PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 25-AUG-2021

⊟Summary

• organism: Streptococcus pneumoniae Hu17
• locus tag: SPNHU17_RS09265 [old locus tag: SPNHU17_01982 ]
• pan locus tag^?: PNEUPAN003520000
• symbol: SPNHU17_RS09265
• pan gene symbol^?: cinA
• synonym:
• product: competence/damage-inducible protein A

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SPNHU17_RS09265 [old locus tag: SPNHU17_01982 ]
• symbol: SPNHU17_RS09265
• product: competence/damage-inducible protein A
• replicon: chromosome
• strand: -
• coordinates: 1840936..1842192
• length: 1257
• essential: unknown

⊟Accession numbers

• Location: NZ_CP020549 (1840936..1842192) NCBI
• BioCyc: SPNHU17_RS09265 BioCyc
• MicrobesOnline:
• PneumoBrowse for strain D39V: SPV_1740 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  541
  601
  661
  721
  781
  841
  901
  961
  1021
  1081
  1141
  1201
  
  ATGAAAGCAGAAATCATTGCTGTTGGAACAGAGATTTTGACAGGACAGATTGTCAACACC
  AATGCCCAGTTTTTGTCGGAAAAACTAGCTGAGATTGGGGTAGATGTATATTTTCAGACG
  GCTGTAGGAGACAATGAAGTTCGTCTCTTGTCTTTGCTTGAGATTGCCAGTCAACGTAGC
  AGTCTGGTGATTTTGACAGGCGGTTTGGGGCCAACTGAGGACGACCTAACCAAACAAACC
  CTAGCTAAATTTTTAGGGAAAGCATTAGTCTTTGATCCTCAGGCTCAGGAGAAGTTGGAT
  ATCTTTTTTGCCCTGCGACCAGACTATGCCCGAACACCGAATAACGAAAGACAAGCTCAA
  ATTGTAGAAGGAGCGATTCCACTGCCAAACGAAACAGGACTGGCTGTTGGAGGAAAATTA
  GAAGTAGACGGAGTGACCTATGTCGTCCTTCCAGGTCCGCCAAGTGAATTGAAACCCATG
  GTCTTAAACCAACTTCTACCCAAGTTGATGACAGGGAACAAGCTGTATTCCCGAGTTCTT
  CGTTTCTTTGGGATTGGCGAGAGCCAGTTGGTTACGATTTTGGCTGATTTAATTGATAAT
  CAGATCGATCCTACCTTGGCCCCTTATGCCAAGACAGGAGAAGTCACTCTACGTCTGTCA
  ACAAAGGCTAGCAGTCAAGAAGAGGCGAATCAAGCGCTGGATATCTTGGAAAATCAAATC
  TTGGACTGCCAGACTTTCGAAGGAATTTCTTTACGAGACTTTTGCTATGGTTATGGGGAA
  GAAACTAGTTTAGCCAGCATTGTGGTAGAAGAACTGAAAAGGCAAGGGAAAACCATCGCG
  GCTGCAGAGAGTTTGACGGCAGGTCTTTTCCAAGCTACCGTGGCGAATTTTTCTGGAGTT
  TCAAGTATATTTGAGGGTGGTTTTGTGACCTATAGCTTGGAGGAAAAATCAAGGATGTTG
  GATATTCCTGCCAAGAATTTGGAAGAACATGGTGTGGTGTCTGAATTTACAGCTCAGAAG
  ATGGCTGAGCAGGCACGAAGCAAGACCCAGTCTGATTTTGGAATTAGTTTGACTGGAGTG
  GCAGGACCAGATAGCCTAGAAGGACACCCAGTTGGGACAGTCTTCATAGGCTTGGCGCAA
  GATCAAGGAACTGAGGTTATCAAGGTTAATATTGGAGGCAGAAGCCGAGCAGATGTACGT
  CACATTGCGGTTATGCATGCCTTTAACCTAGTTCGCAAGGCTTTATTAAGTGACTAA
  60
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  420
  480
  540
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  840
  900
  960
  1020
  1080
  1140
  1200
  1257
  

⊟Protein

⊟General

• locus tag: SPNHU17_RS09265 [old locus tag: SPNHU17_01982 ]
• symbol: SPNHU17_RS09265
• description: competence/damage-inducible protein A
• length: 418
• theoretical pI: 4.52106
• theoretical MW: 45089.1
• GRAVY: 0.0145933

⊟Function

• TIGRFAM:
  Genetic information processing DNA metabolism DNA replication, recombination, and repair competence/damage-inducible protein CinA N-terminal domain (TIGR00200; HMM-score: 373.3)
  and 3 more
  Genetic information processing DNA metabolism DNA replication, recombination, and repair amidohydrolase, PncC family (TIGR00199; EC 3.5.-.-; HMM-score: 121.2)
  molybdenum cofactor synthesis domain (TIGR00177; HMM-score: 84.5)
  Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Molybdopterin molybdenum cofactor biosynthesis protein B (TIGR02667; HMM-score: 15.3)
• TheSEED: data available for D39, Hungary19A-6, TIGR4
• PFAM:
  no clan defined CinA; Competence-damaged protein (PF02464; HMM-score: 174)
  and 2 more
  MoCF_biosynth; Probable molybdopterin binding domain (PF00994; HMM-score: 105.4)
  CinA_KH; Damage-inducible protein CinA KH domain (PF18146; HMM-score: 71.4)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: Cytoplasmic Membrane
  • Cytoplasmic Score: 1.78
  • Cytoplasmic Membrane Score: 8.16
  • Cellwall Score: 0.06
  • Extracellular Score: 0.01
  • Internal Helices: 0
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.014296
  • TAT(Tat/SPI): 0.000193
  • LIPO(Sec/SPII): 0.001482
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: WP_000642704 NCBI
• UniProt:

⊟Protein sequence

• MKAEIIAVGTEILTGQIVNTNAQFLSEKLAEIGVDVYFQTAVGDNEVRLLSLLEIASQRSSLVILTGGLGPTEDDLTKQTLAKFLGKALVFDPQAQEKLDIFFALRPDYARTPNNERQAQIVEGAIPLPNETGLAVGGKLEVDGVTYVVLPGPPSELKPMVLNQLLPKLMTGNKLYSRVLRFFGIGESQLVTILADLIDNQIDPTLAPYAKTGEVTLRLSTKASSQEEANQALDILENQILDCQTFEGISLRDFCYGYGEETSLASIVVEELKRQGKTIAAAESLTAGLFQATVANFSGVSSIFEGGFVTYSLEEKSRMLDIPAKNLEEHGVVSEFTAQKMAEQARSKTQSDFGISLTGVAGPDSLEGHPVGTVFIGLAQDQGTEVIKVNIGGRSRADVRHIAVMHAFNLVRKALLSD

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• data available for D39, TIGR4

⊟Expression data

• PneumoExpress for strain D39V: SPV_1740 PneumoExpress

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications