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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 17-JAN-2018

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae AP200
  • locus tag: SPAP_0848 [new locus tag: SPAP_RS04210 ]
  • pan locus tag?: PNEUPAN001858000
  • symbol: SPAP_0848
  • pan gene symbol?: fruR
  • synonym:
  • product: Transcriptional regulators of sugar metabolism

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPAP_0848 [new locus tag: SPAP_RS04210 ]
  • symbol: SPAP_0848
  • product: Transcriptional regulators of sugar metabolism
  • replicon: chromosome
  • strand: +
  • coordinates: 802254..802994
  • length: 741
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    GTGTTAAAAACAGAACGTAAACAACTGATTCTAGAGGAGTTAAATCAACATCATGTAGTT
    TCTCTAGAAAAATTAGTTAGTTTGCTAGAAACGTCAGAATCAACGGTTCGAAGAGACTTG
    GATGAGTTGGAAGCGGAAAACAAGCTTCGTCGTGTGCATGGTGGAGCAGAACTCCCCCAC
    TCCTTACAGGAAGAAGAAACCATTCAAGAAAAATCTGTCAAAAACCTTCAAGAAAAGAAG
    TTGCTGGCTCAGAAAGCAGCCTCTCTCATTAAAGAAAAAGATGTCATCTTTATCGATGCT
    GGAACAACAACTGCTTTTTTGATTCATGAATTGGTCAATAAGAATGTTACAGTTGTGACC
    AACTCCATTCACCATGCCGCTCAGTTGGTTGAAAAGCAGATTCCAACTGTCATGGTTGGA
    GGAAACGTCAAGACGGCGACAGATGCTAGTATCGGGGGCGTTGCTCTTAACCAGATTAAC
    CAATTGCACTTTGACCGTGCCTTTATCGGAATGAATGGTGTTGACGATGGCTATTATACG
    ACTCCTGATATGGAGGAGGGAGCTGTGAAAAGAGCTATTTTGGAGAATGCCAAGCAGACC
    TACGTCTTGGTGGATTCGTCAAAAATTGGACAAACTTGCTTTGCCAAGGTAGCACCACTC
    AAACGCGCTATCGTTATCACTAGTCAAGGGCATGAGCTCTTGCAGGTTATTAAGGAGAAA
    ACGGAGGTAATAGAAGTATGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    741

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPAP_0848 [new locus tag: SPAP_RS04210 ]
  • symbol: SPAP_0848
  • description: Transcriptional regulators of sugar metabolism
  • length: 246
  • theoretical pI: 6.2447
  • theoretical MW: 27277.1
  • GRAVY: -0.211382

⊟Function[edit | edit source]

  • ⊞TIGRFAM:
    Metabolism Energy metabolism Pentose phosphate pathway ribose 5-phosphate isomerase A (TIGR00021; EC 5.3.1.6; HMM-score: 19.3)
    and 1 more
    Signal transduction Regulatory functions DNA interactions CRISPR locus-related DNA-binding protein (TIGR01884; HMM-score: 10.4)
  • TheSEED  :
    • Transcriptional repressor of the fructose operon, DeoR family
    Carbohydrates Monosaccharides Fructose utilization  Transcriptional repressor of the fructose operon, DeoR family
  • ⊞PFAM:
    ISOCOT_Fold (CL0246) DeoRC; DeoR C terminal sensor domain (PF00455; HMM-score: 173)
    and 13 more
    HTH (CL0123) HTH_DeoR; DeoR-like helix-turn-helix domain (PF08220; HMM-score: 67.7)
    HTH_11; HTH domain (PF08279; HMM-score: 25.8)
    GntR; Bacterial regulatory proteins, gntR family (PF00392; HMM-score: 21.4)
    no clan defined DUF3972; Protein of unknown function (DUF3972) (PF13118; HMM-score: 18.8)
    HTH (CL0123) MarR; MarR family (PF01047; HMM-score: 16.4)
    NADP_Rossmann (CL0063) Shikimate_DH; Shikimate / quinate 5-dehydrogenase (PF01488; HMM-score: 16.2)
    no clan defined DUF2777; Protein of unknown function (DUF2777) (PF10949; HMM-score: 14.5)
    FIMP; Fertilisation-influencing membrane protein (PF17672; HMM-score: 14)
    Nitro_FeMo-Co; Dinitrogenase iron-molybdenum cofactor (PF02579; HMM-score: 13.6)
    Toprim-like (CL0413) DUF3854; Domain of unknown function (DUF3854) (PF12965; HMM-score: 13.4)
    HTH (CL0123) DUF5805; Family of unknown function (DUF5805) (PF19121; HMM-score: 13.1)
    Arg_repressor; Arginine repressor, DNA binding domain (PF01316; HMM-score: 10.9)
    no clan defined Stk19; Serine-threonine protein kinase 19 (PF10494; HMM-score: 10.5)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:
  • genes regulated by FruR*, TF important in Fructose utilization: in TIGR4

⊟Localization[edit | edit source]

  • ⊞PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • ⊞SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.003872
    • TAT(Tat/SPI): 0.000382
    • LIPO(Sec/SPII): 0.000235
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: ADM84437 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MLKTERKQLILEELNQHHVVSLEKLVSLLETSESTVRRDLDELEAENKLRRVHGGAELPHSLQEEETIQEKSVKNLQEKKLLAQKAASLIKEKDVIFIDAGTTTAFLIHELVNKNVTVVTNSIHHAAQLVEKQIPTVMVGGNVKTATDASIGGVALNQINQLHFDRAFIGMNGVDDGYYTTPDMEEGAVKRAILENAKQTYVLVDSSKIGQTCFAKVAPLKRAIVITSQGHELLQVIKEKTEVIEV

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊞Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊞Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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