⊟Summary[edit | edit source]

PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BM6001

serotype 19F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7465

serotype 1

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 11-FEB-2025

⊟Summary

• organism: Streptococcus pneumoniae INV200
locus tag: SPNINV200_RS10835 [old locus tag: SPNINV200_20020 ]
pan locus tag^?: PNEUPAN003901000
symbol: rr06
pan gene symbol^?: rr06
• synonym:
• product: two-component system response regulator RR06

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SPNINV200_RS10835 [old locus tag: SPNINV200_20020 ]
• symbol: rr06
• product: two-component system response regulator RR06
• replicon: chromosome
• strand: -
• coordinates: 2046610..2047263
• length: 654
• essential: unknown

⊟Accession numbers

• Location: NC_017593 (2046610..2047263) NCBI
• BioCyc: SPNINV200_RS10835 BioCyc
• MicrobesOnline:
• PneumoBrowse for strain D39V: SPV_2020 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  541
  601
  
  ATGAACATTTTAGTTGCAGATGACGAGGAAATGATTAGAGAAGGAATTGCAGCATTTCTG
  ACAGAAGAGGGTTATCATGTCATTATGGCTAAGGATGGACAAGAGGTCTTGGAAAAATTT
  CAAGATCTCCCTATCCATCTCATGGTATTGGATTTAATGATGCCTAGGAAGAGTGGTTTT
  GAAGTGTTAAAAGAAATCAATCAAAAGCACGATATTCCTGTCATCGTCTTGAGTGCTCTG
  GGAGATGAAACTACTCAGTCACAGGTATTTGATCTCTATGCTGATGATCATGTGACAAAA
  CCTTTTTCTTTGGTACTGCTTGTCAAGCGTATTAAGGCGCTTATCAGACGTTACTACGTC
  ATAGAGGATATTTGGCGATATCAGGATGTAACAGTGGATTTTACCTCTTACAAAGCACAT
  TATAAAAATGAAGAAATTGATCTCAAACCAAAGGAATTACTGGTACTAAAGTGTTTGATT
  CAGCATAAAAATCAAGTTTTAAGTAGAGAGCAGATATTGGAAGAAATTTCAAAAGATGTA
  GCTGATTTACCTTGTGATAGGGTCGTTGATGTCTATATTCGTACTCTTCGCAAAAAATTA
  GCTTTAGATTGTATCGTGACTGTGAAAAATGTTGGGTATAAGATTAGCTTATGA
  60
  120
  180
  240
  300
  360
  420
  480
  540
  600
  654
  

⊟Protein

⊟General

• locus tag: SPNINV200_RS10835 [old locus tag: SPNINV200_20020 ]
• symbol: Rr06
• description: two-component system response regulator RR06
• length: 217
• theoretical pI: 5.39129
• theoretical MW: 25204.3
• GRAVY: -0.0529954

⊟Function

• ⊞⊞TIGRFAM:
  Signal transduction Regulatory functions DNA interactions phosphate regulon transcriptional regulatory protein PhoB (TIGR02154; HMM-score: 155.7)
  Signal transduction Signal transduction Two-component systems phosphate regulon transcriptional regulatory protein PhoB (TIGR02154; HMM-score: 155.7)
  and 8 more
  Signal transduction Regulatory functions DNA interactions heavy metal response regulator (TIGR01387; HMM-score: 112.9)
  proteobacterial dedicated sortase system response regulator (TIGR03787; HMM-score: 82.4)
  Cellular processes Cellular processes Sporulation and germination sporulation transcription factor Spo0A (TIGR02875; HMM-score: 60.7)
  Metabolism Central intermediary metabolism Nitrogen metabolism nitrogen regulation protein NR(I) (TIGR01818; HMM-score: 48.4)
  Signal transduction Regulatory functions DNA interactions nitrogen regulation protein NR(I) (TIGR01818; HMM-score: 48.4)
  Signal transduction Signal transduction Two-component systems nitrogen regulation protein NR(I) (TIGR01818; HMM-score: 48.4)
  Signal transduction Signal transduction Two-component systems TMAO reductase sytem sensor TorS (TIGR02956; EC 2.7.13.3; HMM-score: 27.9)
  Signal transduction Regulatory functions DNA interactions PEP-CTERM-box response regulator transcription factor (TIGR02915; HMM-score: 20.3)
• TheSEED: see SPNINV200_20020
• ⊞⊞PFAM:
  CheY (CL0304) Response_reg; Response regulator receiver domain (PF00072; HMM-score: 92.4)
  and 2 more
  HTH (CL0123) Trans_reg_C; Transcriptional regulatory protein, C terminal (PF00486; HMM-score: 73.8)
  NADP_Rossmann (CL0063) DapB_N; Dihydrodipicolinate reductase, N-terminus (PF01113; HMM-score: 13.5)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• ⊞⊞PSORTb: Cytoplasmic
  • Cytoplasmic Score: 9.97
  • Cytoplasmic Membrane Score: 0
  • Cellwall Score: 0.01
  • Extracellular Score: 0.02
  • Internal Helices: 0
• ⊞⊞DeepLocPro: Cytoplasmic
  • Cytoplasmic Score: 0.9921
  • Cytoplasmic Membrane Score: 0.0057
  • Cell wall & surface Score: 0.0002
  • Extracellular Score: 0.002
• ⊞⊞SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.001493
  • TAT(Tat/SPI): 0.000106
  • LIPO(Sec/SPII): 0.000361
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: WP_001024075 NCBI
• UniProt:

⊟Protein sequence

• MNILVADDEEMIREGIAAFLTEEGYHVIMAKDGQEVLEKFQDLPIHLMVLDLMMPRKSGFEVLKEINQKHDIPVIVLSALGDETTQSQVFDLYADDHVTKPFSLVLLVKRIKALIRRYYVIEDIWRYQDVTVDFTSYKAHYKNEEIDLKPKELLVLKCLIQHKNQVLSREQILEEISKDVADLPCDRVVDVYIRTLRKKLALDCIVTVKNVGYKISL

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• regulator:

⊟Expression data

• PneumoExpress for strain D39V: SPV_2020 PneumoExpress

⊞Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊞Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications

Zhuo Ma, Jing-Ren Zhang
RR06 activates transcription of spr1996 and cbpA in Streptococcus pneumoniae.
J Bacteriol: 2007, 189(6);2497-509
[PubMed:17220227] [WorldCat.org] [DOI] (P p)Alistair J Standish, Uwe H Stroeher, James C Paton
The pneumococcal two-component signal transduction system RR/HK06 regulates CbpA and PspA by two distinct mechanisms.
J Bacteriol: 2007, 189(15);5591-600
[PubMed:17526693] [WorldCat.org] [DOI] (P p)Jason W Rosch, Beth Mann, Justin Thornton, Jack Sublett, Elaine Tuomanen
Convergence of regulatory networks on the pilus locus of Streptococcus pneumoniae.
Infect Immun: 2008, 76(7);3187-96
[PubMed:18443093] [WorldCat.org] [DOI] (I p)