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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 15-OCT-2021

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae 670-6B
  • locus tag: SP670_RS11145 [old locus tag: SP670_2204 ]
  • pan locus tag?: PNEUPAN003800000
  • symbol: SP670_RS11145
  • pan gene symbol?: gph_3
  • synonym:
  • product: HAD family hydrolase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SP670_RS11145 [old locus tag: SP670_2204 ]
  • symbol: SP670_RS11145
  • product: HAD family hydrolase
  • replicon: chromosome
  • strand: -
  • coordinates: 2042823..2043443
  • length: 621
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_014498 (2042823..2043443) NCBI
  • BioCyc: SP670_RS11145 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1875 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    ATGCAAAAAACAGCTTTTATTTGGGATTTAGACGGGACTTTATTGGACTCTTACGAAGCG
    ATTTTATCAGGGATTGAGGAGACTTTTGCTCAGTTTTCTATTCCTTATGATAAGGAGAAG
    GTGAGAGAGTTTATCTTCAAGTATTCGGTGCAAGATTTGCTTGTGCGGGTGGCAGAAGAT
    AGAAATCTGGATGTTGAGGTGCTAAATCAGGTGCGTGCCCAGAGTCTGGCTGAGAAGAAT
    GCTCAGGTAGTTTTGATGCCAGGTGCGCGTGAGGTGCTAGCTTGGGCAGACGAATCAGGA
    ATTCAGCAGTTTATATATACTCATAAGGGGAACAACGCTTTTACCATTCTCAAGGACTTG
    GGGGTGGAATCCTATTTTACAGAGATTTTAACCAGTCAGAGTGGCTTTGTGCGGAAGCCA
    AGTCCAGAAGCGGCTACCTATCTGCTAGATAAGTATCAGTTGAATTCTGATAATACTTAT
    TATATAGGGGATCGGACTCTGGATGTGGAATTTGCCCAGAATAGTGGGATTCAAAGCATC
    AACTTTTTAGAGTCTACTTATGAAGGGAATCACAGGATTCAAGCGTTAGCAGATATTTCC
    CGTATTTTTGAGACTAAGTGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    621

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SP670_RS11145 [old locus tag: SP670_2204 ]
  • symbol: SP670_RS11145
  • description: HAD family hydrolase
  • length: 206
  • theoretical pI: 4.34502
  • theoretical MW: 23490.1
  • GRAVY: -0.272816

⊟Function[edit | edit source]

  • ⊞TIGRFAM:
    Metabolism Energy metabolism Sugars phosphoglycolate phosphatase, bacterial (TIGR01449; EC 3.1.3.18; HMM-score: 50.9)
    HAD hydrolase, TIGR02253 family (TIGR02253; HMM-score: 50.1)
    Unknown function Enzymes of unknown specificity HAD hydrolase, family IA, variant 1 (TIGR01549; HMM-score: 45.4)
    noncanonical pyrimidine nucleotidase, YjjG family (TIGR02254; EC 3.1.3.5; HMM-score: 44.8)
    beta-phosphoglucomutase family hydrolase (TIGR02009; HMM-score: 43.4)
    and 18 more
    HAD hydrolase, REG-2-like, family IA (TIGR02252; HMM-score: 39.3)
    Unknown function Enzymes of unknown specificity HAD hydrolase, family IIIA (TIGR01662; HMM-score: 37.7)
    AHBA synthesis associated protein (TIGR01454; HMM-score: 36.6)
    Metabolism Energy metabolism Biosynthesis and degradation of polysaccharides beta-phosphoglucomutase (TIGR01990; EC 5.4.2.6; HMM-score: 32.1)
    Unknown function Enzymes of unknown specificity HAD hydrolase, family IA, variant 3 (TIGR01509; HMM-score: 25.8)
    Metabolism Amino acid biosynthesis Histidine family histidinol-phosphatase (TIGR01261; EC 3.1.3.15; HMM-score: 25.5)
    Unknown function Enzymes of unknown specificity HAD hydrolase, family IIA (TIGR01460; HMM-score: 24.3)
    histidinol-phosphate phosphatase domain (TIGR01656; HMM-score: 24.2)
    Unknown function Enzymes of unknown specificity Cof-like hydrolase (TIGR00099; HMM-score: 21.1)
    phosphonatase-like hydrolase (TIGR03351; HMM-score: 21)
    pyrimidine 5'-nucleotidase (TIGR01993; EC 3.1.3.5; HMM-score: 20.9)
    haloacid dehalogenase, type II (TIGR01428; EC 3.8.1.2; HMM-score: 20.3)
    phosphoglycolate/pyridoxal phosphate phosphatase family (TIGR01452; EC 3.1.3.18; HMM-score: 19.6)
    DNA 3'-phosphatase (TIGR01664; EC 3.1.3.32; HMM-score: 18)
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family (TIGR01670; EC 3.1.3.45; HMM-score: 17.7)
    Unknown function Enzymes of unknown specificity HAD phosphoserine phosphatase-like hydrolase, family IB (TIGR01488; HMM-score: 16.6)
    epoxide hydrolase N-terminal domain-like phosphatase (TIGR02247; HMM-score: 13.5)
    Unknown function Enzymes of unknown specificity HAD hydrolase, family IIB (TIGR01484; HMM-score: 12.6)
  • TheSEED: see SP670_2204
  • ⊞PFAM:
    HAD (CL0137) HAD_2; haloacid dehalogenase-like hydrolase (PF13419; HMM-score: 102.5)
    and 8 more
    Hydrolase; haloacid dehalogenase-like hydrolase (PF00702; HMM-score: 46.2)
    HAD; haloacid dehalogenase-like hydrolase (PF12710; HMM-score: 41.6)
    Hydrolase_like; HAD-hyrolase-like (PF13242; HMM-score: 32.8)
    Hydrolase_3; haloacid dehalogenase-like hydrolase (PF08282; HMM-score: 23.3)
    PNK3P; Polynucleotide kinase 3 phosphatase (PF08645; HMM-score: 16.6)
    Hydrolase_6; haloacid dehalogenase-like hydrolase (PF13344; HMM-score: 15)
    S6PP; Sucrose-6F-phosphate phosphohydrolase (PF05116; HMM-score: 14.8)
    no clan defined DUF2789; Protein of unknown function (DUF2789) (PF10982; HMM-score: 12.7)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • ⊞PSORTb: unknown (no significant prediction)
    • Cytoplasmic Score: 2.5
    • Cytoplasmic Membrane Score: 2.5
    • Cellwall Score: 2.5
    • Extracellular Score: 2.5
    • Internal Helices: 0
  • ⊞SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.00206
    • TAT(Tat/SPI): 0.000132
    • LIPO(Sec/SPII): 0.00029
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_001172823 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MQKTAFIWDLDGTLLDSYEAILSGIEETFAQFSIPYDKEKVREFIFKYSVQDLLVRVAEDRNLDVEVLNQVRAQSLAEKNAQVVLMPGAREVLAWADESGIQQFIYTHKGNNAFTILKDLGVESYFTEILTSQSGFVRKPSPEAATYLLDKYQLNSDNTYYIGDRTLDVEFAQNSGIQSINFLESTYEGNHRIQALADISRIFETK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊞Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊞Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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