sec/SPII): 0.000824
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000588897 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MIKELYEEVQGTVYKCRNEYYLHLWELSDWDQEGMLCLHELISREEGLVDDIPRLRKYFKTKFRNRILDYIRKQESQKRRYDKEPYEEVGEISHRISEGGLWLDDYYLFHETLRDYRNKQSKEKQEELERVLSNERFRGRQRVLRDLRIVFKEFTIRTH

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊞Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊞Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

M S Lee, D A Morrison
Identification of a new regulator in Streptococcus pneumoniae linking quorum sensing to competence for genetic transformation.
J Bacteriol: 1999, 181(16);5004-16
[PubMed:10438773] [WorldCat.org] [DOI] (P p)

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