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serotype 4
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serotype 19A
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HU-OH
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Hu15
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Hu17
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INV104
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INV200
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JJA
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MDRSPN001
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NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
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OXC141
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SP49
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SPN032672
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SPN034156
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SPN034183
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SPN994038
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SPN994039
serotype 3
SPNA45
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ST556
serotype 19F
TCH8431/19A
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Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 28-AUG-2013

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae TCH8431/19A
  • locus tag: HMPREF0837_10452 [new locus tag: HMPREF0837_RS02235 ]
  • pan locus tag?: PNEUPAN000828000
  • symbol: HMPREF0837_10452
  • pan gene symbol?: mutR1
  • synonym:
  • product: transcriptional activator, Rgg/GadR/MutR family domain protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: HMPREF0837_10452 [new locus tag: HMPREF0837_RS02235 ]
  • symbol: HMPREF0837_10452
  • product: transcriptional activator, Rgg/GadR/MutR family domain protein
  • replicon: chromosome
  • strand: +
  • coordinates: 410520..411407
  • length: 888
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    ATGCAAAAGCTAGGAGGTGGTCAGATGATTGAGAGAATGGAACTGGGGGAATTTTACAAG
    GAATTACGTTTGGCGAGAAAGCTTAAGCAGACAGATGTGGCTTGTGAGGGTCTAACAGCT
    TCTCAGTTGTCCAAGTTTGAACTAGGGCAGTCTATGCTGTCTGCGGATAAGTTGATTCTA
    GCTATCCAAGGTATAAATGTGACCTTTGATGAGTTTGGGCACAAGCTCAACAACTATCAA
    GAATCTCCACATATGCGAATCGGTCGAAAGGTTGTGAATCGCTTTGCCCATCAGGATATA
    GCTGCTTTAGAGCAGCTATTGGAGGAAGTCGATCAAGAACAGATGGCGCAGACCTATCGT
    CGTTTGAATGCCATCGTGATTAAAGATGCCATCCATTCACTAAATAAAAGCTACCCACTA
    GCAGAGGAGGATAGCGAGTTTTTGACCACCTATCTCTATGCTATCGAGTCTTGGACCTGG
    TTTGAACTCTATCTCTTTTGCAATACCATGCCCTTCTTGAGCAATCAAGATCTGATTTTT
    TTATCAACCTCCTTACTCGAAAAATCCAAAGAATTTAAAGAGTTAGTACACAATCGATTG
    TATATGAAGCAAGGACTCTTAAATATCTTATCAGAACTCATGGAGCGAAAACTTTTCTCC
    TACATCCCAATCTTCGAAGCCGAGTTGGAGAGGATGTTACGACCGTATGATGTTTTTGAA
    AAAGTATCGTGGCAATTTTTAAAGAAGATGAGTGTCTTTCTTCAAACAAAGGGAAGCAAT
    CAAAAAGAGATTGAACGCTTTATCCAATCTCTGCAGGTATTAGAAAATCCACAATTAACA
    TCCCTTTTTGAATTGCGTTTTCAGCAATATAAAGAACTTATAGATTAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    888

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: HMPREF0837_10452 [new locus tag: HMPREF0837_RS02235 ]
  • symbol: HMPREF0837_10452
  • description: transcriptional activator, Rgg/GadR/MutR family domain protein
  • length: 295
  • theoretical pI: 5.49677
  • theoretical MW: 34775
  • GRAVY: -0.284407

⊟Function[edit | edit source]

  • TIGRFAM:
    Signal transduction Regulatory functions DNA interactions transcriptional activator, Rgg/GadR/MutR family, C-terminal domain (TIGR01716; HMM-score: 224)
  • TheSEED  :
    • Positive transcriptional regulator, MutR family
  • ⊞PFAM:
    HTH (CL0123) HTH_3; Helix-turn-helix (PF01381; HMM-score: 25.3)
    HTH_19; Helix-turn-helix domain (PF12844; HMM-score: 24.7)
    and 3 more
    no clan defined CENP-U; CENP-A nucleosome associated complex (NAC) subunit (PF13097; HMM-score: 15.8)
    Trigger_C (CL0262) SurA_N_2; SurA N-terminal domain (PF13623; HMM-score: 15)
    no clan defined GlutR_dimer; Glutamyl-tRNAGlu reductase, dimerisation domain (PF00745; HMM-score: 14)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • ⊞PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • ⊞DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9481
    • Cytoplasmic Membrane Score: 0.0247
    • Cell wall & surface Score: 0.0014
    • Extracellular Score: 0.0258
  • ⊞SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.007441
    • TAT(Tat/SPI): 0.000478
    • LIPO(Sec/SPII): 0.000883
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: ADI68680 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MQKLGGGQMIERMELGEFYKELRLARKLKQTDVACEGLTASQLSKFELGQSMLSADKLILAIQGINVTFDEFGHKLNNYQESPHMRIGRKVVNRFAHQDIAALEQLLEEVDQEQMAQTYRRLNAIVIKDAIHSLNKSYPLAEEDSEFLTTYLYAIESWTWFELYLFCNTMPFLSNQDLIFLSTSLLEKSKEFKELVHNRLYMKQGLLNILSELMERKLFSYIPIFEAELERMLRPYDVFEKVSWQFLKKMSVFLQTKGSNQKEIERFIQSLQVLENPQLTSLFELRFQQYKELID

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊞Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊞Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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