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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 02-MAY-2018

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae D39
  • locus tag: SPD_1740 [new locus tag: SPD_RS09270 ]
  • pan locus tag?: PNEUPAN003520000
  • symbol: cinA
  • pan gene symbol?: cinA
  • synonym:
  • product: competence-damage protein (Exported protein 10), putative

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPD_1740 [new locus tag: SPD_RS09270 ]
  • symbol: cinA
  • product: competence-damage protein (Exported protein 10), putative
  • replicon: chromosome
  • strand: -
  • coordinates: 1733832..1735088
  • length: 1257
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    ATGAAAGCAGAAATCATTGCTGTTGGAACAGAGATTTTGACAGGACAGATTGTCAACACC
    AATGCCCAGTTTTTGTCGGAAAAACTAGCTGAGATTGGGGTAGATGTATATTTTCAGACG
    GCTGTAGGAGACAATGAAGTTCGTCTCTTGTCTTTGCTTGAGATTGCCAGTCAACGTAGC
    AGTCTGGTGATTTTGACAGGCGGTTTGGGGGCAACTGAGGACGACCTAACCAAACAAACC
    CTAGCTAAATTTTTAGGGAAAGCATTAGTCTTTGATCCTCAGGCTCAGGAGAAGTTGGAT
    ATCTTTTTTGCCCTGCGACCAGACTATGCCCGAACACCGAATAACGAAAGACAAGTTCAA
    ATTGTAGAAGGAGCGATTCCACTGCCAAACGAAACAGGACTGGCTGTTGGAGGAAAATTA
    GAAGTAGACGGAGTGACCTATGTCGTCCTTCCAGGTCCGCCAAGTGAATTGAAACCCATG
    GTCTTAAACCAACTTCTACCCAAGTTGATGACAGGGAGCAAGCTGTATTCCCGAGTTCTT
    CGTTTCTTTGGGATTGGCGAGAGCCAGTTGGTTACGATTTTGGCTGATTTAATTGATAAT
    CAGATCGATCCTACCTTGGCCCCTTATGCCAAGACAGGAGAAGTCACTCTACGTCTGTCA
    ACAAAGGCTAGCAGTCAAGAAGAGGCGAATCAAGCGCTGGATATCTTGGAAAATCAAATC
    TTGGACTGCCAGACTTTCGAAGGAATTTCTTTACGAGACTTTTGCTATGGTTATGGGGAA
    GAAACTAGTTTAGCCAGCATTGTGGTAGAAGAACTGAAAAGGCAAGGGAAAACCATCGCG
    GCTGCAGAGAGTTTGACGGCAGGTCTTTTCCAAGCTACCGTGGCGAATTTTTCTGGAGTT
    TCAAGTATATTTGAGGGTGGTTTTGTGACCTATAGCTTGGAGGAAAAATCAAGGATGTTG
    GATATTCCTGCCAAGAATTTGGAAGAACATGGTGTGGTGTCTGAATTTACAGCTCAGAAG
    ATGGCTGAGCAGGCACGAAGCAAGACCCAGTCTGATTTTGGAATTAGTTTGACTGGAGTG
    GCAGGACCAGATAGCCTAGAAGGACACCCAGTTGGGACAGTCTTCATAGGCTTGGCGCAA
    GATCAAGGAACTGAGGTTATCAAGGTTAATATTGGAGGCAGAAGCCGAGCAGATGTACGT
    CACATTGCGGTTATGCATGCCTTTAACCTAGTTCGCAAGGCTTTATTAAGTGACTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1257

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPD_1740 [new locus tag: SPD_RS09270 ]
  • symbol: CinA
  • description: competence-damage protein (Exported protein 10), putative
  • length: 418
  • theoretical pI: 4.52106
  • theoretical MW: 45064.1
  • GRAVY: 0.0349282

⊟Function[edit | edit source]

  • TIGRFAM:
    Genetic information processing DNA metabolism DNA replication, recombination, and repair competence/damage-inducible protein CinA N-terminal domain (TIGR00200; HMM-score: 364.8)
    and 3 more
    Genetic information processing DNA metabolism DNA replication, recombination, and repair amidohydrolase, PncC family (TIGR00199; EC 3.5.-.-; HMM-score: 121.2)
    molybdenum cofactor synthesis domain (TIGR00177; HMM-score: 83.9)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Molybdopterin molybdenum cofactor biosynthesis protein B (TIGR02667; HMM-score: 16.7)
  • TheSEED  :
    • C-terminal domain of CinA type S
    • Molybdopterin binding motif, CinA N-terminal domain
    Cofactors, Vitamins, Prosthetic Groups, Pigments NAD and NADP NAD and NADP cofactor biosynthesis global  C-terminal domain of CinA type S
  • PFAM:
    no clan defined CinA; Competence-damaged protein (PF02464; HMM-score: 174)
    and 2 more
    MoCF_biosynth; Probable molybdopterin binding domain (PF00994; HMM-score: 103.6)
    CinA_KH; Damage-inducible protein CinA KH domain (PF18146; HMM-score: 71.4)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.014296
    • TAT(Tat/SPI): 0.000193
    • LIPO(Sec/SPII): 0.001482
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MKAEIIAVGTEILTGQIVNTNAQFLSEKLAEIGVDVYFQTAVGDNEVRLLSLLEIASQRSSLVILTGGLGATEDDLTKQTLAKFLGKALVFDPQAQEKLDIFFALRPDYARTPNNERQVQIVEGAIPLPNETGLAVGGKLEVDGVTYVVLPGPPSELKPMVLNQLLPKLMTGSKLYSRVLRFFGIGESQLVTILADLIDNQIDPTLAPYAKTGEVTLRLSTKASSQEEANQALDILENQILDCQTFEGISLRDFCYGYGEETSLASIVVEELKRQGKTIAAAESLTAGLFQATVANFSGVSSIFEGGFVTYSLEEKSRMLDIPAKNLEEHGVVSEFTAQKMAEQARSKTQSDFGISLTGVAGPDSLEGHPVGTVFIGLAQDQGTEVIKVNIGGRSRADVRHIAVMHAFNLVRKALLSD

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulators: ComE (activation) regulon, ComX1 regulon
    ComE(response regulator)activating expression of early competence genes [1]
    ComX1(sigma factor)controls the expression of late competence genes [1]   other strains

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

  1. ↑ 1.0 1.1 Jelle Slager, Rieza Aprianto, Jan-Willem Veening
    Refining the Pneumococcal Competence Regulon by RNA Sequencing.
    J Bacteriol: 2019, 201(13);
    [PubMed:30885934] [WorldCat.org] [DOI] (I e)

⊟Relevant publications[edit | edit source]

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