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serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 13-DEC-2020

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae ATCC 700669
  • locus tag: SPN23F_RS11435 [old locus tags: SPN23F22270 SPN23F_22270 ]
  • pan locus tag?: PNEUPAN003925000
  • symbol: rr06
  • pan gene symbol?: rr06
  • synonym:
  • product: two-component system response regulator RR06

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPN23F_RS11435 [old locus tags: SPN23F22270 SPN23F_22270 ]
  • symbol: rr06
  • product: two-component system response regulator RR06
  • replicon: chromosome
  • strand: -
  • coordinates: 2174824..2175477
  • length: 654
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    ATGAACATTTTAGTTGCAGATGACGAGGAAATGATTAGAGAAGGAATTGCAGCATTTCTG
    ACAGAAGAGGGTTATCATGTCATTATGGCTAAGGATGGACAAGAGGTCTTGGAAAAATTT
    CAAGATCTCCCTATCCATCTCATGGTACTGGATTTAATGATGCCTAGGAAGAGTGGTTTT
    GAAGTGTTAAAAGAAATCAATCAAAAGCACGATATTCCTGTCATCGTCTTGAGTGCTCTG
    GGAGATGAAACTACTCAGTCACAGGTATTTGATCTCTATGCTGATGATCATGTGACAAAA
    CCTTTTTCTTTGGTACTGCTTGTCAAGCGTATTAAGGCGCTTATCAGACGTTACTACGTC
    ATAGAGGATATTTGGCGATATCAGGATGTAACAGTGGATTTTACCTCTTACAAAGCACAT
    TATAAAAATGAAGAAATTGATCTCAAACCAAAGGAATTACTGGTACTAAAGTGTTTGATT
    CAGCATAAAAATCAAGTTTTAAGTAGAGAGCAGATATTGGAAGAAATTTCAAAAGATGTA
    GCTGATTTACCTTGTGATAGGGTCGTTGATGTCTATATTCGTACTCTTCGCAAAAAATTA
    GCTTTAGATTGTATCGTGACTGTGAAAAATGTTGGGTATAAGATTAGTTTATGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    654

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPN23F_RS11435 [old locus tags: SPN23F22270 SPN23F_22270 ]
  • symbol: Rr06
  • description: two-component system response regulator RR06
  • length: 217
  • theoretical pI: 5.39129
  • theoretical MW: 25204.3
  • GRAVY: -0.0529954

⊟Function[edit | edit source]

  • TIGRFAM:
    Signal transduction Regulatory functions DNA interactions phosphate regulon transcriptional regulatory protein PhoB (TIGR02154; HMM-score: 155.7)
    Signal transduction Signal transduction Two-component systems phosphate regulon transcriptional regulatory protein PhoB (TIGR02154; HMM-score: 155.7)
    and 8 more
    Signal transduction Regulatory functions DNA interactions heavy metal response regulator (TIGR01387; HMM-score: 112.9)
    proteobacterial dedicated sortase system response regulator (TIGR03787; HMM-score: 82.4)
    Cellular processes Cellular processes Sporulation and germination sporulation transcription factor Spo0A (TIGR02875; HMM-score: 60.7)
    Metabolism Central intermediary metabolism Nitrogen metabolism nitrogen regulation protein NR(I) (TIGR01818; HMM-score: 48.4)
    Signal transduction Regulatory functions DNA interactions nitrogen regulation protein NR(I) (TIGR01818; HMM-score: 48.4)
    Signal transduction Signal transduction Two-component systems nitrogen regulation protein NR(I) (TIGR01818; HMM-score: 48.4)
    Signal transduction Signal transduction Two-component systems TMAO reductase sytem sensor TorS (TIGR02956; EC 2.7.13.3; HMM-score: 27.9)
    Signal transduction Regulatory functions DNA interactions PEP-CTERM-box response regulator transcription factor (TIGR02915; HMM-score: 20.3)
  • TheSEED: see SPN23F22270
  • PFAM:
    CheY (CL0304) Response_reg; Response regulator receiver domain (PF00072; HMM-score: 92.4)
    and 2 more
    HTH (CL0123) Trans_reg_C; Transcriptional regulatory protein, C terminal (PF00486; HMM-score: 73.8)
    NADP_Rossmann (CL0063) DapB_N; Dihydrodipicolinate reductase, N-terminus (PF01113; HMM-score: 13.5)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.001493
    • TAT(Tat/SPI): 0.000106
    • LIPO(Sec/SPII): 0.000361
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_001024075 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MNILVADDEEMIREGIAAFLTEEGYHVIMAKDGQEVLEKFQDLPIHLMVLDLMMPRKSGFEVLKEINQKHDIPVIVLSALGDETTQSQVFDLYADDHVTKPFSLVLLVKRIKALIRRYYVIEDIWRYQDVTVDFTSYKAHYKNEEIDLKPKELLVLKCLIQHKNQVLSREQILEEISKDVADLPCDRVVDVYIRTLRKKLALDCIVTVKNVGYKISL

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Zhuo Ma, Jing-Ren Zhang
RR06 activates transcription of spr1996 and cbpA in Streptococcus pneumoniae.
J Bacteriol: 2007, 189(6);2497-509
[PubMed:17220227] [WorldCat.org] [DOI] (P p)Alistair J Standish, Uwe H Stroeher, James C Paton
The pneumococcal two-component signal transduction system RR/HK06 regulates CbpA and PspA by two distinct mechanisms.
J Bacteriol: 2007, 189(15);5591-600
[PubMed:17526693] [WorldCat.org] [DOI] (P p)Jason W Rosch, Beth Mann, Justin Thornton, Jack Sublett, Elaine Tuomanen
Convergence of regulatory networks on the pilus locus of Streptococcus pneumoniae.
Infect Immun: 2008, 76(7);3187-96
[PubMed:18443093] [WorldCat.org] [DOI] (I p)

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