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From PneumoWiki
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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 28-AUG-2013

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae TCH8431/19A
  • locus tag: HMPREF0837_11030 [new locus tag: HMPREF0837_RS04955 ]
  • pan locus tag?: PNEUPAN001688000
  • symbol: clpP
  • pan gene symbol?: clpP
  • synonym:
  • product: endopeptidase Clp

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: HMPREF0837_11030 [new locus tag: HMPREF0837_RS04955 ]
  • symbol: clpP
  • product: endopeptidase Clp
  • replicon: chromosome
  • strand: +
  • coordinates: 947538..948128
  • length: 591
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    ATGATTCCTGTAGTTATTGAACAAACAAGCCGTGGAGAACGTTCTTACGATATTTACTCA
    CGTCTTCTCAAAGACCGCATCATTATGCTGACAGGTCCGGTTGAAGACAATATGGCTAAC
    TCTGTTATTGCCCAATTGCTTTTCTTGGATGCCCAAGATAGTACAAAAGATATTTACCTT
    TATGTCAATACACCAGGTGGTTCTGTTTCAGCTGGTTTGGCAATCGTAGATACCATGAAC
    TTTATCAAGGCAGATGTCCAAACCATTGTTATGGGAATGGCTGCATCTATGGGGACTGTC
    ATCGCATCAAGTGGGGCAAAAGGCAAACGTTTCATGCTTCCAAATGCTGAATACATGATT
    CACCAACCAATGGGCGGTACAGGTGGTGGTACCCAACAAACTGATATGGCTATCGCTGCA
    GAACACTTGCTCAAAACTCGTAATACCTTGGAAAAAATCTTGGCTGAAAATTCAGGTCAG
    TCAATGGAAAAAGTCCATGCAGATGCAGAACGTGATAACTGGATGAGCGCCCAGGAAACA
    CTTGAATATGGCTTTATTGATGAAATTATGGCCAACAATTCATTGAACTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    591

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: HMPREF0837_11030 [new locus tag: HMPREF0837_RS04955 ]
  • symbol: ClpP
  • description: endopeptidase Clp
  • length: 196
  • theoretical pI: 4.49116
  • theoretical MW: 21358.3
  • GRAVY: -0.114796

⊟Function[edit | edit source]

  • ⊞⊞reaction:
    EC 3.4.21.92?  ExPASy
    Endopeptidase Clp Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs)
  • ⊞⊞TIGRFAM:
    Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides ATP-dependent Clp endopeptidase, proteolytic subunit ClpP (TIGR00493; EC 3.4.21.92; HMM-score: 285.8)
    and 2 more
    Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides signal peptide peptidase SppA, 36K type (TIGR00706; EC 3.4.-.-; HMM-score: 22.9)
    Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides signal peptide peptidase SppA, 67K type (TIGR00705; EC 3.4.-.-; HMM-score: 21.5)
  • ⊞⊞TheSEED  :
    • ATP-dependent Clp protease proteolytic subunit ClpP (EC 3.4.21.92)
    Protein Metabolism Protein degradation Proteolysis in bacteria, ATP-dependent  ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92)
    and 1 more
    Regulation and Cell signaling Regulation and Cell signaling - no subcategory cAMP signaling in bacteria  ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92)
  • ⊞⊞PFAM:
    ClpP_crotonase (CL0127) CLP_protease; Clp protease (PF00574; HMM-score: 265.6)
    and 1 more
    SDH_sah; Serine dehydrogenase proteinase (PF01972; HMM-score: 17.2)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • ⊞⊞PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • ⊞⊞DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.6375
    • Cytoplasmic Membrane Score: 0.2737
    • Cell wall & surface Score: 0.0006
    • Extracellular Score: 0.0882
  • ⊞⊞SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.003116
    • TAT(Tat/SPI): 0.000418
    • LIPO(Sec/SPII): 0.000546
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: ADI69258 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MIPVVIEQTSRGERSYDIYSRLLKDRIIMLTGPVEDNMANSVIAQLLFLDAQDSTKDIYLYVNTPGGSVSAGLAIVDTMNFIKADVQTIVMGMAASMGTVIASSGAKGKRFMLPNAEYMIHQPMGGTGGGTQQTDMAIAAEHLLKTRNTLEKILAENSGQSMEKVHADAERDNWMSAQETLEYGFIDEIMANNSLN

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊞Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊞Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Ju Cao, Yi Gong, ShanShan Dong, Liping Zhang, Xaiofei Lai, Xuemei Zhang, Yibing Yin
Pneumococcal ClpP modulates the maturation and activation of human dendritic cells: implications for pneumococcal infections.
J Leukoc Biol: 2013, 93(5);737-49
[PubMed:23381472] [WorldCat.org] [DOI] (I p)

Retrieved from "http://pneumowiki.med.uni-greifswald.de/index.php?title=HMPREF0837_11030&oldid=170247"
Insert paragraph

NCBI: 28-AUG-2013

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae TCH8431/19A
  • locus tag: HMPREF0837_11030 [new locus tag: HMPREF0837_RS04955 ]
  • pan locus tag?: PNEUPAN001688000
  • symbol: clpP
  • pan gene symbol?: clpP
  • synonym:
  • product: endopeptidase Clp

Insert paragraph

⊟Genome View[edit | edit source]

Insert paragraph

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: HMPREF0837_11030 [new locus tag: HMPREF0837_RS04955 ]
  • symbol: clpP
  • product: endopeptidase Clp
  • replicon: chromosome
  • strand: +
  • coordinates: 947538..948128
  • length: 591
  • essential: unknown

Insert paragraph

⊟Accession numbers[edit | edit source]

Insert paragraph

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    ATGATTCCTGTAGTTATTGAACAAACAAGCCGTGGAGAACGTTCTTACGATATTTACTCA
    CGTCTTCTCAAAGACCGCATCATTATGCTGACAGGTCCGGTTGAAGACAATATGGCTAAC
    TCTGTTATTGCCCAATTGCTTTTCTTGGATGCCCAAGATAGTACAAAAGATATTTACCTT
    TATGTCAATACACCAGGTGGTTCTGTTTCAGCTGGTTTGGCAATCGTAGATACCATGAAC
    TTTATCAAGGCAGATGTCCAAACCATTGTTATGGGAATGGCTGCATCTATGGGGACTGTC
    ATCGCATCAAGTGGGGCAAAAGGCAAACGTTTCATGCTTCCAAATGCTGAATACATGATT
    CACCAACCAATGGGCGGTACAGGTGGTGGTACCCAACAAACTGATATGGCTATCGCTGCA
    GAACACTTGCTCAAAACTCGTAATACCTTGGAAAAAATCTTGGCTGAAAATTCAGGTCAG
    TCAATGGAAAAAGTCCATGCAGATGCAGAACGTGATAACTGGATGAGCGCCCAGGAAACA
    CTTGAATATGGCTTTATTGATGAAATTATGGCCAACAATTCATTGAACTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    591

Insert paragraph

This data comes from external databases and cannot be edited.

Insert paragraph

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: HMPREF0837_11030 [new locus tag: HMPREF0837_RS04955 ]
  • symbol: ClpP
  • description: endopeptidase Clp
  • length: 196
  • theoretical pI: 4.49116
  • theoretical MW: 21358.3
  • GRAVY: -0.114796

Insert paragraph

⊟Function[edit | edit source]

  • ⊞reaction:
    EC 3.4.21.92?  ExPASy
    Endopeptidase Clp Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs)
  • ⊞TIGRFAM:
    Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides ATP-dependent Clp endopeptidase, proteolytic subunit ClpP (TIGR00493; EC 3.4.21.92; HMM-score: 285.8)
    and 2 more
    Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides signal peptide peptidase SppA, 36K type (TIGR00706; EC 3.4.-.-; HMM-score: 22.9)
    Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides signal peptide peptidase SppA, 67K type (TIGR00705; EC 3.4.-.-; HMM-score: 21.5)
  • ⊞TheSEED  :
    • ATP-dependent Clp protease proteolytic subunit ClpP (EC 3.4.21.92)
    Protein Metabolism Protein degradation Proteolysis in bacteria, ATP-dependent  ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92)
    and 1 more
    Regulation and Cell signaling Regulation and Cell signaling - no subcategory cAMP signaling in bacteria  ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92)
  • ⊞PFAM:
    ClpP_crotonase (CL0127) CLP_protease; Clp protease (PF00574; HMM-score: 265.6)
    and 1 more
    SDH_sah; Serine dehydrogenase proteinase (PF01972; HMM-score: 17.2)

Insert paragraph

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

Insert paragraph

⊟Localization[edit | edit source]

  • ⊞PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • ⊞DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.6375
    • Cytoplasmic Membrane Score: 0.2737
    • Cell wall & surface Score: 0.0006
    • Extracellular Score: 0.0882
  • ⊞SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.003116
    • TAT(Tat/SPI): 0.000418
    • LIPO(Sec/SPII): 0.000546
  • predicted transmembrane helices (TMHMM): 0

Insert paragraph

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: ADI69258 NCBI
  • UniProt:

Insert paragraph

⊟Protein sequence[edit | edit source]

  • MIPVVIEQTSRGERSYDIYSRLLKDRIIMLTGPVEDNMANSVIAQLLFLDAQDSTKDIYLYVNTPGGSVSAGLAIVDTMNFIKADVQTIVMGMAASMGTVIASSGAKGKRFMLPNAEYMIHQPMGGTGGGTQQTDMAIAAEHLLKTRNTLEKILAENSGQSMEKVHADAERDNWMSAQETLEYGFIDEIMANNSLN

Insert paragraph

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

Insert paragraph

⊟Expression & Regulation[edit | edit source]

Insert paragraph

⊟Operon[edit | edit source]

Insert paragraph

⊟Regulation[edit | edit source]

Insert paragraph

⊟Expression data[edit | edit source]

Insert paragraph

⊞Biological Material[edit | edit source]

This data comes from external databases and cannot be edited.

This data comes from external databases and cannot be edited.

This data comes from external databases and cannot be edited.

This data comes from external databases and cannot be edited.

This data comes from external databases and cannot be edited.

This data comes from external databases and cannot be edited.

This data comes from external databases and cannot be edited.

⊞Other Information[edit | edit source]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

Insert paragraph

⊟Relevant publications[edit | edit source]

Ju Cao, Yi Gong, ShanShan Dong, Liping Zhang, Xaiofei Lai, Xuemei Zhang, Yibing Yin
Pneumococcal ClpP modulates the maturation and activation of human dendritic cells: implications for pneumococcal infections.
J Leukoc Biol: 2013, 93(5);737-49
[PubMed:23381472] [WorldCat.org] [DOI] (I p)

Insert paragraph