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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 30-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae R6
  • locus tag: spr1444 [new locus tag: SPR_RS07180 ]
  • pan locus tag?: PNEUPAN002973000
  • symbol: cobQ
  • pan gene symbol?: gatD
  • synonym:
  • product: Cobyric acid synthase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: spr1444 [new locus tag: SPR_RS07180 ]
  • symbol: cobQ
  • product: Cobyric acid synthase
  • replicon: chromosome
  • strand: +
  • coordinates: 1429735..1430517
  • length: 783
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    ATGGTTTATACTTCACTTTCCTCAAAAGATGGCAATTACCCCTATCAGCTCAACATTGCC
    CACCTCTACGGAAATCTCATGAATACCTACGGGGACAATGGAAACATCCTCATGCTCAAG
    TATGTGGCTGAAAAACTGGGAGCCCATGTGACCGTTGACATCGTTTCTCTCCATGATGAC
    TTTGATGAAAATCACTACGACATCGCCTTTTTCGGTGGTGGTCAAGACTTTGAACAAAGT
    ATCATTGCAGACGACCTACCTGCTAAAAAAGAGAGCATTGACAACTACATCCAAAACGAC
    GGTGTAGTTCTGGCTATCTGCGGTGGTTTCCAACTATTGGGTCAATATTATGTTGAAGCT
    TCAGGAAAACGTATCGAAGGGCTAGGGGTCATGGGACACTACACGCTCAACCAGACCAAT
    AACCGTTTTATCGGTGACATCAAGATTCACAATGAAGATTTCGATGAAACCTACTATGGA
    TTTGAAAATCACCAAGGCCGTACCTTCCTCTCTGATGACCAAAAACCGCTGGGACAGGTT
    GTCTATGGAAATGGAAACAACGAAGAAAAGGTCGGTGAAGGGGTTCATTATAAGAATGTC
    TTTGGTTCCTACTTCCACGGGCCTATCCTCTCTCGTAATGCCAATCTGGCTTATCGCCTA
    GTTACTACTGCCCTCAAGAAGAAATATGGTCAGGACATCCAACTCCCTGCCTATGAGGAT
    ATCCTCAGCCAAGAAATCGCTGAAGAGTACAGTGACGTCAAAAGCAAGGCTGACTTTTCT
    TAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    783

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: spr1444 [new locus tag: SPR_RS07180 ]
  • symbol: CobQ
  • description: Cobyric acid synthase
  • length: 260
  • theoretical pI: 4.55216
  • theoretical MW: 29193.1
  • GRAVY: -0.465

⊟Function[edit | edit source]

  • ⊞TIGRFAM:
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Heme, porphyrin, and cobalamin cobyric acid synthase CobQ (TIGR00313; EC 6.3.5.10; HMM-score: 58.3)
    and 3 more
    Metabolism Amino acid biosynthesis Histidine family imidazole glycerol phosphate synthase, glutamine amidotransferase subunit (TIGR01855; EC 2.4.2.-; HMM-score: 19.6)
    Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides intracellular protease, PfpI family (TIGR01382; HMM-score: 17.6)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Purine ribonucleotide biosynthesis phosphoribosylformylglycinamidine synthase I (TIGR01737; EC 6.3.5.3; HMM-score: 16.2)
  • TheSEED  :
    • Lipid II isoglutaminyl synthase (glutamine-hydrolyzing), GatD subunit (EC 6.3.5.13)
  • ⊞PFAM:
    Glutaminase_I (CL0014) GATase_3; CobB/CobQ-like glutamine amidotransferase domain (PF07685; HMM-score: 160.5)
    and 4 more
    DJ-1_PfpI; DJ-1/PfpI family (PF01965; HMM-score: 16.8)
    GATase; Glutamine amidotransferase class-I (PF00117; HMM-score: 16)
    Acetyltrans (CL0257) Acetyltransf_18; Acetyltransferase (GNAT) domain (PF18014; HMM-score: 15.1)
    Glutaminase_I (CL0014) GATase_5; CobB/CobQ-like glutamine amidotransferase domain (PF13507; HMM-score: 14.5)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • ⊞PSORTb: unknown (no significant prediction)
    • Cytoplasmic Score: 2.5
    • Cytoplasmic Membrane Score: 2.5
    • Cellwall Score: 2.5
    • Extracellular Score: 2.5
    • Internal Helices: 0
  • ⊞SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.007403
    • TAT(Tat/SPI): 0.000096
    • LIPO(Sec/SPII): 0.000454
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MVYTSLSSKDGNYPYQLNIAHLYGNLMNTYGDNGNILMLKYVAEKLGAHVTVDIVSLHDDFDENHYDIAFFGGGQDFEQSIIADDLPAKKESIDNYIQNDGVVLAICGGFQLLGQYYVEASGKRIEGLGVMGHYTLNQTNNRFIGDIKIHNEDFDETYYGFENHQGRTFLSDDQKPLGQVVYGNGNNEEKVGEGVHYKNVFGSYFHGPILSRNANLAYRLVTTALKKKYGQDIQLPAYEDILSQEIAEEYSDVKSKADFS

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊞Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊞Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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