⊟Summary[edit | edit source]

PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 17-JAN-2018

⊟Summary

• organism: Streptococcus pneumoniae AP200
locus tag: SPAP_0655 [new locus tag: SPAP_RS03240 ]
pan locus tag^?: PNEUPAN001610000
symbol: SPAP_0655
pan gene symbol^?: menH
• synonym:
• product: Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SPAP_0655 [new locus tag: SPAP_RS03240 ]
• symbol: SPAP_0655
• product: Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)
• replicon: chromosome
• strand: +
• coordinates: 631385..632002
• length: 618
• essential: unknown

⊟Accession numbers

• Location: CP002121 (631385..632002) NCBI
• BioCyc: see SPAP_RS03240
• MicrobesOnline:
• PneumoBrowse for strain D39V:

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  541
  601
  
  ATGAAACTGATATTTTTGCATGGGTTAGGGCAGTCAGCAGAGTCTTGGAAAGAAGTTCGG
  AATCTACTGACAGATTATCCTTCTGAGGCTATCGAGTTATTTCCTTCTGGAGTTAGTAAC
  TATCAACAAGCTAAGGAGCGAGTTTATCAGCACCTAGCTCAAGAGACAGAACCTTTTGTT
  TTGATTGGATTGTCCTTAGGTGCTGCCCTGGCACTAGAACTTTCCAGTTACGATTTACCA
  AATCTTCGAGCTTTGATTCTGTCAGGATGCCCGCTTAAATTAGCAGGGAATATCCTATTT
  TATCTTCAGTTGCTGATTTTTAAACTACTTCCCAAAAGAGTATTTGAAAAACAGGGAGCA
  GACAAGGCTCTTATGGTCGGAGTTTCTGAGGAGTTGAAGACACTTGATTTAACGGATATA
  GCAGGAACTTGCCCTTATCCAACCTTACTAATTTGTGGTATCAAAGATAAACCGAATCTT
  AGTTCTATGAGAAGTCTTCATAAACTAATATCAGAATCCCAATTTCAGATTATCCCAGAT
  GGCCCTCATGTCTTGAATAAGGCAAAACCAAAGGAGTTTGTAGAAAAGACCAGAAGTTTC
  CTTGAATTGCTGAAATAA
  60
  120
  180
  240
  300
  360
  420
  480
  540
  600
  618
  

⊟Protein

⊟General

• locus tag: SPAP_0655 [new locus tag: SPAP_RS03240 ]
• symbol: SPAP_0655
• description: Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)
• length: 205
• theoretical pI: 8.06048
• theoretical MW: 22880.7
• GRAVY: 0.0585366

⊟Function

• ⊞⊞TIGRFAM:
  Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Menaquinone and ubiquinone 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase (TIGR03695; EC 4.2.99.20; HMM-score: 51.5)
  proline-specific peptidase (TIGR01250; HMM-score: 42.4)
  Metabolism Energy metabolism Other 3-oxoadipate enol-lactonase (TIGR02427; EC 3.1.1.24; HMM-score: 42.4)
  and 3 more
  Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Biotin pimelyl-[acyl-carrier protein] methyl ester esterase (TIGR01738; EC 3.1.1.85; HMM-score: 27.7)
  pyrimidine utilization protein D (TIGR03611; HMM-score: 18.6)
  Metabolism Energy metabolism Photosynthesis putative magnesium chelatase accessory protein (TIGR03056; HMM-score: 17.4)
• TheSEED  :
  • FIG01114063: hypothetical protein
• ⊞⊞PFAM:
  AB_hydrolase (CL0028) Abhydrolase_6; Alpha/beta hydrolase family (PF12697; HMM-score: 42.6)
  and 8 more
  Abhydrolase_2; Phospholipase/Carboxylesterase (PF02230; HMM-score: 23.7)
  Hydrolase_4; Serine aminopeptidase, S33 (PF12146; HMM-score: 20.6)
  Abhydrolase_11; Alpha/beta hydrolase domain (PF20408; HMM-score: 19.3)
  Abhydrolase_1; alpha/beta hydrolase fold (PF00561; HMM-score: 16.3)
  FSH1; Serine hydrolase (FSH1) (PF03959; HMM-score: 15.5)
  Thioesterase; Thioesterase domain (PF00975; HMM-score: 15.3)
  Lipase_3; Lipase (class 3) (PF01764; HMM-score: 12.4)
  UPF0227; Uncharacterised protein family (UPF0227) (PF05728; HMM-score: 12.2)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• ⊞⊞PSORTb: Cytoplasmic Membrane
  • Cytoplasmic Score: 1.78
  • Cytoplasmic Membrane Score: 8.16
  • Cellwall Score: 0.06
  • Extracellular Score: 0.01
  • Internal Helices: 0
• ⊞⊞SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.025111
  • TAT(Tat/SPI): 0.00018
  • LIPO(Sec/SPII): 0.003904
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: ADM84248 NCBI
• UniProt:

⊟Protein sequence

• MKLIFLHGLGQSAESWKEVRNLLTDYPSEAIELFPSGVSNYQQAKERVYQHLAQETEPFVLIGLSLGAALALELSSYDLPNLRALILSGCPLKLAGNILFYLQLLIFKLLPKRVFEKQGADKALMVGVSEELKTLDLTDIAGTCPYPTLLICGIKDKPNLSSMRSLHKLISESQFQIIPDGPHVLNKAKPKEFVEKTRSFLELLK

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• regulator:

⊟Expression data

• PneumoExpress for strain D39V:

⊞Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊞Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications