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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 20-DEC-2020

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae OXC141
  • locus tag: SPNOXC_RS08825 [old locus tags: SPNOXC16270 SPNOXC_16270 ]
  • pan locus tag?: PNEUPAN003348000
  • symbol: galR
  • pan gene symbol?: galR
  • synonym:
  • product: DNA-binding transcriptional regulator GalR

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPNOXC_RS08825 [old locus tags: SPNOXC16270 SPNOXC_16270 ]
  • symbol: galR
  • product: DNA-binding transcriptional regulator GalR
  • replicon: chromosome
  • strand: +
  • coordinates: 1650571..1651578
  • length: 1008
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_017592 (1650571..1651578) NCBI
  • BioCyc: SPNOXC_RS08825 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1635 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    ATGGCTACCTTAAAAGACATTGCACAGCTAGCCTCTGTCTCTATCGCGACCGTATCCCGC
    GTCCTCAATCGCGACCAGAGCCTATCTGTTACAGAAGAAACCAGACACCGTATTTTAACC
    GTTGCTGAAGAGCTGGGCTACACCAAGCACCTCAAGACAGGCGAGTCCCACAAACCCAAG
    CAAAAGATTGCCATTATCCAATGGGTCAGCGAACAAGGGGAGCTGGACGACCTCTACTAC
    TACCAGATTCGCCTAGGAATAGAAAAAAGAGCCCAAGAGTTGGACTATGATATCTTGCGC
    TATTTTAATGACCACCCTTTTACCCTAAGCGAGGAAGTGATTGGGATTCTCTGCATCGGA
    AAGTTTAGTCGAGCTCAGATTTCTGCCTTTGAAGAATACCAAAAGCCTCTTGTATTTCTA
    GACAGCGATACACTTTCCCTGGGACATACCTGTATTATCACGGATTTTTACACTGCTATG
    AAACAGGTTGTCGATTATTTCCTCAGTCAAGGAATGGACCGTATCGGGATTCTAACAGGC
    CTTGAAGAAACAACAGACCAAGAAGAAATCATTCAGGACAAGCGTCTAGAAAACTTCAAA
    AACTACAGTCAAGCGAGGGGAATCTATCATGATGAACTGGTCTTTCAAGGAAGATTTACT
    GCCCAGTCTGGCTATGACTTAATGAAGGAGGCCATTCAGAGCTTGGGAGACCAACTTCCG
    CCAGCATTTTTCGCAGCCAGCGATAGTTTAGCTATCGGTGCCCTCCGTGCCCTCCAAGAA
    GCTGGAATCAGCCTGCCAGATCGCGTCAGCCTCATTTCCTTTAACGACACTAGTCTGACC
    AAACAGGTCTATCCTCCCCTCTCTAGTATTACAGTTTATACTGAAGAAATGGGCCGAGCA
    GGTATGGATATTCTTAACAAGGAAGTCCTCCACGGTCGGAAAATCCCTAGCCTGACCATG
    CTGGGAACCAGACTGACATTAAGAGAAAGTACCCTAAATCAAGAATAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1008

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPNOXC_RS08825 [old locus tags: SPNOXC16270 SPNOXC_16270 ]
  • symbol: GalR
  • description: DNA-binding transcriptional regulator GalR
  • length: 335
  • theoretical pI: 4.84544
  • theoretical MW: 37878.8
  • GRAVY: -0.23403

⊟Function[edit | edit source]

  • ⊞TIGRFAM:
    Signal transduction Regulatory functions DNA interactions catabolite control protein A (TIGR01481; HMM-score: 117.8)
    and 2 more
    Signal transduction Regulatory functions DNA interactions D-fructose-responsive transcription factor (TIGR02417; HMM-score: 78.1)
    Signal transduction Regulatory functions DNA interactions trehalose operon repressor (TIGR02405; HMM-score: 71.1)
  • TheSEED: see SPNOXC16270
  • ⊞PFAM:
    Periplas_BP (CL0144) Peripla_BP_3; Periplasmic binding protein-like domain (PF13377; HMM-score: 104.4)
    and 4 more
    HTH (CL0123) LacI; Bacterial regulatory proteins, lacI family (PF00356; HMM-score: 60.2)
    Periplas_BP (CL0144) Peripla_BP_1; Periplasmic binding proteins and sugar binding domain of LacI family (PF00532; HMM-score: 35)
    Peripla_BP_4; Periplasmic binding protein domain (PF13407; HMM-score: 23.7)
    HTH (CL0123) HTH_Crp_2; Crp-like helix-turn-helix domain (PF13545; HMM-score: 14.2)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:
  • genes regulated by GalR, TF important in Galactose utilization: in TIGR4

⊟Localization[edit | edit source]

  • ⊞PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • ⊞SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.027804
    • TAT(Tat/SPI): 0.004294
    • LIPO(Sec/SPII): 0.004172
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000212522 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MATLKDIAQLASVSIATVSRVLNRDQSLSVTEETRHRILTVAEELGYTKHLKTGESHKPKQKIAIIQWVSEQGELDDLYYYQIRLGIEKRAQELDYDILRYFNDHPFTLSEEVIGILCIGKFSRAQISAFEEYQKPLVFLDSDTLSLGHTCIITDFYTAMKQVVDYFLSQGMDRIGILTGLEETTDQEEIIQDKRLENFKNYSQARGIYHDELVFQGRFTAQSGYDLMKEAIQSLGDQLPPAFFAASDSLAIGALRALQEAGISLPDRVSLISFNDTSLTKQVYPPLSSITVYTEEMGRAGMDILNKEVLHGRKIPSLTMLGTRLTLRESTLNQE

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊞Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊞Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Muhammad Afzal, Sulman Shafeeq, Irfan Manzoor, Oscar P Kuipers
GalR Acts as a Transcriptional Activator of galKT in the Presence of Galactose in Streptococcus pneumoniae.
J Mol Microbiol Biotechnol: 2015, 25(6);363-71
[PubMed:26544195] [WorldCat.org] [DOI] (I p)

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