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PangenomeTIGR4
serotype 4
D39serotype 2
D39Vserotype 2
Hungary19A-6serotype 19A
EF3030serotype 19F
670-6Bserotype 6B
6A-10serotype 6A
70585serotype 5
A026serotype 19F
A66serotype 3
AP200serotype 11A
ASP0581serotype 12F
ATCC 49619serotype 19F
ATCC 700669serotype 23F
BVJ1JLserotype 1
CGSP14serotype 14
G54serotype 19F
HU-OHserotype 3
Hu15serotype 19A
Hu17serotype 19A
INV104serotype 1
INV200serotype 14
JJAserotype 14
MDRSPN001serotype 19F
NCTC7466serotype 2
NU83127serotype 4
OXC141serotype 3
P1031serotype 1
R6serotype 2
SP49serotype 19A
SPN032672serotype 1
SPN034156serotype 3
SPN034183serotype 3
SPN994038serotype 3
SPN994039serotype 3
SPNA45serotype 3
ST556serotype 19F
TCH8431/19Aserotype 19A
Taiwan19F-14serotype 19F
Xen35serotype 4
gamPNI0373serotype 1
NCBI: 02-MAY-2018
⊟Summary[edit | edit source]
- organism: Streptococcus pneumoniae D39
- locus tag: SPD_1741 [new locus tag: SPD_RS09275 ]
- pan locus tag?: PNEUPAN003519000
- symbol: SPD_1741
- pan gene symbol?: lytR
- synonym:
- product: transcriptional regulator, putative
⊟Genome View[edit | edit source]
⊟Gene[edit | edit source]
⊟General[edit | edit source]
- type: CDS
- locus tag: SPD_1741 [new locus tag: SPD_RS09275 ]
- symbol: SPD_1741
- product: transcriptional regulator, putative
- replicon: chromosome
- strand: -
- coordinates: 1735173..1736189
- length: 1017
- essential: unknown
⊟Accession numbers[edit | edit source]
- Location: CP000410 (1735173..1736189) NCBI
- BioCyc: see SPD_RS09275
- MicrobesOnline: 2018593 MicrobesOnline
- PneumoBrowse for strain D39V: SPV_1741 PneumoBrowse
⊟Phenotype[edit | edit source]
Share your knowledge and add information here. [edit]
⊟DNA sequence[edit | edit source]
- 1
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961ATGGTTAAAAAAATTATTGGAATGGTGCTAGCTTTACTTTCTGTAACTGTAGTAGGAGTA
GGTGTTTTTGCTTATACTATTTATCAACAAGGGACAGAAACCTTAGCTAAAACCTATAAA
AAAATCGGTGAAGAAACCAAGGTTATTGAAGCGACTGAACCTCTAACCATTCTGTTAATG
GGAGTGGACACCGGAAATGTTGAACGAACTGAAACTTGGGTCGGTAGAAGTGATAGCATG
ATCTTGATGACAGTGAATCCTAAAACGAAAAAAACAACAATGATGAGTTTAGAGCGGGAT
ATTCTGACGCGCATTGAATCAGGGAATGGTCAGGCTCATGAAGCGAAACTGAACTCAGCA
TATGCAGATGGTGGAGCAGAGCTTGCTATAGAAACCATTCAAAAAATGATGAATATCCAT
ATTGATCGCTATGTGATGGTCAATATGAGAGGGTTGCAAAAATTAGTGGATGCAGTAGGA
GGTATTACAGTCAATAATATCCTAGGTTTCCCAATTTCTATCAGTGACCAAGAAGAATTT
AATACCATTTCTATCGGTGTTGGGGAGCAACATATTGGGGGAGAAGAAGCCCTAGTCTAT
GCACGAATGCGTTACCAAGATCCTGAGGGGGATTATGGTCGTCAAAAACGTCAACGTGAA
GTTATTCAAAAAGTCATGGAAAAAGCTCTCAGTTTAAATAGCATTGGTCATTATCAAGAG
ATTCTAAAAGCTTTGAGTGACAATATGCAGACCAATATTGATTTGTCTGCAAAAAGTATC
CCTAACTTGCTAGGCTATAAAGATTCATTTAAAACCATTGAAACTCAGCAGTTGCAGGGT
GAAGGAGAGATACTTCAAGGTGTTTCTTACCAGATTGTTTCGAGAGCACATATGTTGGAA
ATGCAAAATATACTCCGACGTTCTTTGGGACAAGAAGAAGTTACTCAGCTTGAAACCAAT
GCGGTTTTATTTGAAGATTTATTTGGCAGAGCACCTGTTGGTGATGAAGATAATTAA60
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⊟Protein[edit | edit source]
⊟General[edit | edit source]
- locus tag: SPD_1741 [new locus tag: SPD_RS09275 ]
- symbol: SPD_1741
- description: transcriptional regulator, putative
- length: 338
- theoretical pI: 4.84886
- theoretical MW: 37566.8
- GRAVY: -0.218047
⊟Function[edit | edit source]
- TIGRFAM: Regulatory functions Other cell envelope-related function transcriptional attenuator common domain (TIGR00350; HMM-score: 156.7)
- TheSEED :
- Cell envelope-associated transcriptional attenuator LytR-CpsA-Psr, subfamily F2
- PFAM: no clan defined LytR_cpsA_psr; LytR_cpsA_psr family (PF03816; HMM-score: 162.1)and 3 morePetG; Cytochrome B6-F complex subunit 5 (PF02529; HMM-score: 17.9)DUF4012; Protein of unknown function (DUF4012) (PF13196; HMM-score: 16.7)COX14; Cytochrome oxidase c assembly (PF14880; HMM-score: 16.3)
⊟Structure, modifications & cofactors[edit | edit source]
- domains:
- modifications:
- cofactors:
- effectors:
⊟Localization[edit | edit source]
- PSORTb: Cytoplasmic Membrane
- Cytoplasmic Score: 1.05
- Cytoplasmic Membrane Score: 8.78
- Cellwall Score: 0.08
- Extracellular Score: 0.09
- Internal Helix: 1
- SignalP: Signal peptide SP(Sec/SPI) length 24 aa
- SP(Sec/SPI): 0.846218
- TAT(Tat/SPI): 0.001343
- LIPO(Sec/SPII): 0.007161
- Cleavage Site: CS pos: 24-25. VFA-YT. Pr: 0.7296
- predicted transmembrane helices (TMHMM): 1
⊟Accession numbers[edit | edit source]
⊟Protein sequence[edit | edit source]
- MVKKIIGMVLALLSVTVVGVGVFAYTIYQQGTETLAKTYKKIGEETKVIEATEPLTILLMGVDTGNVERTETWVGRSDSMILMTVNPKTKKTTMMSLERDILTRIESGNGQAHEAKLNSAYADGGAELAIETIQKMMNIHIDRYVMVNMRGLQKLVDAVGGITVNNILGFPISISDQEEFNTISIGVGEQHIGGEEALVYARMRYQDPEGDYGRQKRQREVIQKVMEKALSLNSIGHYQEILKALSDNMQTNIDLSAKSIPNLLGYKDSFKTIETQQLQGEGEILQGVSYQIVSRAHMLEMQNILRRSLGQEEVTQLETNAVLFEDLFGRAPVGDEDN
⊟Experimental data[edit | edit source]
- protein localization:
- interaction partners:
⊟Expression & Regulation[edit | edit source]
⊟Operon[edit | edit source]
⊟Regulation[edit | edit source]
⊟Expression data[edit | edit source]
- PneumoExpress for strain D39V: SPV_1741 PneumoExpress
⊟Biological Material[edit | edit source]
⊟Mutants[edit | edit source]
⊟Expression vector[edit | edit source]
⊟lacZ fusion[edit | edit source]
⊟GFP fusion[edit | edit source]
⊟two-hybrid system[edit | edit source]
⊟FLAG-tag construct[edit | edit source]
⊟Antibody[edit | edit source]
⊟Other Information[edit | edit source]
You are kindly invited to share additional interesting facts.
⊟Literature[edit | edit source]
⊟References[edit | edit source]
- ↑ Jelle Slager, Rieza Aprianto, Jan-Willem Veening
Refining the Pneumococcal Competence Regulon by RNA Sequencing.
J Bacteriol: 2019, 201(13);
[PubMed:30885934] [WorldCat.org] [DOI] (I e)
⊟Relevant publications[edit | edit source]
Ola Johnsborg, Leiv Sigve Håvarstein
Pneumococcal LytR, a protein from the LytR-CpsA-Psr family, is essential for normal septum formation in Streptococcus pneumoniae.
J Bacteriol: 2009, 191(18);5859-64
[PubMed:19581359] [WorldCat.org] [DOI] (I p)Weijie Ye, Jinghui Zhang, Zhaoche Shu, Yibing Yin, Xuemei Zhang, Kaifeng Wu
Pneumococcal LytR Protein Is Required for the Surface Attachment of Both Capsular Polysaccharide and Teichoic Acids: Essential for Pneumococcal Virulence.
Front Microbiol: 2018, 9;1199
[PubMed:29951042] [WorldCat.org] [DOI] (P e)