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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 25-OCT-2024

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⊟Summary[edit | edit source]

Contents

  • 1 Summary
  • 2 Genome View
  • 3 Gene
    • 3.1 General
    • 3.2 Accession numbers
    • 3.3 Phenotype
    • 3.4 DNA sequence
  • 4 Protein
    • 4.1 General
    • 4.2 Function
    • 4.3 Structure, modifications & cofactors
    • 4.4 Localization
    • 4.5 Accession numbers
    • 4.6 Protein sequence
    • 4.7 Experimental data
  • 5 Expression & Regulation
    • 5.1 Operon
    • 5.2 Regulation
    • 5.3 Expression data
  • 6 Biological Material
    • 6.1 Mutants
    • 6.2 Expression vector
    • 6.3 lacZ fusion
    • 6.4 GFP fusion
    • 6.5 two-hybrid system
    • 6.6 FLAG-tag construct
    • 6.7 Antibody
  • 7 Other Information
  • 8 Literature
    • 8.1 References
    • 8.2 Relevant publications
  • organism: Streptococcus pneumoniae TCH8431/19A
  • locus tag: HMPREF0837_RS02015 [old locus tag: HMPREF0837_10401 ]
  • pan locus tag?: PNEUPAN000796000
  • symbol: HMPREF0837_RS02015
  • pan gene symbol?: apbA
  • synonym:
  • product: ABC transporter substrate-binding protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: HMPREF0837_RS02015 [old locus tag: HMPREF0837_10401 ]
  • symbol: HMPREF0837_RS02015
  • product: ABC transporter substrate-binding protein
  • replicon: chromosome
  • strand: +
  • coordinates: 374827..375633
  • length: 807
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_014251 (374827..375633) NCBI
  • BioCyc: HMPREF0837_RS02015 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0109 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    ATGAATAAGATGAAGAAGGTGTTGATGACGATGTTTGGTTTAGTGATGCTCCCCCTACTA
    TTTGCTTGTAGTAACAATCAATCGGCTGGAATTGAAGCCATCAAGTCCAAAGGAAAATTG
    GTTGTAGCCCTCAATCCAGATTTTGCTCCATTTGAATATCAAAAAGTGGTTGATGGGAAA
    AATCAGATTGTGGGTTCAGATATCGAATTAGCCAAGGCTATCGCAACAGAACTAGGTGTC
    GAATTGGAACTATCTCCTATGAGTTTTGACAATGTACTGGCTAGCGTTCAATCAGGAAAA
    GCTGACCTTGCCATATCAGGTGTTTCTAAGACAGATGAACGGAGCAAGGTGTTTGATTTT
    TCAACTCCCTACTATACTGCAAAAAATAAACTCATTGTCAAAAAATCTGATTTAGCCACT
    TATCAGTCTGTCAACGATTTGGCGCAGAAAAAGGTCGGAGCGCAGAAAGGTTCGATTCAA
    GAGACGATGGCGAAAGATTTGCTACAAAATTCTTCCCTCGTATCTCTGCCTAAAAATGGG
    AATTTAATCACAGATTTAAAATCAGGGCAAGTGGATGCCGTTATTTTTGAAGAACCCGTT
    GCCAAGGGATTTGTGGAAAATAATCCTGATTTAGCAATCGCAGACCTCAATTTTGAAAAA
    GAGCAAGATGATTCCTATGCGGTAGCCATGAAAAAAGATAGCAAGGAATTGAAAGAGGCA
    GTCGATAAAACCATTCAAAAGTTGAAGGAGTCTGGGGAATTAGACAAACTCATTGAGGAT
    GCCTTTAAAGCGTCCATTGAAAAATAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    807

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: HMPREF0837_RS02015 [old locus tag: HMPREF0837_10401 ]
  • symbol: HMPREF0837_RS02015
  • description: ABC transporter substrate-binding protein
  • length: 268
  • theoretical pI: 4.95365
  • theoretical MW: 29208.4
  • GRAVY: -0.219776

⊟Function[edit | edit source]

  • ⊞TIGRFAM:
    Metabolism Transport and binding proteins Amino acids, peptides and amines lysine-arginine-ornithine-binding periplasmic protein (TIGR01096; HMM-score: 155.8)
    and 6 more
    Metabolism Transport and binding proteins Amino acids, peptides and amines ectoine/hydroxyectoine ABC transporter solute-binding protein EhuB (TIGR02995; HMM-score: 74.9)
    extracellular substrate-binding orphan protein, GRRM family (TIGR04262; HMM-score: 45.8)
    quinoprotein dehydrogenase-associated probable ABC transporter substrate-binding protein (TIGR03871; HMM-score: 39.8)
    Metabolism Transport and binding proteins Other ABC transporter, substrate-binding protein, aliphatic sulfonates family (TIGR01728; HMM-score: 24.1)
    Metabolism Amino acid biosynthesis Histidine family ATP phosphoribosyltransferase (TIGR00070; EC 2.4.2.17; HMM-score: 13)
    Hypothetical proteins Conserved conserved hypothetical protein (TIGR02285; HMM-score: 12.3)
  • TheSEED: see HMPREF0837_10401
  • ⊞PFAM:
    PBP (CL0177) SBP_bac_3; Bacterial extracellular solute-binding proteins, family 3 (PF00497; HMM-score: 204.4)
    and 5 more
    Lig_chan-Glu_bd; Ligated ion channel L-glutamate- and glycine-binding site (PF10613; HMM-score: 31.5)
    NMT1; NMT1/THI5 like (PF09084; HMM-score: 26)
    no clan defined PMC2NT; PMC2NT (NUC016) domain (PF08066; HMM-score: 15.8)
    PBP (CL0177) LysR_substrate; LysR substrate binding domain (PF03466; HMM-score: 13)
    PBP_like; PBP superfamily domain (PF12727; HMM-score: 11.5)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • ⊞PSORTb: unknown (no significant prediction)
    • Cytoplasmic Score: 2.5
    • Cytoplasmic Membrane Score: 2.5
    • Cellwall Score: 2.5
    • Extracellular Score: 2.5
    • Internal Helices: 0
  • ⊞SignalP: Signal peptide LIPO(Sec/SPII) length 22 aa
    • SP(Sec/SPI): 0.002989
    • TAT(Tat/SPI): 0.000081
    • LIPO(Sec/SPII): 0.996676
    • Cleavage Site: CS pos: 22-23. LFA-CS. Pr: 0.9972
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_001038474 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MNKMKKVLMTMFGLVMLPLLFACSNNQSAGIEAIKSKGKLVVALNPDFAPFEYQKVVDGKNQIVGSDIELAKAIATELGVELELSPMSFDNVLASVQSGKADLAISGVSKTDERSKVFDFSTPYYTAKNKLIVKKSDLATYQSVNDLAQKKVGAQKGSIQETMAKDLLQNSSLVSLPKNGNLITDLKSGQVDAVIFEEPVAKGFVENNPDLAIADLNFEKEQDDSYAVAMKKDSKELKEAVDKTIQKLKESGELDKLIEDAFKASIEK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • data available for TIGR4

⊟Expression data[edit | edit source]

  • PneumoExpress for strain D39V: SPV_0109 PneumoExpress

⊞Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊞Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Retrieved from "http://pneumowiki.med.uni-greifswald.de/index.php?title=HMPREF0837_RS02015&oldid=167439"
  • This page was last edited on 20 January 2022, at 19:33.
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