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ATGAATGCAGATGATACAGTAACCATTTATGATGTCGCTCGTGAAGCAGGTGTTTCCATG
GCGACGGTCAGCCGTGTGGTCAATGGCAATAAAAATGTAAAAGAGAATACCCGTAAAAAA
GTGCTAGAGGTAATTGATCGTTTGGATTATCGTCCAAATGCAGTTGCGCGTGGTCTTGCA
AGTAAAAAGACAACCACTGTCGGTGTCGTGATTCCAAATATTACCAATGGTTATTTTTCG
AGTTTGGCTAAGGGGATTGATGATATTGCAGAAATGTACAAGTACAATATTGTCCTAGCT
AATAGCGATGAAGATAACGAGAAAGAAGTTTCTGTTGTCAATACCCTCTTTTCAAAGCAG
GTAGATGGCATTATCTATATGGGTTATCACTTGACAGATAAAATTCGCTCAGAATTTTCG
CGCTCACGTACTCCGATTGTTCTCGCAGGAACTGTCGATGTTGAGCACCAGTTGCCAAGT
GTCAATATTGACTATAAGCAAGCAACAATTGATGCAGTGAGTTACCTTGCTAAAGAAAAT
GAGCGTATTGCTTTCGTTAGCGGTCCGCTAGTGGATGACATCAATGGTAAGGTTCGTTTA
GTTGGCTACAAGGAAACCTTGAAAAAAGCAGGAATCACTTATAGTGAGGGTTTGGTATTT
GAATCTAAATATAGCTATGATGATGGTTACGACTTAGCAGAGCGTTTGATTTCATCAAAT
GCAACTGCAGCAGTTGTGACAGGTGATGAGTTGGCAGCAGGAGTCTTGAACGGTTTGGCT
GATAAAGGTGTTTCTGTGCCAGAAGATTTTGAAATTATTACTAGTGATGATTCACAAATC
TCACGCTTTACCCGTCCAAACTTGACAACGATTGCCCAACCTCTTTATGACCTTGGTGCT
ATTAGTATGCGTATGTTGACCAAGATTATGCATAAGGAAGAGTTGGAAGAACGTGAAGTT
CTCTTACCTCATGGTTTGACAGAACGTAGCTCAACACGAAAACGTAAATAG
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⊟Protein[edit | edit source]

⊟General[edit | edit source]

locus tag: SPNOXC_RS09630 [old locus tags: SPNOXC17590 SPNOXC_17590 ]
symbol: CcpA
description: catabolite control protein A
length: 336
theoretical pI: 5.17046
theoretical MW: 37116.8
GRAVY: -0.277083

⊟Function[edit | edit source]

⊞⊞TIGRFAM:
Signal transduction Regulatory functions DNA interactions catabolite control protein A (TIGR01481; HMM-score: 576.8)
and 8 more
Signal transduction Regulatory functions DNA interactions D-fructose-responsive transcription factor (TIGR02417; HMM-score: 141.6)
Signal transduction Regulatory functions DNA interactions trehalose operon repressor (TIGR02405; HMM-score: 93.8)
rhamnose ABC transporter, rhamnose-binding protein (TIGR02637; HMM-score: 18.1)
Genetic information processing Mobile and extrachromosomal element functions Other addiction module antidote protein, HigA family (TIGR02607; HMM-score: 14.2)
Signal transduction Regulatory functions DNA interactions addiction module antidote protein, HigA family (TIGR02607; HMM-score: 14.2)
Signal transduction Regulatory functions Protein interactions addiction module antidote protein, HigA family (TIGR02607; HMM-score: 14.2)
Genetic information processing Mobile and extrachromosomal element functions Prophage functions phage-associated protein, BcepMu gp16 family (TIGR04111; HMM-score: 14)
Signal transduction Regulatory functions DNA interactions transcriptional repressor BetI (TIGR03384; HMM-score: 12.2)
TheSEED: see SPNOXC17590
⊞⊞PFAM:
Periplas_BP (CL0144) Peripla_BP_3; Periplasmic binding protein-like domain (PF13377; HMM-score: 92.2)
Peripla_BP_1; Periplasmic binding proteins and sugar binding domain of LacI family (PF00532; HMM-score: 79.8)
HTH (CL0123) LacI; Bacterial regulatory proteins, lacI family (PF00356; HMM-score: 73.8)
and 7 more
Periplas_BP (CL0144) Peripla_BP_4; Periplasmic binding protein domain (PF13407; HMM-score: 60.8)
HTH (CL0123) HTH_26; Cro/C1-type HTH DNA-binding domain (PF13443; HMM-score: 16.6)
HTH_3; Helix-turn-helix (PF01381; HMM-score: 16.4)
HTH_31; Helix-turn-helix domain (PF13560; HMM-score: 14.1)
no clan defined DUF5886; Family of unknown function (DUF5886) (PF19233; HMM-score: 13.9)
HTH (CL0123) Trp_repressor; Trp repressor protein (PF01371; HMM-score: 12.7)
no clan defined DUF6148; Family of unknown function (DUF6148) (PF19645; HMM-score: 12.3)

⊟Structure, modifications & cofactors[edit | edit source]

domains:
modifications:
cofactors:
effectors:
genes regulated by CcpA, TF important in Global catabolite repression: in TIGR4

⊟Localization[edit | edit source]

⊞⊞
PSORTb: Cytoplasmic
- Cytoplasmic Score: 9.97
- Cytoplasmic Membrane Score: 0
- Cellwall Score: 0.01
- Extracellular Score: 0.02
- Internal Helices: 0
⊞⊞
SignalP: no predicted signal peptide
- SP(Sec/SPI): 0.012656
- TAT(Tat/SPI): 0.002715
- LIPO(Sec/SPII): 0.003638
predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

GI:
RefSeq: WP_000990608 NCBI
UniProt:

⊟Protein sequence[edit | edit source]

MNADDTVTIYDVAREAGVSMATVSRVVNGNKNVKENTRKKVLEVIDRLDYRPNAVARGLASKKTTTVGVVIPNITNGYFSSLAKGIDDIAEMYKYNIVLANSDEDNEKEVSVVNTLFSKQVDGIIYMGYHLTDKIRSEFSRSRTPIVLAGTVDVEHQLPSVNIDYKQATIDAVSYLAKENERIAFVSGPLVDDINGKVRLVGYKETLKKAGITYSEGLVFESKYSYDDGYDLAERLISSNATAAVVTGDELAAGVLNGLADKGVSVPEDFEIITSDDSQISRFTRPNLTTIAQPLYDLGAISMRMLTKIMHKEELEEREVLLPHGLTERSSTRKRK

⊟Experimental data[edit | edit source]

protein localization:
interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Regulation[edit | edit source]

data available for TIGR4

⊟Expression data[edit | edit source]

PneumoExpress for strain D39V: SPV_1797 PneumoExpress

⊞Biological Material[edit | edit source]

⊞Other Information[edit | edit source]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Ramkumar Iyer, Nitin S Baliga, Andrew Camilli
Catabolite control protein A (CcpA) contributes to virulence and regulation of sugar metabolism in Streptococcus pneumoniae.
J Bacteriol: 2005, 187(24);8340-9
[PubMed:16321938] [WorldCat.org] [DOI] (P p)Greer E Kaufman, Janet Yother
CcpA-dependent and -independent control of beta-galactosidase expression in Streptococcus pneumoniae occurs via regulation of an upstream phosphotransferase system-encoding operon.
J Bacteriol: 2007, 189(14);5183-92
[PubMed:17496092] [WorldCat.org] [DOI] (P p)

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