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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 07-MAR-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae Hu17
  • locus tag: SPNHU17_RS00315 [old locus tag: SPNHU17_00062 ]
  • pan locus tag?: PNEUPAN000186000
  • symbol: SPNHU17_RS00315
  • pan gene symbol?: hol
  • synonym:
  • product: phage holin

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPNHU17_RS00315 [old locus tag: SPNHU17_00062 ]
  • symbol: SPNHU17_RS00315
  • product: phage holin
  • replicon: chromosome
  • strand: +
  • coordinates: 53330..53662
  • length: 333
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_CP020549 (53330..53662) NCBI
  • BioCyc: SPNHU17_RS00315 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    ATGCAACAAATTACTGAAATCATTACTAATGGAGCAATCAGCATCCTAGTCATTTTAGCA
    GGGGTGGTAGTTAGGGCAGTCAAGGATTACCTGGTTCAAAAAGGTGGAGAAAAGACCATC
    AAAATCGTTGAAATCTTGGCCAAGAACGCAGTAAATGCCGTTGAGCAGGTTGCCTCAGAG
    ACTGGCTTTAAAGGCGAAGAAAAGCTGGAGCAGGCTCGTGCTAAAGTCCGTGCTGAGCTT
    ACAAAATACAATATTAGCATGACTGACAAAGACTTAGACACCTTCGTAGAGTCAGCAGTG
    AAGCAGATGAATGACGCATGGAAAGGACGATAG
    60
    120
    180
    240
    300
    333

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPNHU17_RS00315 [old locus tag: SPNHU17_00062 ]
  • symbol: SPNHU17_RS00315
  • description: phage holin
  • length: 110
  • theoretical pI: 8.95723
  • theoretical MW: 12108
  • GRAVY: -0.100909

⊟Function[edit | edit source]

  • ⊞TIGRFAM:
    Genetic information processing Mobile and extrachromosomal element functions Prophage functions phage holin, LL-H family (TIGR01673; HMM-score: 57.4)
    and 1 more
    Cellular processes Cellular processes Toxin production and resistance circular bacteriocin, circularin A/uberolysin family (TIGR03651; HMM-score: 11.6)
  • TheSEED: data available for Hungary19A-6
  • ⊞PFAM:
    no clan defined Phage_holin_6_1; Bacteriophage holin of superfamily 6 (Holin_LLH) (PF09682; HMM-score: 99.1)
    and 4 more
    Oxa1 (CL0376) EMC3_TMCO1; Integral membrane protein EMC3/TMCO1-like (PF01956; HMM-score: 13.9)
    no clan defined ANAPC4; Anaphase-promoting complex, cyclosome, subunit 4 (PF12896; HMM-score: 12.3)
    Mis12; Mis12 protein (PF05859; HMM-score: 12.2)
    DUF2232; Predicted membrane protein (DUF2232) (PF09991; HMM-score: 11.9)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • ⊞PSORTb: unknown (no significant prediction)
    • Cytoplasmic Score: 2.5
    • Cytoplasmic Membrane Score: 2.5
    • Cellwall Score: 2.5
    • Extracellular Score: 2.5
    • Internal Helices: 0
  • ⊞DeepLocPro: Cytoplasmic Membrane
    • Cytoplasmic Score: 0.0007
    • Cytoplasmic Membrane Score: 0.92
    • Cell wall & surface Score: 0.0025
    • Extracellular Score: 0.0769
  • ⊞SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.237806
    • TAT(Tat/SPI): 0.002236
    • LIPO(Sec/SPII): 0.009143
  • predicted transmembrane helices (TMHMM): 1

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_001186229 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MQQITEIITNGAISILVILAGVVVRAVKDYLVQKGGEKTIKIVEILAKNAVNAVEQVASETGFKGEEKLEQARAKVRAELTKYNISMTDKDLDTFVESAVKQMNDAWKGR

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

  • PneumoExpress for strain D39V:

⊞Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊞Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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