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From PneumoWiki
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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 30-JAN-2014

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⊟Summary[edit | edit source]

Contents

  • 1 Summary
  • 2 Genome View
  • 3 Gene
    • 3.1 General
    • 3.2 Accession numbers
    • 3.3 Phenotype
    • 3.4 DNA sequence
  • 4 Protein
    • 4.1 General
    • 4.2 Function
    • 4.3 Structure, modifications & cofactors
    • 4.4 Localization
    • 4.5 Accession numbers
    • 4.6 Protein sequence
    • 4.7 Experimental data
  • 5 Expression & Regulation
    • 5.1 Operon
    • 5.2 Regulation
    • 5.3 Expression data
  • 6 Biological Material
    • 6.1 Mutants
    • 6.2 Expression vector
    • 6.3 lacZ fusion
    • 6.4 GFP fusion
    • 6.5 two-hybrid system
    • 6.6 FLAG-tag construct
    • 6.7 Antibody
  • 7 Other Information
  • 8 Literature
    • 8.1 References
    • 8.2 Relevant publications
  • organism: Streptococcus pneumoniae R6
  • locus tag: spr1759 [new locus tag: SPR_RS08835 ]
  • pan locus tag?: PNEUPAN003557000
  • symbol: lytR
  • pan gene symbol?: lytR
  • synonym: brpA
  • product: Regulator of lytRABC operon

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: spr1759 [new locus tag: SPR_RS08835 ]
  • symbol: lytR
  • product: Regulator of lytRABC operon
  • replicon: chromosome
  • strand: -
  • coordinates: 1727640..1728656
  • length: 1017
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: AE007317 (1727640..1728656) NCBI
  • BioCyc: SPR1759 BioCyc
  • MicrobesOnline: 134642 MicrobesOnline
  • PneumoBrowse for strain D39V: SPV_1741 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    ATGGTTAAAAAAATTATTGGAATGGTGCTAGCTTTACTTTCTGTAACTGTAGTAGGAGTA
    GGTGTTTTTGCTTATACTATTTATCAACAAGGGACAGAAACCTTAGCTAAAACCTATAAA
    AAAATCGGTGAAGAAACCAAGGTTATTGAAGCGACTGAACCTCTAACCATTCTGTTAATG
    GGAGTGGACACCGGAAATGTTGAACGAACTGAAACTTGGGTCGGTAGAAGTGATAGCATG
    ATCTTGATGACAGTGAATCCTAAAACGAAAAAAACAACAATGATGAGTTTAGAGCGGGAT
    ATTCTGACGCGCATTGAATCAGGGAATGGTCAGGCTCATGAAGCGAAACTGAACTCAGCA
    TATGCAGATGGTGGAGCAGAGCTTGCTATAGAAACCATTCAAAAAATGATGAATATCCAT
    ATTGATCGCTATGTGATGGTCAATATGAGAGGGTTGCAAAAATTAGTGGATGCAGTAGGA
    GGTATTACAGTCAATAATATCCTAGGTTTCCCAATTTCTATCAGTGACCAAGAAGAATTT
    AATACCATTTCTATCGGTGTTGGGGAGCAACATATTGGGGGAGAAGAAGCCCTAGTCTAT
    GCACGAATGCGTTACCAAGATCCTGAGGGGGATTATGGTCGTCAAAAACGTCAACGTGAA
    GTTATTCAAAAAGTCATGGAAAAAGCTCTCAGTTTAAATAGCATTGGTCATTATCAAGAG
    ATTCTAAAAGCTTTGAGTGACAATATGCAGACCAATATTGATTTGTCTGCAAAAAGTATC
    CCTAACTTGCTAGGCTATAAAGATTCATTTAAAACCATTGAAACTCAGCAGTTGCAGGGT
    GAAGGAGAGATACTTCAAGGTGTTTCTTACCAGATTGTTTCGAGAGCACATATGTTGGAA
    ATGCAAAATATACTCCGACGTTCTTTGGGACAAGAAGAAGTTACTCAGCTTGAAACCAAT
    GCGGTTTTATTTGAAGATTTATTTGGCAGAGCACCTGTTGGTGATGAAGATAATTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1017

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: spr1759 [new locus tag: SPR_RS08835 ]
  • symbol: LytR
  • description: Regulator of lytRABC operon
  • length: 338
  • theoretical pI: 4.84886
  • theoretical MW: 37566.8
  • GRAVY: -0.218047

⊟Function[edit | edit source]

  • TIGRFAM:
    Signal transduction Regulatory functions Other cell envelope-related function transcriptional attenuator common domain (TIGR00350; HMM-score: 156.7)
  • TheSEED  :
    • Cell envelope-associated transcriptional attenuator LytR-CpsA-Psr, subfamily F2
    Regulation and Cell signaling Regulation and Cell signaling - no subcategory Cell envelope-associated LytR-CpsA-Psr transcriptional attenuators  Cell envelope-associated transcriptional attenuator LytR-CpsA-Psr, subfamily F2 (as in PMID19099556)
  • ⊞PFAM:
    no clan defined LytR_cpsA_psr; LytR_cpsA_psr family (PF03816; HMM-score: 162.1)
    and 3 more
    PetG; Cytochrome B6-F complex subunit 5 (PF02529; HMM-score: 17.9)
    DUF4012; Protein of unknown function (DUF4012) (PF13196; HMM-score: 16.7)
    COX14; Cytochrome oxidase c assembly (PF14880; HMM-score: 16.3)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • ⊞PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 1.05
    • Cytoplasmic Membrane Score: 8.78
    • Cellwall Score: 0.08
    • Extracellular Score: 0.09
    • Internal Helix: 1
  • ⊞DeepLocPro: Cytoplasmic Membrane
    • Cytoplasmic Score: 0.0003
    • Cytoplasmic Membrane Score: 0.8666
    • Cell wall & surface Score: 0.0052
    • Extracellular Score: 0.1279
  • ⊞SignalP: Signal peptide SP(Sec/SPI) length 24 aa
    • SP(Sec/SPI): 0.846218
    • TAT(Tat/SPI): 0.001343
    • LIPO(Sec/SPII): 0.007161
    • Cleavage Site: CS pos: 24-25. VFA-YT. Pr: 0.7296
  • predicted transmembrane helices (TMHMM): 1

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: AAL00562 NCBI
  • UniProt: Q8DNG0 UniProt

⊟Protein sequence[edit | edit source]

  • MVKKIIGMVLALLSVTVVGVGVFAYTIYQQGTETLAKTYKKIGEETKVIEATEPLTILLMGVDTGNVERTETWVGRSDSMILMTVNPKTKKTTMMSLERDILTRIESGNGQAHEAKLNSAYADGGAELAIETIQKMMNIHIDRYVMVNMRGLQKLVDAVGGITVNNILGFPISISDQEEFNTISIGVGEQHIGGEEALVYARMRYQDPEGDYGRQKRQREVIQKVMEKALSLNSIGHYQEILKALSDNMQTNIDLSAKSIPNLLGYKDSFKTIETQQLQGEGEILQGVSYQIVSRAHMLEMQNILRRSLGQEEVTQLETNAVLFEDLFGRAPVGDEDN

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

  • MicrobesOnline: lytR < spr1760 < spr1761

⊟Regulation[edit | edit source]

  • data available for D39, TIGR4

⊟Expression data[edit | edit source]

  • PneumoExpress for strain D39V: SPV_1741 PneumoExpress

⊞Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊞Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Ola Johnsborg, Leiv Sigve Håvarstein
Pneumococcal LytR, a protein from the LytR-CpsA-Psr family, is essential for normal septum formation in Streptococcus pneumoniae.
J Bacteriol: 2009, 191(18);5859-64
[PubMed:19581359] [WorldCat.org] [DOI] (I p)Weijie Ye, Jinghui Zhang, Zhaoche Shu, Yibing Yin, Xuemei Zhang, Kaifeng Wu
Pneumococcal LytR Protein Is Required for the Surface Attachment of Both Capsular Polysaccharide and Teichoic Acids: Essential for Pneumococcal Virulence.
Front Microbiol: 2018, 9;1199
[PubMed:29951042] [WorldCat.org] [DOI] (P e)

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  • This page was last edited on 20 January 2022, at 18:05.
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